scholarly journals Synthesis and in vitro evaluation of pH-sensitive magnetic nanocomposites as methotrexate delivery system for targeted cancer therapy

2017 ◽  
Vol 71 ◽  
pp. 132-140 ◽  
Author(s):  
Juan Wu ◽  
Aipeng Deng ◽  
Wei Jiang ◽  
Renbing Tian ◽  
Yewen Shen
2017 ◽  
Vol 12 (1) ◽  
pp. 166-187 ◽  
Author(s):  
Wenliang Fu ◽  
Mohd Hezmee Mohd Noor ◽  
Loqman Mohamad Yusof ◽  
Tengku Azmi Tengku Ibrahim ◽  
Yeap Swee Keong ◽  
...  

2014 ◽  
pp. 2183
Author(s):  
Chanvit Leelayuwat ◽  
Achara Phumyen ◽  
Siriporn Chantasorn ◽  
Amonrat Jumnainsong

2021 ◽  
Vol 28 (3) ◽  
pp. 359-359
Author(s):  
Hongfei Liu ◽  
Jie Zhu ◽  
Pengyue Bao ◽  
Yueping Ding ◽  
Jiapeng Wang ◽  
...  

The authors are regretful for submitting and approving the publication of incorrect Figure 4 in this article. Below is the corrected version along with the revised caption. The electronic version of the article has already been corrected.


2018 ◽  
Vol Volume 13 ◽  
pp. 6661-6675 ◽  
Author(s):  
Chang Hyun Kim ◽  
Cheol-Ki Sa ◽  
Min Su Goh ◽  
Eun Seok Lee ◽  
Tae Hoon Kang ◽  
...  

2018 ◽  
Vol 33 (2) ◽  
pp. 170-181 ◽  
Author(s):  
Hongying Su ◽  
Wen Zhang ◽  
Yayun Wu ◽  
Xiaodong Han ◽  
Gang Liu ◽  
...  

Stimuli-responsive hydrogels have been widely researched as carrier systems, due to their excellent biocompatibility and responsiveness to external physiologic environment factors. In this study, dextran-based nanogel with covalently conjugated doxorubicin (DOX) was developed via Schiff base formation using the inverse microemulsion technique. Since the Schiff base linkages are acid-sensitive, drug release profile of the DOX-loaded nanogel would be pH-dependent. In vitro drug release studies confirmed that DOX was released much faster under acidic condition (pH 2.0, 5.0) than that at pH 7.4. Approximately 66, 28, and 9% of drug was released in 72 h at pH 2.0, 5.0, and 7.4, respectively. Cell uptake by the human breast cancer cell (MCF-7) demonstrated that the DOX-loaded dextran nanogel could be internalized through endocytosis and distributed in endocytic compartments inside tumor cells. These results indicated that the Schiff base-containing nanogel can serve as a pH-sensitive drug delivery system. And the presence of multiple aldehyde groups on the nanogel are available for further conjugations of targeting ligands or imaging probes.


2020 ◽  
Vol Volume 15 ◽  
pp. 5217-5226 ◽  
Author(s):  
Chen Jianxian ◽  
Kalsoom Saleem ◽  
Muhammad Ijaz ◽  
Masood Ur-Rehman ◽  
Ghulam Murtaza ◽  
...  

2001 ◽  
Vol 77 (3) ◽  
pp. 323-332 ◽  
Author(s):  
Claudia Valenta ◽  
Constantia E Kast ◽  
Irene Harich ◽  
Andreas Bernkop-Schnürch

2013 ◽  
Vol 22 (12) ◽  
pp. 911-921 ◽  
Author(s):  
Pradum Pundlikrao Ige ◽  
Pravin Rajput ◽  
Chandrakantsingh Pardeshi ◽  
Rajendra Kawade ◽  
Bramhanand Swami ◽  
...  

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