Silk fibroin nanoparticles prepared by electrospray as controlled release carriers of cisplatin

2014 ◽  
Vol 44 ◽  
pp. 166-174 ◽  
Author(s):  
Jing Qu ◽  
Yu Liu ◽  
Yanni Yu ◽  
Jing Li ◽  
Jingwan Luo ◽  
...  
Keyword(s):  
Controlled Release ◽  
Silk Fibroin ◽  
Silk Fibroin Nanoparticles

scholarly journals Preparation and Characterization of Silk Fibroin Nanoparticles as a Potential Drug Delivery System for 5-Fluorouracil

2019 ◽  
Vol 9 (4) ◽  
pp. 601-608 ◽  
Author(s):  
Hamid Rahmani ◽  
Ali Fattahi ◽  
Komail Sadrjavadi ◽  
Salar Khaledian ◽  
Yalda Shokoohinia
Keyword(s):  
Electron Microscope ◽  
Controlled Release ◽  
Silk Fibroin ◽  
Delivery System ◽  
In Vitro Release ◽  
Xrd Analysis ◽  
Loading Efficiency ◽  
Silk Fibroin Nanoparticles ◽  
Ft Ir

Purpose: The aim of this study is to prepare 5-fluorouracil (5-FU) loaded silk fibroin nanoparticles(SFNPs) and to achieve a controlled release delivery system with the high loading capacity. Methods: SFNPs with 1:1, 1:3, and 1:10 ratios of 5-FU to silk fibroin were prepared. SFNPswere characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD)analysis, Scanning electron microscope (SEM), and Transmission electron microscope (TEM).Loading efficiency, in vitro release, and cell viability were studied for optimal SFNPs. Results: The ratio of 1:1 was optimal formulation with the size and polydispersity index (PDI)of 221.03 nm and 0.093 before freeze drying, and 286.7 nm and 0.154 after freeze dryingby lactose, respectively. The loading efficiency and loading content of this ratio were 52.32%and 34.35%, respectively. FT-IR and XRD analysis indicated the conformational change (fromrandom coil to β-sheet) in the structure of nanoparticles by increasing amount of the drug, whichcaused the smaller size, the higher loading efficiency, and the slower release pattern. The drugloadednanoparticles reached to the half maximal inhibitory concentration (IC50) that werecomparable with free drug on MCF7 (human breast cancer) cell line. Conclusion: This study was planned to achieve a promising controlled release drug deliverysystem for carrying 5-FU, as a potent anticancer drug. SFNPs were found proper candidates fordelivery of a hydrophilic drug such as 5-FU.

scholarly journals Silk fibroin nanoparticles enhance quercetin immunomodulatory properties in DSS-induced mouse colitis

2021 ◽  
pp. 120935
Author(s):  
Patricia Diez-Echave ◽  
Antonio Jesús Ruiz-Malagón ◽  
José Alberto Molina-Tijeras ◽  
Laura Hidalgo-García ◽  
Teresa Vezza ◽  
...  
Keyword(s):  
Silk Fibroin ◽  
Silk Fibroin Nanoparticles ◽  
Immunomodulatory Properties

scholarly journals Formulation, characterization, and cellular toxicity assessment of tamoxifen-loaded silk fibroin nanoparticles in breast cancer

Drug Delivery ◽  
2021 ◽  
Vol 28 (1) ◽  
pp. 1626-1636
Author(s):  
Afrasim Moin ◽  
Shahid Ud Din Wani ◽  
Riyaz Ali Osmani ◽  
Amr S. Abu Lila ◽  
El-Sayed Khafagy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Silk Fibroin ◽  
Toxicity Assessment ◽  
Cellular Toxicity ◽  
Silk Fibroin Nanoparticles

Targeted Delivery System Based on Gemcitabine-Loaded Silk Fibroin Nanoparticles for Lung Cancer Therapy

2017 ◽  
Vol 9 (37) ◽  
pp. 31600-31611 ◽  
Author(s):  
Fatemeh Mottaghitalab ◽  
Melika Kiani ◽  
Mehdi Farokhi ◽  
Subhas C. Kundu ◽  
Rui L. Reis ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Silk Fibroin ◽  
Delivery System ◽  
Targeted Delivery ◽  
Silk Fibroin Nanoparticles ◽  
Lung Cancer Therapy ◽  
Targeted Delivery System

Bioconjugation of Neutral Protease on Silk Fibroin Nanoparticles and Application in the Controllable Hydrolysis of Sericin

2011 ◽  
Vol 59 (18) ◽  
pp. 10298-10302 ◽  
Author(s):  
Lin Zhu ◽  
Ren-Ping Hu ◽  
Hai-Yan Wang ◽  
Yuan-Jing Wang ◽  
Yu-Qing Zhang
Keyword(s):  
Silk Fibroin ◽  
Neutral Protease ◽  
Silk Fibroin Nanoparticles ◽  
Hydrolysis Of

scholarly journals Silk fibroin nanoparticles dyeing indocyanine green for imaging-guided photo-thermal therapy of glioblastoma

Drug Delivery ◽  
2018 ◽  
Vol 25 (1) ◽  
pp. 364-375 ◽  
Author(s):  
He-Lin Xu ◽  
De-Li ZhuGe ◽  
Pian-Pian Chen ◽  
Meng-Qi Tong ◽  
Meng-Ting Lin ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Silk Fibroin ◽  
Thermal Therapy ◽  
Silk Fibroin Nanoparticles

Silk fibroin double-layer microneedles for the encapsulation and controlled release of triptorelin

2021 ◽  
pp. 121433
Author(s):  
Xiaoyan Lu ◽  
Yiying Sun ◽  
Meishan Han ◽  
Daoyuan Chen ◽  
Aiping Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Double Layer ◽  
Silk Fibroin
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