Micro- and nanostructured Al2O3 surfaces for controlled vascular endothelial and smooth muscle cell adhesion and proliferation

2012 ◽  
Vol 32 (5) ◽  
pp. 1017-1024 ◽  
Author(s):  
Cenk Aktas ◽  
Eva Dörrschuck ◽  
Cathrin Schuh ◽  
Marina Martinez Miró ◽  
Juseok Lee ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cell Adhesion ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Endothelial ◽  
Cell Adhesion And Proliferation

Inhibition of rat smooth muscle cell adhesion and proliferation by non-anticoagulant heparins

2002 ◽  
Vol 193 (3) ◽  
pp. 365-372 ◽  
Author(s):  
Monsur Kazi ◽  
Karin Lundmark ◽  
Piotr Religa ◽  
Ibrahim Gouda ◽  
Olle Larm ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cell Adhesion ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Adhesion And Proliferation

Inhibition of smooth muscle cell adhesion and proliferation on heparin-doped polypyrrole

2012 ◽  
Vol 8 (1) ◽  
pp. 194-200 ◽  
Author(s):  
E.M. Stewart ◽  
X. Liu ◽  
G.M. Clark ◽  
R.M.I. Kapsa ◽  
G.G. Wallace
Keyword(s):  
Smooth Muscle ◽  
Cell Adhesion ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Adhesion And Proliferation

An In Vitro Study of Nano-fiber Polymers for Guided Vascular Regeneration

2001 ◽  
Vol 711 ◽  
Author(s):  
Derick C. Miller ◽  
Anil Thapa ◽  
Karen M. Haberstroh ◽  
Thomas J. Webster
Keyword(s):  
Smooth Muscle ◽  
Cell Adhesion ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Surrounding Tissue ◽  
Arterial Smooth Muscle Cell ◽  
Arterial Smooth Muscle ◽  
Cell Functions ◽  
Fiber Dimensions

ABSTRACTBiomaterials that successfully integrate into surrounding tissue should match not only the tissue's mechanical properties, but also the dimensions of the associated nano-structured extra-cellular matrix (ECM) components. The goal of this research was to use these ideals to develop a synthetic, nano-structured, polymeric biomaterial that has cytocompatible and mechanical behaviors similar to that of natural vascular tissue. In a novel manner, poly-lactic acid/polyglycolic acid (PLGA) (50/50 wt.% mix) and polyurethane were separately synthesized to possess a range of fiber dimensions in the micron and nanometer regime. Preliminary results indicated that decreasing fiber diameter on both PLGA and PU enhanced arterial smooth muscle cell adhesion; specifically, arterial smooth muscle cell adhesion increased 23% when PLGA fiber dimensions decreased from 500 to 50 nm and increased 76% on nano-structured, compared to conventional structured, polyurethane. However, nano-structured PLGA decreased endothelial cell adhesion by 52%, whereas adhesion of these same cells was increased by 50% on polyurethane. For these reasons, the present in vitro study provides the first evidence that polymer fiber dimensions can be used to selectively control cell functions for vascular prosthesis.

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