Antitumor efficacy of poly(brassylic acid–pentadecandioic acid) copolymer

2007 ◽  
Vol 27 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Wen-xun Guo ◽  
Ze-jun Long ◽  
Zhi Zhang ◽  
Lixin Hu
Keyword(s):  
Antitumor Efficacy ◽  
Acid Copolymer ◽  
Brassylic Acid

Antitumor efficacy of Poly(dimer acid-dodecanedioic acid) copolymer in mice bearing Sarcoma-180 tumor

2007 ◽  
Vol 18 (8) ◽  
pp. 1515-1520
Author(s):  
Wen-xun Guo ◽  
Zongli Shi ◽  
Fan-bing Zeng ◽  
Kui Liang ◽  
Xian-hong Chen ◽  
...  
Keyword(s):  
Antitumor Efficacy ◽  
Sarcoma 180 ◽  
Dimer Acid ◽  
Acid Copolymer ◽  
Dodecanedioic Acid

Cytotoxicity, NF-κB P65 inhibition, and in vivo antitumor efficacy of sesquiterpene lactones from Piptocoma rufescens

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
Y Ren ◽  
U Muñoz Acuña ◽  
DD Lantvit ◽  
F Jiménez ◽  
R García ◽  
...  
Keyword(s):  
Sesquiterpene Lactones ◽  
Antitumor Efficacy

In Vitro and In Vivo Antitumor Efficacy of Docetaxel and Sorafenib Combination in Human Pancreatic Cancer Cells

2010 ◽  
Vol 999 (999) ◽  
pp. 1-11
Author(s):  
P. Ulivi ◽  
C. Arienti ◽  
W. Zoli ◽  
M. Scarsella ◽  
S. Carloni ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Antitumor Efficacy ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells

MTOR Inhibitor MLN0128 has Antitumor Efficacy in Cell Lines With Intrinsic and Acquired Rapamycin-Resistance.

2013 ◽  
Vol 179 (2) ◽  
pp. 313
Author(s):  
B. Hassan ◽  
A. Akcakanat ◽  
S. Takafumi ◽  
K. Evans ◽  
F. Adkins ◽  
...  
Keyword(s):  
Cell Lines ◽  
Mtor Inhibitor ◽  
Antitumor Efficacy ◽  
Rapamycin Resistance

Electrospun PLGA and PLGA/gelatin scaffolds for tubularized urethral replacement: Studies in vitro and in vivo

2021 ◽  
pp. 088532822110309
Author(s):  
Jinhua Hu ◽  
Bin Ai ◽  
Shibo Zhu ◽  
Zhen Wang ◽  
Huimin Xia ◽  
...  
Keyword(s):  
Tensile Deformation ◽  
Canine Model ◽  
Urothelial Cells ◽  
Acellular Matrix ◽  
Urethral Strictures ◽  
Acid Copolymer ◽  
Hematoxylin Eosin ◽  
Collagen Tissue

To investigate the biocompatibility of polylactic acid-glycolic acid copolymer (PLGA) and PLGA/gelatin scaffolds and their suitability for tubular urethral replacement in a canine model. PLGA and PLGA/gelatin scaffolds was constructed by electrospinning. Microstructural differences between the scaffolds was examined by Scanning electron microscopy (SEM) followed by mechanical properties testing. Biocompatibility of the material was evaluated using SEM 4, 8, 12 and 72 h after PLGA and PLGA/gelatin scaffolds co-culture with urothelial cells. And confocal analysis was also used to showed the cell adhesive and growth at 12 h. Approximately 2 cm of the anterior urethra of twelve dogs were removed and replaced with a scaffold. After the surgery for 1 month performed urethrography and for 3 month perform hematoxylin–eosin (H&E) and Masson. The results indicated that PLGA and PLGA/gelatin scaffolds had a void microfilament structure, similar to that of normal acellular matrix tissue. And the tensile strength was decreased whereas the tensile deformation and suture retention strength was increased in PLGA/gelatin scaffolds compared to that in PLGA scaffolds Urothelial cells grew well on both scaffolds. Postoperatively, animals recovered well and urinated spontaneously. However, urethrography showed varying degrees of urethral strictures in the reconstructed urethras. H&E and Masson showed that multilayer urothelial cells were formed in both the proximal and distal segments of the reconstructed urethras but without continuity. There was a small amount of smooth muscle and blood vessels under the epithelium, but regenerative urothelial cells at the midpoint of the reconstructed segment did not continue. Lots of lymphocyte infiltration was observed under the epithelium, some collagen tissue was deposited under the neo-urethral epithelium were observed. In conclusion, PLGA and PLGA/gelatin scaffolds are not suitable for tubularized urethral replacement in the canine model.

scholarly journals Design of ferrocenylseleno-dopamine derivatives to optimize the Fenton-like reaction efficiency and antitumor efficacy

RSC Advances ◽  
2021 ◽  
Vol 11 (41) ◽  
pp. 25477-25483
Author(s):  
Qianya Cheng ◽  
Tong Zhou ◽  
Qing Xia ◽  
Xiulian Lu ◽  
Heng Xu ◽  
...  
Keyword(s):  
Tertiary Amine ◽  
Antitumor Efficacy ◽  
Reaction Efficiency

The tertiary amine in F4b facilitates the Fenton-like reaction to generate toxic ˙OH which induces apoptosis through CDK-2 inactivation.

scholarly journals Enhanced antitumor efficacy of a novel oncolytic vaccinia virus encoding a fully monoclonal antibody against T-cell immunoglobulin and ITIM domain (TIGIT)

EBioMedicine ◽  
2021 ◽  
Vol 64 ◽  
pp. 103240
Author(s):  
Shuguang Zuo ◽  
Min Wei ◽  
Bohao He ◽  
Anxian Chen ◽  
Shiqun Wang ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
T Cell ◽  
Vaccinia Virus ◽  
Antitumor Efficacy
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