T1rho and T2 mapping of lumbar intervertebral disc: Correlation with degeneration and morphologic changes in different disc regions

2016 ◽  
Vol 34 (7) ◽  
pp. 932-939 ◽  
Author(s):  
Min A. Yoon ◽  
Suk-Joo Hong ◽  
Chang Ho Kang ◽  
Kyung-Sik Ahn ◽  
Baek Hyun Kim
Keyword(s):  
Intervertebral Disc ◽  
T2 Mapping ◽  
Lumbar Intervertebral Disc ◽  
Morphologic Changes

Lumbar intervertebral disc abnormalities: comparison of quantitative T2 mapping with conventional MR at 3.0 T

2010 ◽  
Vol 20 (11) ◽  
pp. 2715-2722 ◽  
Author(s):  
Siegfried Trattnig ◽  
David Stelzeneder ◽  
Sabine Goed ◽  
Michael Reissegger ◽  
Tallal C. Mamisch ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
T2 Mapping ◽  
Lumbar Intervertebral Disc ◽  
3.0 T

scholarly journals DI-5-Cuffs: Lumbar Intervertebral Disc Proteoglycan and Water Content Changes in Humans after Five Days of Dry Immersion to Simulate Microgravity

2020 ◽  
Vol 21 (11) ◽  
pp. 3748
Author(s):  
Loïc Treffel ◽  
Nastassia Navasiolava ◽  
Karen Mkhitaryan ◽  
Emmanuelle Jouan ◽  
Kathryn Zuj ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Water Content ◽  
T2 Mapping ◽  
Lumbar Region ◽  
Gravitational Unloading ◽  
Lumbar Intervertebral Disc ◽  
Dry Immersion ◽  
Disc Herniations ◽  
Proteoglycan Content ◽  
Underlying Mechanisms

Most astronauts experience back pain after spaceflight, primarily located in the lumbar region. Intervertebral disc herniations have been observed after real and simulated microgravity. Spinal deconditioning after exposure to microgravity has been described, but the underlying mechanisms are not well understood. The dry immersion (DI) model of microgravity was used with eighteen male volunteers. Half of the participants wore thigh cuffs as a potential countermeasure. The spinal changes and intervertebral disc (IVD) content changes were investigated using magnetic resonance imaging (MRI) analyses with T1-T2 mapping sequences. IVD water content was estimated by the apparent diffusion coefficient (ADC), with proteoglycan content measured using MRI T1-mapping sequences centered in the nucleus pulposus. The use of thigh cuffs had no effect on any of the spinal variables measured. There was significant spinal lengthening for all of the subjects. The ADC and IVD proteoglycan content both increased significantly with DI (7.34 ± 2.23% and 10.09 ± 1.39%, respectively; mean ± standard deviation), p < 0.05). The ADC changes suggest dynamic and rapid water diffusion inside IVDs, linked to gravitational unloading. Further investigation is needed to determine whether similar changes occur in the cervical IVDs. A better understanding of the mechanisms involved in spinal deconditioning with spaceflight would assist in the development of alternative countermeasures to prevent IVD herniation.

scholarly journals Evaluation of Lumbar Intervertebral Disc Degeneration Using T1ρ and T2 Magnetic Resonance Imaging in a Rabbit Disc Injury Model

2018 ◽  
Vol 12 (2) ◽  
pp. 317-324 ◽  
Author(s):  
Tetsuhiro Ishikawa ◽  
Atsuya Watanabe ◽  
Hiroto Kamoda ◽  
Masayuki Miyagi ◽  
Gen Inoue ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Intervertebral Disc ◽  
T2 Mapping ◽  
Quantitative Mri ◽  
Resonance Imaging ◽  
Lumbar Intervertebral Disc ◽  
T1ρ Mapping ◽  
Grade 3 ◽  
Ivd Degeneration

<sec><title>Study Design</title><p>An <italic>in vivo</italic> histologic and magnetic resonance imaging (MRI) study of lumbar intervertebral disc (IVD) degeneration was conducted.</p></sec><sec><title>Purpose</title><p>To clarify the sensitivity and efficacy of T1ρ/T2 mapping for IVD degeneration, the correlation between T1ρ/T2 mapping and degenerative grades and histological findings in the lumbar IVD were investigated.</p></sec><sec><title>Overview of Literature</title><p>The early signs of IVD degeneration are proteoglycan loss, dehydration, and collagen degradation. Recently, several quantitative MRI techniques have been developed; T2 mapping can be used to evaluate hydration and collagen fiber integrity within cartilaginous tissue, and T1ρ mapping can be used to evaluate hydration and proteoglycan content.</p></sec><sec><title>Methods</title><p>Using New Zealand White rabbits, annular punctures of the IVD were made 10 times at L2/3, 5 times at L3/4, and one time at L4/5 using an 18-gauge needle (n=6) or a 21-gauge needle (n=6). At 4 and 8 weeks post-surgery, MRI was performed including T1ρ and T2 mapping. The degree of IVD degeneration was macroscopically assessed using the Thompson grading system. All specimens were cut for hematoxylin and eosin, safranin-O, and toluidine blue staining.</p></sec><sec><title>Results</title><p>Disc degeneration became more severe as the number of punctures increased and when the larger needle was used. T1ρ and T2 values were significantly different between grade 1 and grade 3 IVDs, grade 1 and grade 4 IVDs, grade 2 and grade 3 IVDs, and grade 2 and grade 4 IVDs (<italic>p</italic>&lt;0.05). There was a significant difference between grade 1 and grade 2 IVDs only in terms of T1ρ values (<italic>p</italic>&lt;0.05).</p></sec><sec><title>Conclusions</title><p>T1ρ and T2 quantitative MRI could detect these small differences. Our results suggest that T1ρ and T2 mapping are sensitive to degenerative changes of lumbar IVDs and that T1ρ mapping can be used as a clinical tool to identify early IVD degeneration.</p></sec>

Analysis of chronic low back pain with magnetic resonance imaging T2 mapping of lumbar intervertebral disc

2015 ◽  
Vol 20 (2) ◽  
pp. 295-301 ◽  
Author(s):  
Izaya Ogon ◽  
Tsuneo Takebayashi ◽  
Hiroyuki Takashima ◽  
Katsumasa Tanimoto ◽  
Kazunori Ida ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Low Back Pain ◽  
Back Pain ◽  
Magnetic Resonance ◽  
Intervertebral Disc ◽  
Chronic Low Back Pain ◽  
T2 Mapping ◽  
Low Back ◽  
Resonance Imaging ◽  
Lumbar Intervertebral Disc

scholarly journals Accelerated T2 Mapping of the Lumbar Intervertebral Disc

2020 ◽  
Vol 55 (11) ◽  
pp. 695-701
Author(s):  
Marcus Raudner ◽  
Markus Schreiner ◽  
Tom Hilbert ◽  
Tobias Kober ◽  
Michael Weber ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
T2 Mapping ◽  
Lumbar Intervertebral Disc

scholarly journals Quantitative evaluation of lumbar intervertebral disc degeneration by axial T2* mapping

Medicine ◽  
2017 ◽  
Vol 96 (51) ◽  
pp. e9393 ◽  
Author(s):  
Leitao Huang ◽  
Yuan Liu ◽  
Yi Ding ◽  
Xia Wu ◽  
Ning Zhang ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Quantitative Evaluation ◽  
Intervertebral Disc Degeneration ◽  
T2 Mapping ◽  
Lumbar Intervertebral Disc
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