Gd complexes of diethylenetriaminepentaacetic acid conjugates of low-molecular-weight chitosan oligosaccharide as a new liver-specific MRI contrast agent

2013 ◽  
Vol 31 (4) ◽  
pp. 604-609 ◽  
Author(s):  
Yan Huang ◽  
Bennan Cao ◽  
Xiaolu Yang ◽  
Qi Zhang ◽  
Xiangjun Han ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Low Molecular Weight ◽  
Chitosan Oligosaccharide ◽  
Diethylenetriaminepentaacetic Acid ◽  
Mri Contrast ◽  
Low Molecular Weight Chitosan

scholarly journals Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain–Chitosan Nanoparticles

Polymers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1681 ◽  
Author(s):  
Janaína Artem Ataide ◽  
Eloah Favero Gérios ◽  
Letícia Caramori Cefali ◽  
Ana Rita Fernandes ◽  
Maria do Céu Teixeira ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Physicochemical Properties ◽  
Enzyme Stability ◽  
Proteolytic Enzymes ◽  
Chitosan Nanoparticles ◽  
Low Molecular Weight ◽  
Chitosan Oligosaccharide ◽  
Nanoparticle Suspension ◽  
Accelerated Stability ◽  
Low Molecular Weight Chitosan

Bromelain, a set of proteolytic enzymes potential pharmaceutical applications, was encapsulated in chitosan nanoparticles to enhance enzyme stability, and the effect of different chitosan sources was evaluated. Chitosan types (i.e., low molecular weight chitosan, chitosan oligosaccharide lactate, and chitosan from shrimp shells) produced nanoparticles with different physicochemical properties, however in all cases, particle size and zeta potential decreased, and polydispersity index increased after bromelain addition. Bromelain encapsulation was higher than 84% and 79% for protein content and enzymatic activity, respectively, with low molecular weight chitosan presenting the highest encapsulation efficiency. Nanoparticle suspension was also tested for accelerated stability and rheological behavior. For the chitosan–bromelain nanoparticles, an instability index below 0.3 was recorded and, in general, the loading of bromelain in chitosan nanoparticles decreased the cohesiveness of the final suspension.

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