Treatments of avascular osteonecrosis of the hip: Current treatments

Morphologie ◽  
2020 ◽  
Author(s):  
P. Massin
Keyword(s):  
Avascular Osteonecrosis

scholarly journals The Annexin A2/S100A10 System in Health and Disease: Emerging Paradigms

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Nadia Hedhli ◽  
Domenick J. Falcone ◽  
Bihui Huang ◽  
Gabriela Cesarman-Maus ◽  
Rosemary Kraemer ◽  
...  
Keyword(s):  
Serotonin Receptor ◽  
Human Cancer ◽  
High Titer ◽  
Critical Role ◽  
Annexin A2 ◽  
Avascular Osteonecrosis ◽  
Kinase Substrate ◽  
New Findings ◽  
Human Disorders ◽  
Associated Proteins

Since its discovery as a src kinase substrate more than three decades ago, appreciation for the physiologic functions of annexin A2 and its associated proteins has increased dramatically. With its binding partner S100A10 (p11), A2 forms a cell surface complex that regulates generation of the primary fibrinolytic protease, plasmin, and is dynamically regulated in settings of hemostasis and thrombosis. In addition, the complex is transcriptionally upregulated in hypoxia and promotes pathologic neoangiogenesis in the tissues such as the retina. Dysregulation of both A2 and p11 has been reported in examples of rodent and human cancer. Intracellularly, A2 plays a critical role in endosomal repair in postarthroplastic osteolysis, and intracellular p11 regulates serotonin receptor activity in psychiatric mood disorders. In human studies, the A2 system contributes to the coagulopathy of acute promyelocytic leukemia, and is a target of high-titer autoantibodies in patients with antiphospholipid syndrome, cerebral thrombosis, and possibly preeclampsia. Polymorphisms in the humanANXA2gene have been associated with stroke and avascular osteonecrosis of bone, two severe complications of sickle cell disease. Together, these new findings suggest that manipulation of the annexin A2/S100A10 system may offer promising new avenues for treatment of a spectrum of human disorders.

Etiology of avascular osteonecrosis of the femoral head

Morphologie ◽  
2021 ◽  
Author(s):  
P. Guggenbuhl ◽  
F. Robin ◽  
S. Cadiou ◽  
J.D. Albert
Keyword(s):  
Femoral Head ◽  
Avascular Osteonecrosis

Avascular Osteonecrosis of the Talus: Current Treatment Strategies

2021 ◽  
pp. 107110072110510
Author(s):  
Hanci Zhang ◽  
Amanda N. Fletcher ◽  
Daniel J. Scott ◽  
James Nunley
Keyword(s):  
Risk Factors ◽  
Clinical Diagnosis ◽  
Treatment Strategies ◽  
Core Decompression ◽  
Bone Grafts ◽  
Current Treatment ◽  
Optimal Treatment ◽  
Patient Specific ◽  
Avascular Osteonecrosis ◽  
Current Trends

Avascular osteonecrosis (AVN) of the talus (AVNT) is a painful and challenging clinical diagnosis. AVNT has multiple known risk factors and etiologies and presents at different stages in severity. Given these unique factors, the optimal treatment solution has yet to be determined. Both joint-preserving and joint-sacrificing procedures are available, including core decompression and arthrodeses. Recently, new salvage and replacement techniques have been described including vascularized pedicle bone grafts and total talus replacement using patient-specific prosthesis; however, evidence remains limited. This review examines the current trends AVNT treatment and the emerging data behind these novel techniques.

Osteonecrosis of the knee in a patient receiving antiretroviral therapy

2002 ◽  
Vol 13 (11) ◽  
pp. 792-794 ◽  
Author(s):  
S H Allen ◽  
A L Moore ◽  
M J Tyrer ◽  
B J Holloway ◽  
M A Johnson
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Highly Active Antiretroviral Therapy ◽  
Avascular Osteonecrosis ◽  
Antiretroviral Agents ◽  
Highly Active ◽  
The Right

A case of avascular osteonecrosis of the right knee is described in a patient with HIV infection. The patient had been receiving highly active antiretroviral therapy for two years prior to presentation. Osteonecrosis is an uncommon albeit serious complication of HIV infection and is associated with use of antiretroviral agents.

scholarly journals Study of Osteocyte Behavior by High-Resolution Intravital Imaging Following Photo-Induced Ischemia

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2874
Author(s):  
Hengfeng Yuan ◽  
Wen Jiang ◽  
Yuanxin Chen ◽  
Betty Kim
Keyword(s):  
Imaging Techniques ◽  
Avascular Osteonecrosis ◽  
Functional Changes ◽  
Cellular Processes ◽  
Non Invasive ◽  
Behavioral Dynamics ◽  
Bony Anatomy ◽  
Magnetic Resonance Imaging Mri

Ischemic injuries and local hypoxia can result in osteocytes dysfunction and play a key role in the pathogenesis of avascular osteonecrosis. Conventional imaging techniques including magnetic resonance imaging (MRI) and computed tomography (CT) can reveal structural and functional changes within bony anatomy; however, characterization of osteocyte behavioral dynamics in the setting of osteonecrosis at the single cell resolution is limited. Here, we demonstrate an optical approach to study real-time osteocyte functions in vivo. Using nicotinamide adenine dinucleotide (NADH) as a biomarker for metabolic dynamics in osteocytes, we showed that NADH level within osteocytes transiently increase significantly after local ischemia through non-invasive photo-induced thrombosis of afferent arterioles followed by a steady decline. Our study presents a non-invasive optical approach to study osteocyte behavior through the modulation of local environmental conditions. Thus it provides a powerful toolkit to study cellular processes involved in bone pathologies in vivo.

scholarly journals Avascular osteonecrosis of the premaxilla secondary to disseminated intravascular coagulation: a case report

2018 ◽  
Vol 24 (4) ◽  
pp. 173-177
Author(s):  
Alizée Mouraret ◽  
Eric Gérard ◽  
Joey Le Gall ◽  
Rémi Curien
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Oral Surgery ◽  
Disease Process ◽  
Vascular Supply ◽  
Pathological State ◽  
Avascular Osteonecrosis ◽  
Bone Necrosis ◽  
Intravascular Coagulation ◽  
Severity Of The Disease ◽  
Surgery Department

Introduction:Disseminated intravascular coagulation (DIC) is a complexe systemic disorder characterized by a widespread activation of the coagulation, that may lead to thrombosis, ischemia and finally, end-organ failure. The clinical presentation of DIC depends on the site of intravascular coagulation and the severity of the disease process. Avascular osteonecrosis is a pathological state, that can occur secondary to DIC and where a reduced vascular supply leads to ischemia and bone necrosis.Observation:A 83 years old patient was sent to the oral surgery department for tooth mobility in the premaxilla, following the diagnosis of sepsis and DIC induced acute myeloid leukemia, one month ago. The examination showed an exposed avascular bone behind the 12-11-21. A diagnosis of DIC induced osteonecrosis of the premaxilla was made. A resection surgery was then programmed.Discussion:DIC may generates thrombi that might occlude intraosseous vessels in the premaxilla, and lead to bone necrosis. The maxilla is supplied by multiple branches of external carotide artery, therefore, usually, there is a lower risk of osteonecrosis in the maxilla. Nevertheless, since 1993, 4 cases of avascular necrosis of the maxilla secondary to DIC are repported in literature.Conclusion:This kind of complication, although being rare, can be dramatic for the patient as bone and aesthetic defects. Early support and management of these complications is necessary.

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