scholarly journals Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis

2019 ◽  
Vol 75 (1) ◽  
pp. 117-130.e6 ◽  
Author(s):  
Elise Fouquerel ◽  
Ryan P. Barnes ◽  
Shikhar Uttam ◽  
Simon C. Watkins ◽  
Marcel P. Bruchez ◽  
...  
Keyword(s):  
Base Damage ◽  
Telomere Loss

scholarly journals Oxidative DNA base damage and antioxidant enzyme levels in childhood acute lymphoblastic leukemia

FEBS Letters ◽  
1997 ◽  
Vol 416 (3) ◽  
pp. 286-290 ◽  
Author(s):  
Sema Sentürker ◽  
Bensu Karahalil ◽  
Mine Inal ◽  
Hülya Yilmaz ◽  
Hamza Müslümanoglu ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Antioxidant Enzyme ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Base Damage ◽  
Dna Base

Telomere loss, not average telomere length, confers radiosensitivity to TK6-irradiated cells

2012 ◽  
Vol 740 (1-2) ◽  
pp. 13-20 ◽  
Author(s):  
F. Berardinelli ◽  
D. Nieri ◽  
A. Sgura ◽  
C. Tanzarella ◽  
A. Antoccia
Keyword(s):  
Telomere Length ◽  
Telomere Loss

scholarly journals Base damage, local sequence context andTP53mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutability

2015 ◽  
Vol 43 (19) ◽  
pp. 9133-9146 ◽  
Author(s):  
Georgina E. Menzies ◽  
Simon H. Reed ◽  
Andrea Brancale ◽  
Paul D. Lewis
Keyword(s):  
Molecular Dynamics ◽  
Sequence Context ◽  
Base Damage ◽  
Local Sequence

Free Radical-Induced Tandem Base Damage in DNA Oligomers

1997 ◽  
Vol 23 (7) ◽  
pp. 1021-1030 ◽  
Author(s):  
Harold C Box ◽  
Edwin E Budzinski ◽  
Jean B Dawidzik ◽  
Jason S Gobey ◽  
Harold G Freund
Keyword(s):  
Free Radical ◽  
Base Damage ◽  
Dna Oligomers

scholarly journals Pyrimidine base damage is increased in women with BRCA mutations

2013 ◽  
Vol 338 (2) ◽  
pp. 267-270 ◽  
Author(s):  
Edwin E. Budzinski ◽  
Helen B. Patrzyc ◽  
Jean B. Dawidzik ◽  
Harold G. Freund ◽  
Peter Frederick ◽  
...  
Keyword(s):  
Brca Mutations ◽  
Base Damage ◽  
Pyrimidine Base

DNA base damage in mammalian chromatin by hydrogen peroxide/ferric and cupric ions

1990 ◽  
Vol 9 ◽  
pp. 49 ◽  
Author(s):  
Miral Dizdaroglu ◽  
Govind Rao ◽  
Barry Halliwell ◽  
Ewa Gajewski
Keyword(s):  
Hydrogen Peroxide ◽  
Base Damage ◽  
Dna Base

Oxidative base damage to DNA: specificity of base excision repair enzymes

2000 ◽  
Vol 462 (2-3) ◽  
pp. 121-128 ◽  
Author(s):  
Jean Cadet ◽  
Anne-Gaëlle Bourdat ◽  
Cédric D'Ham ◽  
Victor Duarte ◽  
Didier Gasparutto ◽  
...  
Keyword(s):  
Base Excision Repair ◽  
Excision Repair ◽  
Base Damage ◽  
Repair Enzymes ◽  
Base Excision ◽  
Dna Specificity ◽  
Oxidative Base Damage

scholarly journals Oxidative DNA base modifications as factors in carcinogenesis.

1998 ◽  
Vol 45 (2) ◽  
pp. 561-572 ◽  
Author(s):  
R Olinski ◽  
P Jaruga ◽  
T H Zastawny
Keyword(s):  
Metastatic Potential ◽  
Base Damage ◽  
Normal Tissues ◽  
Dna Base ◽  
Dna Modifications ◽  
Cancer Initiation ◽  
Base Modifications ◽  
Therapeutic Doses ◽  
Oxidative Base Damage

Reactive oxygen species can cause extensive DNA modifications including modified bases. Some of the DNA base damage has been found to possess premutagenic properties. Therefore, if not repaired, it can contribute to carcinogenesis. We have found elevated amounts of modified bases in cancerous and precancerous tissues as compared with normal tissues. Most of the agents used in anticancer therapy are paradoxically responsible for induction of secondary malignancies and some of them may generate free radicals. The results of our experiments provide evidence that exposure of cancer patients to therapeutic doses of ionizing radiation and anticancer drugs causes base modifications in genomic DNA of lymphocytes. Some of these base damages could lead to mutagenesis in critical genes and ultimately to secondary cancers such as leukemias. This may point to an important role of oxidative base damage in cancer initiation. Alternatively, the increased level of the modified base products may contribute to genetic instability and metastatic potential of tumor cells.

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