scholarly journals The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy

2019 ◽  
Vol 73 (3) ◽  
pp. 429-445.e7 ◽  
Author(s):  
Subhash Mehto ◽  
Kautilya Kumar Jena ◽  
Parej Nath ◽  
Swati Chauhan ◽  
Srinivasa Prasad Kolapalli ◽  
...  
Keyword(s):  
Risk Factor ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Nlrp3 Inflammasome ◽  
Disease Risk ◽  
Inflammasome Activation ◽  
Disease Risk Factor ◽  
Selective Autophagy ◽  
Nlrp3 Inflammasome Activation

scholarly journals Crohn's disease: risk factor for colorectal cancer

2017 ◽  
Vol 37 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Sandra Cristina Dias dos Santos ◽  
Laura Elisabete Ribeiro Barbosa
Keyword(s):  
Colorectal Cancer ◽  
Risk Factor ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Risk ◽  
Disease Risk Factor

Tu1809 - NLRP3 Inflammasome Activation Due to a Card8 V44I Mutation Leads to Crohn's Disease Responsive to IL-B Blockade

2018 ◽  
Vol 154 (6) ◽  
pp. S-1026
Author(s):  
Liming Mao ◽  
Atsushi Kitani ◽  
Morgan Similuk ◽  
Andrew Oler ◽  
Lindsey Albenberg ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation

scholarly journals Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn’s disease

2018 ◽  
Vol 128 (5) ◽  
pp. 1793-1806 ◽  
Author(s):  
Liming Mao ◽  
Atsushi Kitani ◽  
Morgan Similuk ◽  
Andrew J. Oler ◽  
Lindsey Albenberg ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Loss Of Function ◽  
Nlrp3 Inflammasome Activation

scholarly journals Fucoidan Inhibits NLRP3 Inflammasome Activation by Enhancing p62/SQSTM1-Dependent Selective Autophagy to Alleviate Atherosclerosis

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Yufei Cheng ◽  
Xudong Pan ◽  
Jing Wang ◽  
Xu Li ◽  
Shaonan Yang ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Sulfated Polysaccharide ◽  
Inflammasome Activation ◽  
Inhibitory Effects ◽  
Selective Autophagy ◽  
Sequestosome 1 ◽  
Pyrin Domain ◽  
Nlrp3 Inflammasome Activation

NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation contributes to the progression of atherosclerosis, and autophagy inhibits inflammasome activation by targeting macrophages. We investigated whether fucoidan, a marine sulfated polysaccharide derived from brown seaweeds, could reduce NLRP3 inflammasome activation by enhancing sequestosome 1 (p62/SQSTM1)-dependent selective autophagy to alleviate atherosclerosis in high-fat-fed ApoE-/- mice with partial carotid ligation and differentiated THP-1 cells incubated with oxidized low-density lipoprotein (oxLDL). Fucoidan significantly ameliorated lipid accumulation, attenuated progression of carotid atherosclerotic plaques, deregulated the expression of NLRP3 inflammasome, autophagy receptor p62, and upregulated microtubule-associated protein light chain 3 (LC3)-II/I levels. Transmission electron microscopy and GFP-RFP-LC3 lentivirus transfection further demonstrated that fucoidan could activate autophagy. Mechanistically, fucoidan remarkably inhibited NLRP3 inflammasome activation, which was mostly dependent on autophagy. The inhibitory effects of fucoidan on NLRP3 inflammasome were enhanced by autophagy activator rapamycin (Rapa) and alleviated by autophagy inhibitor 3-methyladenine (3-MA). Fucoidan promoted the colocalization of NLRP3 and p62. Knockdown of p62 and ATG5 by small interfering RNA significantly reduced the inhibitory effects of fucoidan treatment on NLRP3 inflammasome. The data suggest that fucoidan can inhibit NLRP3 inflammasome activation by enhancing p62/SQSTM1-dependent selective autophagy to alleviate atherosclerosis.

scholarly journals IRGM restrains NLRP3 inflammasome activation by mediating its SQSTM1/p62-dependent selective autophagy

Autophagy ◽  
2019 ◽  
Vol 15 (9) ◽  
pp. 1645-1647 ◽  
Author(s):  
Subhash Mehto ◽  
Swati Chauhan ◽  
Kautilya Kumar Jena ◽  
Nishant Ranjan Chauhan ◽  
Parej Nath ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Selective Autophagy ◽  
Nlrp3 Inflammasome Activation
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