scholarly journals Telomere Loop Dynamics in Chromosome End Protection

2018 ◽  
Vol 71 (4) ◽  
pp. 510-525.e6 ◽  
Author(s):  
David Van Ly ◽  
Ronnie Ren Jie Low ◽  
Sonja Frölich ◽  
Tara K. Bartolec ◽  
Georgia R. Kafer ◽  
...  
Keyword(s):  
Loop Dynamics ◽  
Chromosome End Protection

scholarly journals Telomere-loop dynamics in chromosome end protection

2018 ◽  
Author(s):  
David Van Ly ◽  
Ronnie Ren Jie Low ◽  
Sonja Frölich ◽  
Tara K. Bartolec ◽  
Georgia R. Kafer ◽  
...  
Keyword(s):  
Super Resolution ◽  
G1 Arrest ◽  
Loop Formation ◽  
End Joining ◽  
Loop Dynamics ◽  
Non Homologous End Joining ◽  
Super Resolution Microscopy ◽  
Telomere Structure ◽  
Chromosome End Protection

SUMMARYWe used super-resolution microscopy to investigate the role of macromolecular telomere structure in chromosome end protection. In murine and human cells with reduced TRF2, we find that ATM-activation at chromosome ends occurs with a structural change from t-loops to linearized chromosome ends through t-loop unfolding. Comparably, we find Aurora B kinase regulates telomere linearity concurrent with ATM activation at telomeres during mitotic arrest. Using a separation of function allele, we find that the TRFH domain of TRF2 regulates t-loop formation while suppressing ATM activity. Notably, we demonstrate that telomere linearity and ATM activation occur separately from telomere fusion via non-homologous end-joining (NHEJ). Further, we show that linear DDR-positive telomeres can remain resistant to fusion, even during an extended G1-arrest when NHEJ is most active. Collectively, these results suggest t-loops act as conformational switches that regulate ATM activation at chromosome ends independent of mechanisms to suppress chromosome end fusion.

Automatic MTPA Tracking in IPMSM Drives: Loop Dynamics, Design, and Auto-Tuning

2017 ◽  
Vol 53 (5) ◽  
pp. 4547-4558 ◽  
Author(s):  
Nicola Bedetti ◽  
Sandro Calligaro ◽  
Christian Olsen ◽  
Roberto Petrella
Keyword(s):  
Loop Dynamics ◽  
Auto Tuning

Functional loop dynamics of the S-component of ECF transporter FolT

2018 ◽  
Vol 116 (19-20) ◽  
pp. 2613-2621
Author(s):  
Linqiong Qiu ◽  
Cong Shen ◽  
Jianing Song ◽  
Yingkai Zhang ◽  
John Z. H. Zhang
Keyword(s):  
Loop Dynamics

scholarly journals Novel neuronal and astrocytic mechanisms in thalamocortical loop dynamics

2002 ◽  
Vol 357 (1428) ◽  
pp. 1675-1693 ◽  
Author(s):  
Vincenzo Crunelli ◽  
Kate L. Blethyn ◽  
David W. Cope ◽  
Stuart W. Hughes ◽  
H. Rheinallt Parri ◽  
...  
Keyword(s):  
Low Voltage ◽  
Electrical Coupling ◽  
Low Frequency ◽  
Network Activity ◽  
Thalamic Neuron ◽  
Cellular Mechanisms ◽  
Brain Areas ◽  
Sensory Stimuli ◽  
Loop Dynamics ◽  
Intracellular Ca

In this review, we summarize three sets of findings that have recently been observed in thalamic astrocytes and neurons, and discuss their significance for thalamocortical loop dynamics. (i) A physiologically relevant ‘window’ component of the low–voltage–activated, T–type Ca 2+ current ( I Twindow ) plays an essential part in the slow (less than 1 Hz) sleep oscillation in adult thalamocortical (TC) neurons, indicating that the expression of this fundamental sleep rhythm in these neurons is not a simple reflection of cortical network activity. It is also likely that I Twindow underlies one of the cellular mechanisms enabling TC neurons to produce burst firing in response to novel sensory stimuli. (ii) Both electrophysiological and dye–injection experiments support the existence of gap junction–mediated coupling among young and adult TC neurons. This finding indicates that electrical coupling–mediated synchronization might be implicated in the high and low frequency oscillatory activities expressed by this type of thalamic neuron. (iii) Spontaneous intracellular Ca 2+ ([Ca 2+ ] i ) waves propagating among thalamic astrocytes are able to elicit large and long–lasting N –methyl–D–aspartate–mediated currents in TC neurons. The peculiar developmental profile within the first two postnatal weeks of these astrocytic [Ca 2+ ] i transients and the selective activation of these glutamate receptors point to a role for this astrocyte–to–neuron signalling mechanism in the topographic wiring of the thalamocortical loop. As some of these novel cellular and intracellular properties are not restricted to thalamic astrocytes and neurons, their significance may well apply to (patho)physiological functions of glial and neuronal elements in other brain areas.

Hydrophobic Loop Dynamics and Actin Filament Stability†

Biochemistry ◽  
2006 ◽  
Vol 45 (45) ◽  
pp. 13576-13584 ◽  
Author(s):  
Damon Scoville ◽  
John D. Stamm ◽  
Dora Toledo-Warshaviak ◽  
Christian Altenbach ◽  
Martin Phillips ◽  
...  
Keyword(s):  
Actin Filament ◽  
Loop Dynamics

scholarly journals A closed-loop dynamics analysis by Appel's method.

1986 ◽  
Vol 4 (1) ◽  
pp. 9-15
Author(s):  
Takahiro MASUDA ◽  
Akemi FUTAKAWA ◽  
Suguru ARIMOTO ◽  
Fumio MIYAZAKI
Keyword(s):  
Closed Loop ◽  
Dynamics Analysis ◽  
Loop Dynamics
Sign in / Sign up

Export Citation Format

Share Document