scholarly journals Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals

2018 ◽  
Vol 69 (1) ◽  
pp. 48-61.e6 ◽  
Author(s):  
Nilay Shah ◽  
Muhammad Ahmad Maqbool ◽  
Yousra Yahia ◽  
Amal Zine El Aabidine ◽  
Cyril Esnault ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Gene Transcription ◽  
Rna Polymerase Ii Ctd

scholarly journals Genetic analysis of the RNA polymerase II CTD in Drosophila

Methods ◽  
2019 ◽  
Vol 159-160 ◽  
pp. 129-137
Author(s):  
Feiyue Lu ◽  
David S. Gilmour
Keyword(s):  
Genetic Analysis ◽  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Rna Polymerase Ii Ctd

Key features of the interaction between Pcf11 CID and RNA polymerase II CTD

2005 ◽  
Vol 12 (2) ◽  
pp. 144-151 ◽  
Author(s):  
Christian G Noble ◽  
David Hollingworth ◽  
Stephen R Martin ◽  
Valerie Ennis-Adeniran ◽  
Stephen J Smerdon ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Key Features ◽  
Rna Polymerase Ii Ctd

scholarly journals RNA Polymerase II CTD phosphatase Rtr1 fine-tunes transcription termination

PLoS Genetics ◽  
2020 ◽  
Vol 16 (3) ◽  
pp. e1008317 ◽  
Author(s):  
Jose F. Victorino ◽  
Melanie J. Fox ◽  
Whitney R. Smith-Kinnaman ◽  
Sarah A. Peck Justice ◽  
Katlyn H. Burriss ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Transcription Termination ◽  
Ctd Phosphatase ◽  
Rna Polymerase Ii Ctd

scholarly journals Feedback regulation of vitamin D metabolism by 1,25-dihydroxycholecalciferol

1977 ◽  
Vol 164 (1) ◽  
pp. 83-89 ◽  
Author(s):  
K W Colston ◽  
I M A Evans ◽  
T C Spelsberg ◽  
I MacIntyre
Keyword(s):  
Vitamin D ◽  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Gene Transcription ◽  
Subcutaneous Administration ◽  
Feedback Regulation ◽  
Rna Polymerase I ◽  
Hydroxylase Activity ◽  
Vitamin D Metabolism ◽  
Polymerase I

Many factors influence the production of 1,25(OH)2D3 (1,25-dihydroxycholecalciferol) by the kidney. One important factor seems to be feedback regulation by 1,25(OH)2D3 itself. Administration of 1,25(OH)2D3 to vitamin D-deficient chicks abolishes renal 25(OH)D3(25-hydroxycholecalciferol)1-hydroxylase activity and induces the appearance of 25(OH)D3 24-hydroxylase activity. It is likely that these effects are mediated via a nuclear effect, as they are prevented by pretreatment with actinomycin D and alpha-amanitin. Further, 1,25(OH)2D3 has a marked effect on gene transcription in the kidney cell, as assessed by measurement of RNA polymerase activities. RNA polymerase I and II activities are 80-90% inhibited by 12.5nmol of 1,25(OH)2D3 within 30min of subcutaneous administration, indicating an immediate and massive decrease in total gene transcription. By 4h RNA polymerase II activity has returned to control values, but RNA polymerase I activity is markedly enhanced. These results are consistent with the view that regulation of cholecalciferol metabolism in the kidney is associated with an effect of the active metabolite on the kidney nucleus.

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