scholarly journals Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

2017 ◽  
Vol 68 (4) ◽  
pp. 821 ◽  
Author(s):  
Kuang Shen ◽  
Abigail Choe ◽  
David M. Sabatini
Keyword(s):  
Amino Acid ◽  
Amino Acid Availability ◽  
Rag Gtpase

scholarly journals GATOR1-dependent recruitment of FLCN–FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids

2018 ◽  
Vol 217 (8) ◽  
pp. 2765-2776 ◽  
Author(s):  
Jin Meng ◽  
Shawn M. Ferguson
Keyword(s):  
Amino Acid ◽  
Cellular Responses ◽  
Bound State ◽  
Interacting Proteins ◽  
Gtpase Activating Protein ◽  
Guanosine Diphosphate ◽  
Amino Acid Availability ◽  
Heterodimeric Complex ◽  
Rag Gtpase ◽  
The Relationship

Folliculin (FLCN) is a tumor suppressor that coordinates cellular responses to changes in amino acid availability via regulation of the Rag guanosine triphosphatases. FLCN is recruited to lysosomes during amino acid starvation, where it interacts with RagA/B as a heterodimeric complex with FLCN-interacting proteins (FNIPs). The FLCN–FNIP heterodimer also has GTPase-activating protein (GAP) activity toward RagC/D. These properties raised two important questions. First, how is amino acid availability sensed to regulate lysosomal abundance of FLCN? Second, what is the relationship between FLCN lysosome localization, RagA/B interactions, and RagC/D GAP activity? In this study, we show that RagA/B nucleotide status determines the FLCN–FNIP1 recruitment to lysosomes. Starvation-induced FLCN–FNIP lysosome localization requires GAP activity toward Rags 1 (GATOR1), the GAP that converts RagA/B to the guanosine diphosphate (GDP)-bound state. This places FLCN–FNIP recruitment to lysosomes under the control of amino acid sensors that act upstream of GATOR1. By binding to RagA/BGDP and acting on RagC/D, FLCN–FNIP can coordinate nucleotide status between Rag heterodimer subunits in response to changes in amino acid availability.

scholarly journals Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

2017 ◽  
Vol 68 (3) ◽  
pp. 552-565.e8 ◽  
Author(s):  
Kuang Shen ◽  
Abigail Choe ◽  
David M. Sabatini
Keyword(s):  
Amino Acid ◽  
Amino Acid Availability ◽  
Rag Gtpase

Combined effect of citrulline and lactoserum on amino acid availability in aged rats

Nutrition ◽  
2021 ◽  
Vol 87-88 ◽  
pp. 111196
Author(s):  
Prasanthi Jegatheesan ◽  
Christel Vicente ◽  
Perrine Marquet de Rouge ◽  
Nathalie Neveux ◽  
Radji Ramassamy ◽  
...  
Keyword(s):  
Amino Acid ◽  
Combined Effect ◽  
Aged Rats ◽  
Amino Acid Availability

Synergistic effect of citrulline and lactoserum on amino acid availability

2018 ◽  
Vol 37 ◽  
pp. S163
Author(s):  
P. Jegatheesan ◽  
C. Vicente ◽  
P. Marquet De Rouge ◽  
N. Neveux ◽  
R. Ramassamy ◽  
...  
Keyword(s):  
Amino Acid ◽  
Synergistic Effect ◽  
Amino Acid Availability

scholarly journals Amino acid availability of feed ingredients for poultry.

1986 ◽  
Vol 23 (3) ◽  
pp. 147-156 ◽  
Author(s):  
Masayoshi YAMAZAKI ◽  
Hachiro KAMATA
Keyword(s):  
Amino Acid ◽  
Feed Ingredients ◽  
Amino Acid Availability
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