Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery

Meng S. Choy; Yang Li; Luciana E.S.F. Machado; Micha B.A. Kunze; Christopher R. Connors; Xingyu Wei; Kresten Lindorff-Larsen; Rebecca Page; Wolfgang Peti

doi:10.1016/j.molcel.2017.01.014

Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery

Molecular Cell ◽

10.1016/j.molcel.2017.01.014 ◽

2017 ◽

Vol 65 (4) ◽

pp. 644-658.e5 ◽

Cited By ~ 39

Author(s):

Meng S. Choy ◽

Yang Li ◽

Luciana E.S.F. Machado ◽

Micha B.A. Kunze ◽

Christopher R. Connors ◽

...

Keyword(s):

Protein Dynamics ◽

Conformational Rigidity

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Analysis of Actin Protein Dynamics at the Protrusion Process of Cell Movement

IEEJ Transactions on Electronics Information and Systems ◽

10.1541/ieejeiss.134.177 ◽

2014 ◽

Vol 134 (2) ◽

pp. 177-182

Author(s):

Takuya Miura ◽

Michiko Sugawara ◽

Tohru Yagi ◽

Ken-ichi Tsubota ◽

Hao Liu

Keyword(s):

Protein Dynamics ◽

Cell Movement ◽

Actin Protein

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Faculty Opinions recommendation of Recombinant antibodies against subcellular fractions used to track endogenous Golgi protein dynamics in vivo.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1016772.201271 ◽

2003 ◽

Author(s):

Sachdev Sidhu

Keyword(s):

Protein Dynamics ◽

Recombinant Antibodies ◽

Subcellular Fractions ◽

Golgi Protein

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Faculty Opinions recommendation of A new spin probe of protein dynamics: nitrogen relaxation in 15N-2H amide groups.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1025385.297887 ◽

2005 ◽

Author(s):

Gottfried Otting

Keyword(s):

Protein Dynamics ◽

Spin Probe

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Faculty Opinions recommendation of Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1040833.489885 ◽

2006 ◽

Author(s):

Brent Iverson

Keyword(s):

Protein Dynamics ◽

Conformational Heterogeneity

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Faculty Opinions recommendation of Green-to-red photoconvertible fluorescent proteins: tracking cell and protein dynamics on standard wide-field mercury arc-based microscopes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.5134966.7483054 ◽

2010 ◽

Author(s):

Laura Trinkle-Mulcahy

Keyword(s):

Protein Dynamics ◽

Fluorescent Proteins ◽

Wide Field

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Faculty Opinions recommendation of Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs large.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717955669.793460673 ◽

2012 ◽

Author(s):

Yang Hong

Keyword(s):

Protein Dynamics ◽

Protein Complex ◽

Core Protein ◽

Septate Junction ◽

Discs Large ◽

Stable Core

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Faculty Opinions recommendation of Contributions of ionic interactions and protein dynamics to cytochrome P450 2D6 (CYP2D6) substrate and inhibitor binding.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725297021.793502782 ◽

2015 ◽

Author(s):

John Lowe

Keyword(s):

Cytochrome P450 ◽

Protein Dynamics ◽

Ionic Interactions ◽

Cytochrome P450 2D6 ◽

Inhibitor Binding ◽

P450 2D6

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Faculty Opinions recommendation of Protein dynamics: Conformational footprints.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726868932.793524619 ◽

2016 ◽

Author(s):

Dario Doller

Keyword(s):

Protein Dynamics

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Faculty Opinions recommendation of The role of protein dynamics in the evolution of new enzyme function.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726731594.793532405 ◽

2017 ◽

Author(s):

Qiang Cui

Keyword(s):

Protein Dynamics ◽

Enzyme Function

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Faculty Opinions recommendation of System analysis shows distinct mechanisms and common principles of nuclear envelope protein dynamics.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9899960.10614054 ◽

2011 ◽

Author(s):

Markus Engstler ◽

Manfred Alsheimer

Keyword(s):

Nuclear Envelope ◽

Protein Dynamics ◽

Envelope Protein ◽

System Analysis

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