scholarly journals Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells

2015 ◽  
Vol 59 (3) ◽  
pp. 359-371 ◽  
Author(s):  
Andreas Kuehne ◽  
Hila Emmert ◽  
Joern Soehle ◽  
Marc Winnefeld ◽  
Frank Fischer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Skin ◽  
Pentose Phosphate Pathway ◽  
Pentose Phosphate ◽  
Oxidative Pentose Phosphate Pathway ◽  
First Line ◽  
Skin Cells ◽  
Human Skin Cells

scholarly journals Proteins of the Extracellular Matrix Are Sensitizers of Photo-oxidative Stress in Human Skin Cells

2003 ◽  
Vol 121 (3) ◽  
pp. 578-586 ◽  
Author(s):  
Georg T. Wondrak ◽  
Michael J. Roberts ◽  
Daniel Cervantes-Laurean ◽  
Myron K. Jacobson ◽  
Elaine L. Jacobson
Keyword(s):  
Oxidative Stress ◽  
Extracellular Matrix ◽  
Human Skin ◽  
Skin Cells ◽  
Human Skin Cells

scholarly journals Beneficial effects of acute inhibition of the oxidative pentose phosphate pathway in the failing heart

2014 ◽  
Vol 306 (5) ◽  
pp. H709-H717 ◽  
Author(s):  
Claudio Vimercati ◽  
Khaled Qanud ◽  
Gianfranco Mitacchione ◽  
Danuta Sosnowska ◽  
Zoltan Ungvari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pentose Phosphate Pathway ◽  
Tissue Concentration ◽  
Glucose Consumption ◽  
Pentose Phosphate ◽  
Oxidative Pentose Phosphate Pathway ◽  
Stroke Work ◽  
Failing Heart

In vitro studies suggested that glucose metabolism through the oxidative pentose phosphate pathway (oxPPP) can paradoxically feed superoxide-generating enzymes in failing hearts. We therefore tested the hypothesis that acute inhibition of the oxPPP reduces oxidative stress and enhances function and metabolism of the failing heart, in vivo. In 10 chronically instrumented dogs, congestive heart failure (HF) was induced by high-frequency cardiac pacing. Myocardial glucose consumption was enhanced by raising arterial glycemia to levels mimicking postprandial peaks, before and after intravenous administration of the oxPPP inhibitor 6-aminonicotinamide (80 mg/kg). Myocardial energy substrate metabolism was measured with radiolabeled glucose and oleic acid, and cardiac 8-isoprostane output was used as an index of oxidative stress. A group of five chronically instrumented, normal dogs served as control. In HF, raising glycemic levels from ∼80 to ∼170 mg/dL increased cardiac isoprostane output by approximately twofold, whereas oxPPP inhibition normalized oxidative stress and enhanced cardiac oxygen consumption, glucose oxidation, and stroke work. In normal hearts glucose infusion did not induce significant changes in cardiac oxidative stress. Myocardial tissue concentration of 6P-gluconate, an intermediate metabolite of the oxPPP, was significantly reduced by ∼50% in treated versus nontreated failing hearts, supporting the inhibitory effect of 6-aminonicotinamide. Our study indicates an important contribution of the oxPPP activity to cardiac oxidative stress in HF, which is particularly pronounced during common physiological changes such as postprandial glycemic peaks.

MON-LB674: Dracocephalum Moldavica L. Seed Extracts Modulate Inflammation and Oxidative Stress in Human Skin Cells

2019 ◽  
Vol 38 ◽  
pp. S310
Author(s):  
E. Song ◽  
J. Choi ◽  
H. Gwon ◽  
S.-G. Choi ◽  
J. Chun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Skin ◽  
Skin Cells ◽  
Human Skin Cells ◽  
And Oxidative Stress ◽  
Seed Extracts

scholarly journals Can Light Emitted from Smartphone Screens and Taking Selfies Cause Premature Aging and Wrinkles?

2018 ◽  
Vol 8 (4Dec) ◽  
Author(s):  
N Arjmandi ◽  
Gh Mortazavi ◽  
S Zarei ◽  
M Faraz ◽  
S A R Mortazavi
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Visible Light ◽  
Human Skin ◽  
Blue Light ◽  
Biological Effects ◽  
Premature Aging ◽  
Oxygen Species ◽  
Skin Cells ◽  
Human Skin Cells

Since the early days of human life on the Earth, our skin has been exposed to different levels of light. Recently, due to inevitable consequences of modern life, humans are not exposed to adequate levels of natural light during the day but they are overexposed to relatively high levels of artificial light at night. Skin is a major target of oxidative stress and the link between aging and oxidative stress is well documented. Especially, extrinsic skin aging can be caused by oxidative stress. The widespread use of light emitting diodes (LEDs) and the rapidly increasing use of smartphones, tablets, laptops and desktop computers have led to a significant rise in the exposure of human eyes to short-wavelength visible light. Recent studies show that exposure of human skin cells to light emitted from electronic devices, even for exposures as short as 1 hour, may cause reactive oxygen species (ROS) generation, apoptosis, and necrosis. The biological effects of exposure to short-wavelength visible light in blue region in humans and other living organisms were among our research priorities at the Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC). Today, there is a growing concern over the safety of the light sources such as LEDs with peak emissions in the blue light range (400-490 nm). Recent studies aimed at investigating the effect of exposure to light emitted from electronic device on human skin cells, shows that even short exposures can increase the generation of reactive oxygen species. However, the biological effects of either long-term or repeated exposures are not fully known, yet. Furthermore, there are reports indicating that frequent exposure to visible light spectrum of the selfie flashes may cause skin damage and accelerated skin ageing. In this paper we have addressed the different aspects of potential effects of exposure to the light emitted from smartphones’ digital screens as well as smartphones’ photoflashes on premature aging of the human skin. Specifically, the effects of blue light on eyes and skin are discussed. Based on current knowledge, it can be suggested that changing the spectral output of LED-based smartphones’ flashes can be introduced as an effective method to reduce the adverse health effects associated with exposure to blue light.

scholarly journals Antioxidant and Cellular Protective Effects against Oxidative Stress of Calendula officinalis Flowers Extracts in Human Skin Cells

2016 ◽  
Vol 27 (6) ◽  
pp. 620-626 ◽  
Author(s):  
Song Hua Xuan ◽  
Ga Yoon Kim ◽  
Ji Yeon Yu ◽  
Jee Won Kim ◽  
Ye Rim Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Skin ◽  
Protective Effects ◽  
Calendula Officinalis ◽  
Skin Cells ◽  
Human Skin Cells

scholarly journals Can Light Emitted from Smartphone Screens and Taking Selfies Cause Premature Aging and Wrinkles?

2018 ◽  
Vol 8 (4 Dec) ◽  
Author(s):  
N Arjmandi ◽  
Gh Mortazavi ◽  
S Zarei ◽  
M Faraz ◽  
S A R Mortazavi
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Visible Light ◽  
Human Skin ◽  
Blue Light ◽  
Biological Effects ◽  
Premature Aging ◽  
Oxygen Species ◽  
Skin Cells ◽  
Human Skin Cells

Since the early days of human life on the Earth, our skin has been exposed to different levels of light. Recently, due to inevitable consequences of modern life, humans are not exposed to adequate levels of natural light during the day but they are overexposed to relatively high levels of artificial light at night. Skin is a major target of oxidative stress and the link between aging and oxidative stress is well documented. Especially, extrinsic skin aging can be caused by oxidative stress. The widespread use of light emitting diodes (LEDs) and the rapidly increasing use of smartphones, tablets, laptops and desktop computers have led to a significant rise in the exposure of human eyes to short-wavelength visible light. Recent studies show that exposure of human skin cells to light emitted from electronic devices, even for exposures as short as 1 hour, may cause reactive oxygen species (ROS) generation, apoptosis, and necrosis. The biological effects of exposure to short-wavelength visible light in blue region in humans and other living organisms were among our research priorities at the Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC). Today, there is a growing concern over the safety of the light sources such as LEDs with peak emissions in the blue light range (400-490 nm). Recent studies aimed at investigating the effect of exposure to light emitted from electronic device on human skin cells, shows that even short exposures can increase the generation of reactive oxygen species. However, the biological effects of either long-term or repeated exposures are not fully known, yet. Furthermore, there are reports indicating that frequent exposure to visible light spectrum of the selfie flashes may cause skin damage and accelerated skin ageing. In this paper we have addressed the different aspects of potential effects of exposure to the light emitted from smartphones’ digital screens as well as smartphones’ photoflashes on premature aging of the human skin. Specifically, the effects of blue light on eyes and skin are discussed. Based on current knowledge, it can be suggested that changing the spectral output of LED-based smartphones’ flashes can be introduced as an effective method to reduce the adverse health effects associated with exposure to blue light.

New cytokinin derivatives possess UVA and UVB photoprotective effect on human skin cells and prevent oxidative stress

2018 ◽  
Vol 150 ◽  
pp. 946-957 ◽  
Author(s):  
Martin Hönig ◽  
Lucie Plíhalová ◽  
Lukáš Spíchal ◽  
Jiří Grúz ◽  
Alena Kadlecová ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Skin ◽  
Skin Cells ◽  
Human Skin Cells
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