scholarly journals An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential

2014 ◽  
Vol 55 (3) ◽  
pp. 436-450 ◽  
Author(s):  
Jonathan M. Goodwin ◽  
Robert U. Svensson ◽  
Hua Jane Lou ◽  
Monte M. Winslow ◽  
Benjamin E. Turk ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Signaling Pathway ◽  
Metastatic Potential ◽  
Lkb1 Tumor Suppressor

scholarly journals TrkB-Induced Inhibition of R-SMAD/SMAD4 Activation is Essential for TGF-β-Mediated Tumor Suppressor Activity

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1048
Author(s):  
Min Soo Kim ◽  
Wook Jin
Keyword(s):  
Tumor Suppressor ◽  
Signaling Pathway ◽  
Tumor Suppression ◽  
Nuclear Translocation ◽  
Epithelial Mesenchymal Transition ◽  
Metastatic Potential ◽  
Suppressor Activity ◽  
Mesenchymal Transition ◽  
Stat3 Signaling Pathway ◽  
Tumor Suppressor Activity

TrkB-mediated activation of the IL6/JAK2/STAT3 signaling pathway is associated with the induction of the epithelial–mesenchymal transition (EMT) program and the acquisition of metastatic potential by tumors. Conversely, the transforming of growth factor-β (TGF-β) is implicated in tumor suppression through the canonical SMAD-dependent signaling pathway. Hence, TrkB could play a role in disrupting the potent TGF-β-mediated growth inhibition, a concept that has not been fully explored. Here, we identified TrkB to be a crucial regulator of the TGF-β signaling pathway as it inhibits the TGF-β-mediated tumor suppression and the activation of TrkB kinase. We further show that the interactions between TrkB and SMADs inhibit TGF-β-mediated R-SMAD/SMAD4 complex formation and suppress TGF-β-induced nuclear translocation and target gene expression. Additionally, the knockdown of TrkB restored the tumor inhibitory activity of TGF-β signaling. These observations suggest that interactions between TrkB and SMADs are critical for the inhibition of TGF-β tumor suppressor activity in cancer cells.

scholarly journals Entelon® (Vitis vinifera Seed Extract) Prevents Cancer Metastasis via the Downregulation of Interleukin-1 Alpha in Triple-Negative Breast Cancer Cells

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3644
Author(s):  
Daeun You ◽  
Yisun Jeong ◽  
Sun Young Yoon ◽  
Sung A Kim ◽  
Eunji Lo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signaling Pathway ◽  
Lung Metastasis ◽  
Triple Negative Breast Cancer ◽  
Cancer Metastasis ◽  
Triple Negative ◽  
Interleukin 1 ◽  
Metastatic Potential ◽  
Cancer Cell Proliferation ◽  
Dependent Pathway

Interleukin-1 (IL1) is a proinflammatory cytokine and promotes cancer cell proliferation and invasiveness in a diversity of cancers, such as breast and colon cancer. Here, we focused on the pharmacological effect of Entelon® (ETL) on the tumorigenesis of triple-negative breast cancer (TNBC) cells by IL1-alpha (IL1A). IL1A enhanced the cell growth and invasiveness of TNBC cells. We observed that abnormal IL1A induction is related with the poor prognosis of TNBC patients. IL1A also increased a variety of chemokines such as CCL2 and IL8. Interestingly, IL1A expression was reduced by the ETL treatment. Here, we found that ETL significantly decreased the MEK/ERK signaling pathway in TNBC cells. IL1A expression was reduced by UO126. Lastly, we studied the effect of ETL on the metastatic potential of TNBC cells. Our results showed that ETL significantly reduced the lung metastasis of TNBC cells. Our results showed that IL1A expression was regulated by the MEK/ERK- and PI3K/AKT-dependent pathway. Taken together, ETL inhibited the MEK/ERK and PI3K/AKT signaling pathway and suppressing the lung metastasis of TNBC cells through downregulation of IL1A. Therefore, we propose the possibility of ETL as an effective adjuvant for treating TNBC.

scholarly journals Osteoprotegerin Contributes to the Metastatic Potential of Cells with a Dysfunctional TSC2 Tumor-Suppressor Gene

2013 ◽  
Vol 183 (3) ◽  
pp. 938-950 ◽  
Author(s):  
Wendy K. Steagall ◽  
Gustavo Pacheco-Rodriguez ◽  
Connie G. Glasgow ◽  
Yoshihiko Ikeda ◽  
Jing-Ping Lin ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Metastatic Potential ◽  
Suppressor Gene

scholarly journals Expression and transcriptional profiling of the LKB1 tumor suppressor in cervical cancer cells

2014 ◽  
Vol 134 (2) ◽  
pp. 372-378 ◽  
Author(s):  
Xiaoli Zhang ◽  
Hanxiang Chen ◽  
Xiao Wang ◽  
Weiming Zhao ◽  
Jason J. Chen
Keyword(s):  
Cervical Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Transcriptional Profiling ◽  
Lkb1 Tumor Suppressor ◽  
Cervical Cancer Cells

scholarly journals The LKB1 tumor suppressor negatively regulates mTOR signaling

Cancer Cell ◽  
2004 ◽  
Vol 6 (1) ◽  
pp. 91-99 ◽  
Author(s):  
Reuben J Shaw ◽  
Nabeel Bardeesy ◽  
Brendan D Manning ◽  
Lyle Lopez ◽  
Monica Kosmatka ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Mtor Signaling ◽  
Lkb1 Tumor Suppressor
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