scholarly journals An Evolutionarily Conserved Long Noncoding RNA TUNA Controls Pluripotency and Neural Lineage Commitment

2014 ◽  
Vol 53 (6) ◽  
pp. 1067 ◽  
Author(s):  
Nianwei Lin ◽  
Kung-Yen Chang ◽  
Zhonghan Li ◽  
Keith Gates ◽  
Zacharia A. Rana ◽  
...  
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Lineage Commitment ◽  
Neural Lineage ◽  
Evolutionarily Conserved

scholarly journals An Evolutionarily Conserved Long Noncoding RNA TUNA Controls Pluripotency and Neural Lineage Commitment

2014 ◽  
Vol 53 (6) ◽  
pp. 1005-1019 ◽  
Author(s):  
Nianwei Lin ◽  
Kung-Yen Chang ◽  
Zhonghan Li ◽  
Keith Gates ◽  
Zacharia A. Rana ◽  
...  
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Lineage Commitment ◽  
Neural Lineage ◽  
Evolutionarily Conserved

scholarly journals Ancient exapted transposable elements promote nuclear enrichment of human long noncoding RNAs

2017 ◽  
Author(s):  
Joana Carlevaro-Fita ◽  
Taisia Polidori ◽  
Monalisa Das ◽  
Carmen Navarro ◽  
Tatjana I. Zoller ◽  
...  
Keyword(s):  
Transposable Elements ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Cell Types ◽  
Subcellular Localisation ◽  
Evolutionary Selection ◽  
Dependent Relationship ◽  
Evolutionarily Conserved ◽  
Show Evidence ◽  
Multiple Cell

AbstractThe sequence domains underlying long noncoding RNA (lncRNA) activities, including their characteristic nuclear enrichment, remain largely unknown. It has been proposed that these domains can originate from neofunctionalised fragments of transposable elements (TEs), otherwise known as RIDLs (Repeat Insertion Domains of Long Noncoding RNA), although just a handful have been identified. It is challenging to distinguish functional RIDL instances against a numerous genomic background of neutrally-evolving TEs. We here show evidence that a subset of TE types experience evolutionary selection in the context of lncRNA exons. Together these comprise an enrichment group of 5374 TE fragments in 3566 loci. Their host lncRNAs tend to be functionally validated and associated with disease. This RIDL group was used to explore the relationship between TEs and lncRNA subcellular localisation. Using global localisation data from ten human cell lines, we uncover a dose-dependent relationship between nuclear/cytoplasmic distribution, and evolutionarily-conserved L2b, MIRb and MIRc elements. This is observed in multiple cell types, and is unaffected by confounders of transcript length or expression. Experimental validation with engineered transgenes shows that these TEs drive nuclear enrichment in a natural sequence context. Together these data reveal a role for TEs in regulating the subcellular localisation of lncRNAs.

scholarly journals Spatiotemporal expression of long noncoding RNA Moshe modulates heart cell lineage commitment

RNA Biology ◽  
2021 ◽  
pp. 1-15
Author(s):  
Na-Jung Kim ◽  
Kang-Hoon Lee ◽  
YeonSung Son ◽  
A-Reum Nam ◽  
Eun-Hye Moon ◽  
...  
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Cell Lineage ◽  
Lineage Commitment ◽  
Heart Cell ◽  
Spatiotemporal Expression

scholarly journals Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment

Cell ◽  
2013 ◽  
Vol 152 (3) ◽  
pp. 570-583 ◽  
Author(s):  
Carla A. Klattenhoff ◽  
Johanna C. Scheuermann ◽  
Lauren E. Surface ◽  
Robert K. Bradley ◽  
Paul A. Fields ◽  
...  
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Lineage Commitment
Sign in / Sign up

Export Citation Format

Share Document