scholarly journals A WD-Repeat Protein Stabilizes ORC Binding to Chromatin

2010 ◽  
Vol 40 (1) ◽  
pp. 99-111 ◽  
Author(s):  
Zhen Shen ◽  
Kizhakke M. Sathyan ◽  
Yijie Geng ◽  
Ruiping Zheng ◽  
Arindam Chakraborty ◽  
...  
Keyword(s):  
Repeat Protein ◽  
Wd Repeat

scholarly journals The Essential WD Repeat Protein Swd2 Has Dual Functions in RNA Polymerase II Transcription Termination and Lysine 4 Methylation of Histone H3

2004 ◽  
Vol 24 (7) ◽  
pp. 2932-2943 ◽  
Author(s):  
Hailing Cheng ◽  
Xiaoyuan He ◽  
Claire Moore
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Chromatin Modification ◽  
Histone H3 ◽  
Temperature Sensitive ◽  
Repeat Protein ◽  
Tightly Coupled ◽  
Cleavage And Polyadenylation ◽  
Wd Repeat

ABSTRACT Swd2, an essential WD repeat protein in Saccharomyces cerevisiae, is a component of two very different complexes: the cleavage and polyadenylation factor CPF and the Set1 methylase, which modifies lysine 4 of histone H3 (H3-K4). It was not known if Swd2 is important for the function of either of these entities. We show here that, in extract from cells depleted of Swd2, cleavage and polyadenylation of the mRNA precursor in vitro are completely normal. However, temperature-sensitive mutations or depletion of Swd2 causes termination defects in some genes transcribed by RNA polymerase II. Overexpression of Ref2, a protein previously implicated in snoRNA 3′ end formation and Swd2 recruitment to CPF, can rescue the growth and termination defects, indicating a functional interaction between the two proteins. Some swd2 mutations also significantly decrease global H3-K4 methylation and cause other phenotypes associated with loss of this chromatin modification, such as loss of telomere silencing, hydroxyurea sensitivity, and alterations in repression of INO1 transcription. Even though the two Swd2-containing complexes are both localized to actively transcribed genes, the allele specificities of swd2 defects suggest that the functions of Swd2 in mediating RNA polymerase II termination and H3-K4 methylation are not tightly coupled.

scholarly journals Crystal structure of Ski8p, a WD-repeat protein with dual roles in mRNA metabolism and meiotic recombination

2009 ◽  
Vol 13 (10) ◽  
pp. 2673-2684 ◽  
Author(s):  
Zhihong Cheng ◽  
Yuying Liu ◽  
Chernhoe Wang ◽  
Roy Parker ◽  
Haiwei Song
Keyword(s):  
Crystal Structure ◽  
Meiotic Recombination ◽  
Dual Roles ◽  
Repeat Protein ◽  
Mrna Metabolism ◽  
Wd Repeat

scholarly journals The Novel WD-repeat Protein Morg1 Acts as a Molecular Scaffold for Hypoxia-inducible Factor Prolyl Hydroxylase 3 (PHD3)

2006 ◽  
Vol 281 (13) ◽  
pp. 8645-8655 ◽  
Author(s):  
Ulrike Hopfer ◽  
Helmut Hopfer ◽  
Katarina Jablonski ◽  
Rolf A. K. Stahl ◽  
Gunter Wolf
Keyword(s):  
Hypoxia Inducible Factor ◽  
Prolyl Hydroxylase ◽  
The Novel ◽  
Molecular Scaffold ◽  
Repeat Protein ◽  
Wd Repeat

scholarly journals A Novel WD Repeat Protein Component of the Methylosome Binds Sm Proteins

2001 ◽  
Vol 277 (10) ◽  
pp. 8243-8247 ◽  
Author(s):  
Westley J. Friesen ◽  
Anastasia Wyce ◽  
Sergey Paushkin ◽  
Linda Abel ◽  
Juri Rappsilber ◽  
...  
Keyword(s):  
Protein Component ◽  
Sm Proteins ◽  
Repeat Protein ◽  
Wd Repeat

Mapping and Structure of DMXL1, a Human Homologue of the DmX Gene from Drosophila melanogaster Coding for a WD Repeat Protein

Genomics ◽  
2000 ◽  
Vol 64 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Christiane Kraemer ◽  
Thorsten Enklaar ◽  
Bernhard Zabel ◽  
Erwin R. Schmidt
Keyword(s):  
Drosophila Melanogaster ◽  
Human Homologue ◽  
Repeat Protein ◽  
Wd Repeat

scholarly journals Regulation of the p21-activated kinase (PAK) by a human G -like WD-repeat protein, hPIP1

2001 ◽  
Vol 98 (11) ◽  
pp. 6174-6179 ◽  
Author(s):  
C. Xia ◽  
W. Ma ◽  
L. J. Stafford ◽  
S. Marcus ◽  
W.-C. Xiong ◽  
...  
Keyword(s):  
Repeat Protein ◽  
Wd Repeat ◽  
P21 Activated Kinase

scholarly journals Purification of a WD Repeat Protein, EMAP, That Promotes Microtubule Dynamics through an Inhibition of Rescue

1998 ◽  
Vol 273 (15) ◽  
pp. 9285-9291 ◽  
Author(s):  
Danielle R. Hamill ◽  
Bonnie Howell ◽  
Lynne Cassimeris ◽  
Kathy A. Suprenant
Keyword(s):  
Microtubule Dynamics ◽  
Repeat Protein ◽  
Wd Repeat
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