scholarly journals An AT-Rich Sequence in Human Common Fragile Site FRA16D Causes Fork Stalling and Chromosome Breakage in S. cerevisiae

2007 ◽  
Vol 27 (3) ◽  
pp. 367-379 ◽  
Author(s):  
Haihua Zhang ◽  
Catherine H. Freudenreich
Keyword(s):  
Fragile Site ◽  
Chromosome Breakage ◽  
Common Fragile Site ◽  
Fork Stalling

scholarly journals Werner syndrome helicase activity is essential in maintaining fragile site stability

2008 ◽  
Vol 180 (2) ◽  
pp. 305-314 ◽  
Author(s):  
Livia Maria Pirzio ◽  
Pietro Pichierri ◽  
Margherita Bignami ◽  
Annapaola Franchitto
Keyword(s):  
Werner Syndrome ◽  
Fragile Site ◽  
Chromosome Breakage ◽  
Fragile Sites ◽  
Helicase Activity ◽  
Dna Helicases ◽  
Replication Checkpoint ◽  
Replicative Stress ◽  
Fork Stalling ◽  
The Stability

WRN is a member of the RecQ family of DNA helicases implicated in the resolution of DNA structures leading to the stall of replication forks. Fragile sites have been proposed to be DNA regions particularly sensitive to replicative stress. Here, we establish that WRN is a key regulator of fragile site stability. We demonstrate that in response to mild doses of aphidicolin, WRN is efficiently relocalized in nuclear foci in replicating cells and that WRN deficiency is associated with accumulation of gaps and breaks at common fragile sites even under unperturbed conditions. By expressing WRN isoforms impaired in either helicase or exonuclease activity in defective cells, we identified WRN helicase activity as the function required for maintaining the stability of fragile sites. Finally, we find that WRN stabilizes fragile sites acting in a common pathway with the ataxia telangiectasia and Rad3 related replication checkpoint. These findings provide the first evidence of a crucial role for a helicase in protecting cells against chromosome breakage at normally occurring replication fork stalling sites.

scholarly journals Translocation t(3;8)(p14.2;q24.1) in renal cell carcinoma affects expression of the common fragile site at 3p14(FRA3B) in lymphocytes

1988 ◽  
Vol 31 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Thomas W. Glover ◽  
Jane F. Coyle-Morris ◽  
Frederick P. Li ◽  
Robert S. Brown ◽  
Carol S. Berger ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Fragile Site ◽  
Common Fragile Site ◽  
The Common

The FRA14B common fragile site maps to a region prone to somatic and germline rearrangements within the large GPHN gene

2018 ◽  
Vol 58 (5) ◽  
pp. 284-294
Author(s):  
Diana Zheglo ◽  
Lena M. Brueckner ◽  
Olga Sepman ◽  
Elisa M. Wecht ◽  
Ekaterina Kuligina ◽  
...  
Keyword(s):  
Fragile Site ◽  
Common Fragile Site

scholarly journals Common fragile site instability in normal cells: Lessons and perspectives

2018 ◽  
Vol 58 (5) ◽  
pp. 260-269 ◽  
Author(s):  
Elisa Palumbo ◽  
Antonella Russo
Keyword(s):  
Fragile Site ◽  
Common Fragile Site ◽  
Normal Cells

The common fragile site FRA16D and its associated geneWWOX are highly conserved in the mouse at Fra8E1

2002 ◽  
Vol 34 (2) ◽  
pp. 154-167 ◽  
Author(s):  
Kurt A. Krummel ◽  
Stacy R. Denison ◽  
Eric Calhoun ◽  
Leslie A. Phillips ◽  
David I. Smith
Keyword(s):  
Fragile Site ◽  
Common Fragile Site ◽  
The Common
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