scholarly journals Endonuclease G Regulates Budding Yeast Life and Death

2007 ◽  
Vol 25 (2) ◽  
pp. 233-246 ◽  
Author(s):  
Sabrina Büttner ◽  
Tobias Eisenberg ◽  
Didac Carmona-Gutierrez ◽  
Doris Ruli ◽  
Heide Knauer ◽  
...  
Keyword(s):  
Budding Yeast ◽  
Endonuclease G ◽  
Life And Death

scholarly journals The Many Faces of Mitochondrial Autophagy: Making Sense of Contrasting Observations in Recent Research

2012 ◽  
Vol 2012 ◽  
pp. 1-18 ◽  
Author(s):  
Alexander I. May ◽  
Rodney J. Devenish ◽  
Mark Prescott
Keyword(s):  
Budding Yeast ◽  
Eukaryotic Cell ◽  
Current Understanding ◽  
Eukaryotic Cells ◽  
Experimental Conditions ◽  
Life And Death ◽  
Function Mechanism ◽  
Making Sense ◽  
Autophagic Degradation ◽  
The Many

Research into the selective autophagic degradation of mitochondria—mitophagy—has intensified in recent years, yielding significant insights into the function, mechanism, and regulation of this process in the eukaryotic cell. However, while some molecular players in budding yeast, such as Atg32p, Uth1p, and Aup1p, have been identified, studies further interrogating the mechanistic and regulatory features of mitophagy have yielded inconsistent and sometimes conflicting results. In this review, we focus on the current understanding of mitophagy mechanism, induction, and regulation in yeast, and suggest that differences in experimental conditions used in the various studies of mitophagy may contribute to the observed discrepancies. Consideration and understanding of these differences may help place the mechanism and regulation of mitophagy in context, and further indicate the intricate role that this essential process plays in the life and death of eukaryotic cells.

scholarly journals Meiotic viral attenuation through an ancestral apoptotic pathway

2019 ◽  
Vol 116 (33) ◽  
pp. 16454-16462 ◽  
Author(s):  
Jie Gao ◽  
Sabrina Chau ◽  
Fuad Chowdhury ◽  
Tina Zhou ◽  
Saif Hossain ◽  
...  
Keyword(s):  
Budding Yeast ◽  
Apoptotic Pathway ◽  
Double Stranded Rna ◽  
Endonuclease G ◽  
Dying Cells ◽  
Viral Attenuation ◽  
Programmed Release

The programmed release of apoptogenic proteins from mitochondria is a core event of apoptosis, although ancestral roles of this phenomenon are not known. In mammals, one such apoptogenic protein is Endonuclease G (EndoG), a conserved mitochondrial nuclease that fragments the DNA of dying cells. In this work, we show that budding yeast executes meiotically programmed mitochondrial release of an EndoG homolog, Nuc1, during sporulation. In contrast to EndoG’s ostensible pro-death function during apoptosis, Nuc1 mitochondrial release is pro-survival, attenuating the cytosolic L-A and Killer double-stranded RNA mycoviruses and protecting meiotic progeny from the catastrophic consequences of their derepression. The protective viral attenuation role of this pathway illuminates a primordial role for mitochondrial release of EndoG, and perhaps of apoptosis itself.

scholarly journals Meiotic viral attenuation through an ancestral apoptotic pathway

2019 ◽  
Author(s):  
Jie Gao ◽  
Sabrina Chau ◽  
Fuad Chowdhury ◽  
Tina Zhou ◽  
Saif Hossain ◽  
...  
Keyword(s):  
Budding Yeast ◽  
Apoptotic Pathway ◽  
Endonuclease G ◽  
Dying Cells ◽  
Viral Attenuation ◽  
Dsrna Mycovirus ◽  
Programmed Release

AbstractThe programmed release of apoptogenic proteins from mitochondria is a core event of apoptosis, though ancestral roles of this phenomenon are not known. In mammals, one such apoptogenic protein is Endonuclease G (EndoG), a conserved nuclease that fragments the DNA of dying cells. In this work, we show that budding yeast executes meiotically programmed mitochondrial release of an EndoG homologue, Nuc1, during sporulation. In contrast to EndoG’s ostensible pro-death function during apoptosis, Nuc1 mitochondrial release attenuates the cytosolic dsRNA mycovirus, Killer, protecting spores from a lethal accumulation of its encoded toxin. Our identification of cell-protective viral attenuation as a target of this rudimentary apoptotic pathway illuminates a primordial role for mitochondrial release of EndoG.One Sentence SummaryYeast sporulation induces release of mitochondrial endonuclease G to accomplish viral attenuation.

Friends in Life and Death

1992 ◽  
Author(s):  
Richard T. Vann ◽  
David Eversley
Keyword(s):  
Life And Death

Humanizing time, love, life, and death: An allegory set between the eternities.

PsycCRITIQUES ◽  
2009 ◽  
Vol 54 (35) ◽  
Author(s):  
Frank Farley ◽  
Debbie Joffe Ellis
Keyword(s):  
Life And Death ◽  
Love Life
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