CAA insertion polymorphism in the 3′UTR of Nogo gene on 2p14 is not associated with schizophrenia

2005 ◽  
Vol 133 (1) ◽  
pp. 153-156 ◽  
Author(s):  
Lan Xiong ◽  
Guy A. Rouleau ◽  
Lynn E. DeLisi ◽  
Judith St-Onge ◽  
Robert Najafee ◽  
...  
Keyword(s):  
Insertion Polymorphism ◽  
Nogo Gene

scholarly journals Phylogenetic relationships among accessions in Citrus and related genera based on the insertion polymorphism of the CIRE1 retrotransposon

2020 ◽  
Vol 5 (1) ◽  
pp. 243-251
Author(s):  
Akira Horibata ◽  
Tsuneo Kato
Keyword(s):  
Phylogenetic Relationships ◽  
Sweet Orange ◽  
Point Of View ◽  
Insertion Polymorphism ◽  
Navel Orange ◽  
Citrus Germplasm ◽  
Outgroup Species ◽  
Blood Orange

AbstractA total of 145 accessions of the genus Citrus and related genera, maintained in the Conservation Garden for Citrus Germplasm at the Experimental Farm of Kindai University, Yuasa, Wakayama, Japan, were examined for their phylogenetic relationships. The present classification was conducted using an inter-retrotransposon amplified polymorphism (IRAP) method based on the insertion polymorphism of a retrotransposon, CIRE1, identified in C. sinensis. The objective of this study was to evaluate the applicability of the IRAP method for citrus classification. The constructed dendrogram showed that the 145 accessions and two outgroup species were successfully classified into five major clades. A large number of C. sinensis accessions were divided into three traditional groups, navel orange, sweet orange, and blood orange, almost corresponding to the sub-clades in the dendrogram. Several other accessions belonging to the same species, and also many hybrid cultivars from crossbreeding, were localized into the respective sub-clades or near positions in the dendrogram. Several unclassified accessions could also be located in the dendrogram, suggesting novel relationships with other accessions. It was concluded that the IRAP method based on CIRE1 insertion polymorphism was suitable for the classification of citrus from a molecular point of view.

SINE insertion polymorphism on the X chromosome differentiates Anopheles gambiae molecular forms

2005 ◽  
Vol 14 (4) ◽  
pp. 353-363 ◽  
Author(s):  
M. J. Barnes ◽  
N. F. Lobo ◽  
M. B. Coulibaly ◽  
N'F. Sagnon ◽  
C. Costantini ◽  
...  
Keyword(s):  
Anopheles Gambiae ◽  
X Chromosome ◽  
Molecular Forms ◽  
Insertion Polymorphism ◽  
Sine Insertion

A 9.1-kb Gap in the Genome Reference Map Is Shown to Be a Stable Deletion/Insertion Polymorphism of Ancestral Origin

Genomics ◽  
2002 ◽  
Vol 80 (6) ◽  
pp. 585-592 ◽  
Author(s):  
Renato Robledo ◽  
Sandro Orru ◽  
Antonella Sidoti ◽  
Rosella Muresu ◽  
Diane Esposito ◽  
...  
Keyword(s):  
Insertion Polymorphism ◽  
Ancestral Origin ◽  
Reference Map

CTG repeats distribution and Alu insertion polymorphism at myotonic dystrophy (DM) gene in Amhara and Oromo populations of Ethiopia

1999 ◽  
Vol 105 (1-2) ◽  
pp. 165-167 ◽  
Author(s):  
M. Gennarelli ◽  
M. Pavoni ◽  
F. Cruciani ◽  
G. De Stefano ◽  
B. Dallapiccola ◽  
...  
Keyword(s):  
Myotonic Dystrophy ◽  
Insertion Polymorphism ◽  
Ctg Repeats ◽  
Alu Insertion

Abstract 051: A Panel of CRISPR/Cas9 Genome Edited Rat Models Define Quantitative Trait Nucleotides within a Novel Rat Long Non-coding RNA Implicated in Cardiovascular Disease

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Xi Cheng ◽  
Harshal Waghulde ◽  
Blair Mell ◽  
Shondra Miller ◽  
Wanda Filipiak ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Quantitative Trait ◽  
Qt Interval ◽  
Chromosome 17 ◽  
Insertion Polymorphism ◽  
Non Coding Rna ◽  
Trait Locus ◽  
Human Chromosome 17 ◽  
Long Non Coding Rna

This study is focused on a GWAS locus for cardiovascular disease (QT-interval) on human chromosome 17. The homologous genomic segment of this human locus was previously mapped with high resolution to <42.5 kb on rat chromosome 10. The locus in rats regulates both QT-interval and blood pressure and contains a novel long non-coding RNA (lncRNA), with a large 19bp deletion/insertion polymorphism observed between the strains used to map the locus. Characterization of this novel lncRNA using rapid amplification of cDNA ends (RACE) provided evidence for the presence of more than a single isoform of the lncRNA. To further assess the role of this locus, a panel of CRISPR/Cas9 based gene-edited ‘knockout’ models of the lncRNA was developed. The lncRNA targeted rats were developed on the genomic background of the hypertensive Dahl salt-sensitive rats and harbored varied disruptions around the critical 19bp region. The rat strains with the disrupted lncRNA sequences had a significantly elevated blood pressure compared with the controls. QT-interval is currently being examined. Overall, this is the first demonstration of a CRISPR/Cas9 based targeted gene-editing approach applied to identify a novel lncRNA as a Blood Pressure Quantitative Trait Locus.

scholarly journals Cell line fingerprinting using retroelement insertion polymorphism

BioTechniques ◽  
2005 ◽  
Vol 38 (4) ◽  
pp. 561-565 ◽  
Author(s):  
Svetlana V. Ustyugova ◽  
Anna L. Amosova ◽  
Yuri B. Lebedev ◽  
Eugene D. Sverdlov
Keyword(s):  
Cell Line ◽  
Insertion Polymorphism

scholarly journals A SINE-VNTR-Alu in the LRIG2 Promoter Is Associated with Gene Expression at the Locus

2020 ◽  
Vol 21 (22) ◽  
pp. 8486
Author(s):  
Ashley Hall ◽  
Anni K. Moore ◽  
Dena G. Hernandez ◽  
Kimberley J. Billingsley ◽  
Vivien J. Bubb ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Genomic Variation ◽  
Insertion Polymorphism ◽  
Rna Seq ◽  
The North ◽  
Allele Dosage ◽  
Brain Expression ◽  
Epigenetic Modulation ◽  
Leucine Rich Repeats ◽  
Human Specific

The hominid SINE-VNTR-Alu (SVA) retrotransposons represent a repertoire of genomic variation which could have significant effects on genome function. A human-specific SVA in the promoter region of the gene leucine-rich repeats and immunoglobulin-like domains 2 (LRIG2), which we termed SVA_LRIG2, is a common retrotransposon insertion polymorphism (RIP), defined as an element which is polymorphic for its presence or absence in the genome. We hypothesised that this RIP might be associated with differential levels of expression of LRIG2. The RIP genotype of SVA_LRIG2 was determined in a subset of frontal cortex DNA samples from the North American Brain Expression Consortium (NABEC) cohort and was imputed for a larger set of that cohort. Utilising available frontal cortex total RNA-seq and CpG methylation data for this cohort, we observed that increased allele dosage of SVA_LRIG2 was non-significantly associated with a decrease in transcription from the region and significantly associated with increased methylation of the CpG probe nearest to SVA_LRIG2, i.e., SVA_LRIG2 is a significant methylation quantitative trait loci (mQTL) at the LRIG2 locus. These data are consistent with SVA_LRIG2 being a transcriptional regulator, which in part may involve epigenetic modulation.

scholarly journals HLA-G14 bp deletion/insertion polymorphism and mother-to-child transmission of HIV

2014 ◽  
Vol 83 (3) ◽  
pp. 161-167 ◽  
Author(s):  
L. Segat ◽  
L. Zupin ◽  
H.-Y. Kim ◽  
E. Catamo ◽  
D. M. Thea ◽  
...  
Keyword(s):  
Insertion Polymorphism ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Mother To Child
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