Cloning and developmental expression of a chick G-protein-coupled receptor SCGPR1

2007 ◽  
Vol 7 (4) ◽  
pp. 375-380 ◽  
Author(s):  
Noritaka Odani ◽  
Samuel L. Pfaff ◽  
Harukazu Nakamura ◽  
Jun-ichi Funahashi
Keyword(s):  
G Protein ◽  
Developmental Expression ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Developmental Expression of Orphan G Protein-Coupled Receptor 50 in the Mouse Brain

2012 ◽  
Vol 3 (6) ◽  
pp. 459-472 ◽  
Author(s):  
Ellen Grünewald ◽  
Kenneth D. Tew ◽  
David J. Porteous ◽  
Pippa A. Thomson
Keyword(s):  
G Protein ◽  
Mouse Brain ◽  
Developmental Expression ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Developmental expression of the G protein-coupled receptor 54 and three GnRH mRNAs in the teleost fish cobia

2007 ◽  
Vol 38 (2) ◽  
pp. 235-244 ◽  
Author(s):  
J Shaik Mohamed ◽  
Abby D Benninghoff ◽  
G Joan Holt ◽  
Izhar A Khan
Keyword(s):  
G Protein ◽  
Teleost Fish ◽  
Expression Patterns ◽  
Developmental Expression ◽  
Mrna Levels ◽  
G Protein Coupled Receptor ◽  
Early Puberty ◽  
Cdna Sequences ◽  
Gnrh Release ◽  
G Protein Coupled

The cDNAs of the G protein-coupled receptor 54 (GPR54) and three prepro-gonadotropin-releasing hormones, GnRH-I (seabream GnRH), GnRH-II (chicken GnRH-II), and GnRH-III (salmon GnRH) were isolated and cloned from the brain of the teleost fish cobia, Rachycentron canadum. The cobia GPR54 cDNA was 95 and 51–56% identical to those of tilapia and mammalian models respectively. The GnRH cDNA sequences of cobia showed strong identities to those of tilapia, Atlantic croaker, red drum, and the seabass and seabream species. The real-time quantitative RT-PCR methods allowed detection of all three GnRH mRNAs on the first day after hatching (DAH). The GnRH-I mRNA levels, which were the lowest among the three GnRHs, increased gradually with two distinct peaks in larvae at 3 and 4 DAH. On the other hand, GnRH-II and GnRH-III mRNAs were significantly higher in larvae at 2 and 6 DAH compared with those on the preceding days. In addition, significant peaks of all the three GnRH mRNAs were observed in the brains of 26-day-old fish. The finding of higher GnRH-I and GnRH-II mRNAs in males than females at 153 DAH may be related to early puberty observed during the first year in laboratory-reared male cobia. Moreover, this study demonstrates for the first time the expression of GPR54 mRNA during larval development in a vertebrate species. The concomitant expression patterns of GPR54 and GnRH mRNAs during different stages of larval and juvenile developments, and during early puberty in male cobia suggest a potential relationship between GPR54 and multiple GnRHs during these stages of development consistent with the role of GPR54 in controlling GnRH release in mammals. The increase in GPR54 and GnRH mRNAs observed during early puberty in cobia is consistent with a similar change reported in pubertal rats. This finding together with the localization of GPR54 mRNAs on GnRH neurons in fish and mammals suggests that the GPR54–GnRH interactions may be conserved in different vertebrate groups.

Vanadium compounds cause activation of G protein-coupled receptor signaling

2020 ◽  
Author(s):  
Debbie C. Crans ◽  
Duaa Althumairy ◽  
Heide Murakami ◽  
B. George Barisas ◽  
Deborah Roess
Keyword(s):  
G Protein ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
Vanadium Compounds ◽  
G Protein Coupled

Involvement of the constitutive activity of the GHS-R1a (ghrelin G-protein coupled receptor) in the tumorigenesis of somatotroph adenomas

2013 ◽  
Author(s):  
Yves Louis Mear ◽  
Xavier Come Donato ◽  
Marie Pierre Blanchard ◽  
Celine Defilles ◽  
Christophe Lisbonis ◽  
...  
Keyword(s):  
G Protein ◽  
Constitutive Activity ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled
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