Developmentally regulated expression of the LRRTM gene family during mid-gestation mouse embryogenesis

2007 ◽  
Vol 7 (1-2) ◽  
pp. 23-29 ◽  
Author(s):  
Bryan P. Haines ◽  
Peter W.J. Rigby
Keyword(s):  
Gene Family ◽  
Developmentally Regulated ◽  
Mouse Embryogenesis ◽  
Regulated Expression

scholarly journals Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family

BMC Genomics ◽  
2008 ◽  
Vol 9 (1) ◽  
pp. 89 ◽  
Author(s):  
Iain W Chalmers ◽  
Andrew J McArdle ◽  
Richard MR Coulson ◽  
Marissa A Wagner ◽  
Ralf Schmid ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Schistosoma Mansoni ◽  
Gene Family ◽  
Developmentally Regulated ◽  
Regulated Expression ◽  
Venom Allergen

scholarly journals Developmentally regulated Drosophila gene family encoding the fork head domain.

1992 ◽  
Vol 89 (18) ◽  
pp. 8754-8758 ◽  
Author(s):  
U. Hacker ◽  
U. Grossniklaus ◽  
W. J. Gehring ◽  
H. Jackle
Keyword(s):  
Gene Family ◽  
Developmentally Regulated ◽  
Drosophila Gene ◽  
Fork Head ◽  
Head Domain

Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene

1988 ◽  
Vol 8 (4) ◽  
pp. 1853-1856
Author(s):  
M Takahashi ◽  
Y Inaguma ◽  
H Hiai ◽  
F Hirose
Keyword(s):  
Human Gene ◽  
Mrna Levels ◽  
Nucleic Acid Binding ◽  
Developmentally Regulated ◽  
Unique Transcript ◽  
Binding Domains ◽  
Regulated Expression ◽  
Pachytene Spermatocytes ◽  
Human Finger ◽  
Transforming Gene

We isolated and sequenced a cDNA clone of the human gene encoded by the 5' half of the ret transforming gene. The nucleotide sequence indicates that it encodes a protein with "finger" structures which represent putative metal- and nucleic acid-binding domains. Transcription of this gene was detected at high levels in a variety of human and rodent tumor cell lines, mouse testis, and embryos. In addition, a unique transcript was observed in testis RNA. When the expression of the unique transcript was examined at different stages of spermatogenesis, a striking increase in mRNA levels accompanied progression from meiotic prophase pachytene spermatocytes to postmeiotic round spermatids. This finger-containing gene may thus function in male germ cell development.

Multiple regulatory genes control expression of a gene family during development of Dictyostelium discoideum

1986 ◽  
Vol 6 (12) ◽  
pp. 4353-4361
Author(s):  
S Alexander ◽  
A M Cibulsky ◽  
S D Cuneo
Keyword(s):  
Gene Family ◽  
Dictyostelium Discoideum ◽  
Regulatory Genes ◽  
Developmental Expression ◽  
Developmentally Regulated ◽  
Suppressor Activity ◽  
Normal Expression ◽  
Mutant Strains ◽  
Complementation Groups ◽  
In Trans

Mutant strains of Dictyostelium discoideum carrying dis mutations fail to transcribe specifically the family of developmentally regulated discoidin lectin genes during morphogenesis. The phenotypes of these mutants strongly suggested that the mutations reside in regulatory genes. Using these mutant strains, we showed that multiple regulatory genes are required for the expression of the lectin structural genes and that these regulatory genes (the dis+ alleles) act in trans to regulate this gene family. These regulatory genes fall into two complementation groups (disA and disB) and map to linkage groups II and III, respectively. A further regulatory locus was defined by the identification of an unlinked supressor gene, drsA (discoidin restoring), which is epistatic to disB, but not disA, and results in the restoration of lectin expression in cells carrying the disB mutation. Mutant cells carrying the drsA allele express the discoidin lectin gene family during growth and development, in contrast to wild-type cells which express it only during development. Therefore, the suppressor activity of the drsA allele appears to function by making the expression of the discoidin lectins constitutive and no longer strictly developmentally regulated. The data indicate that normal expression of the discoidin lectins is dependent on the sequential action of the disB+, drsA+, and disA+ gene products. Thus, we described an interacting network of regulatory genes which in turn controls the developmental expression of a family of genes during the morphogenesis of D. discoideum.

scholarly journals Growth-regulated expression of rhoG, a new member of the ras homolog gene family.

1992 ◽  
Vol 12 (7) ◽  
pp. 3138-3148 ◽  
Author(s):  
S Vincent ◽  
P Jeanteur ◽  
P Fort
Keyword(s):  
Gene Family ◽  
Transcriptional Activation ◽  
Small Gtpase ◽  
Lung Fibroblasts ◽  
Human Organs ◽  
Regulated Expression ◽  
Genes Encoding ◽  
Rna Stabilization ◽  
Rna Accumulation ◽  
High Level

Cellular transition from the resting state to DNA synthesis involves master switches genes encoding transcriptional factors (e.g., fos, jun, and egr genes), whose targets remain to be fully characterized. To isolate coding sequences specifically accumulated in late G1, a differential screening was performed on a cDNA library prepared from hamster lung fibroblasts stimulated for 5 h with serum. One of the positive clones which displayed a sevenfold induction, turned out to code for a protein sharing homology to Ras-like products. Cloning and sequence analysis of the human homolog revealed that this putative new small GTPase, referred to as rhoG, is more closely related to the rac, CDC42, and TC10 members of the rho (ras homolog) gene family and might have diverged very early during evolution. rhoG mRNA accumulates in proportion to the mitogenic strength of various purified growth factors used for the stimulation, as a consequence of transcriptional activation. G1-specific RNA accumulation is impaired upon addition of antimitogenic cyclic AMP and is enhanced when protein synthesis is inhibited, mainly as a result of RNA stabilization. rhoG mRNA expression is observed in a wide variety of human organs but reaches a particularly high level in lung and placental tissues.

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