scholarly journals Roles of basal keratinocytes in actinotrichia formation

2018 ◽  
Vol 153 ◽  
pp. 54-63 ◽  
Author(s):  
Junpei Kuroda ◽  
Atsuko H. Iwane ◽  
Shigeru Kondo
Keyword(s):  
Basal Keratinocytes

scholarly journals Overexpression of PD‐L1 in gingival basal keratinocytes reduces periodontal inflammation in a ligature‐induced periodontitis model

2021 ◽  
Author(s):  
Keeratika Wongtim ◽  
Eri Ikeda ◽  
Tatsukuni Ohno ◽  
Shigenori Nagai ◽  
Shigeru Okuhara ◽  
...  
Keyword(s):  
Basal Keratinocytes ◽  
Periodontal Inflammation

Onset of Epidermal Differentiation in Rapidly Proliferating Basal Keratinocytes

1986 ◽  
Vol 87 (4) ◽  
pp. 472-476 ◽  
Author(s):  
Marcelle Régnier ◽  
Pierre Vaigot ◽  
Michel Darmon ◽  
Michel Pruniéras
Keyword(s):  
Epidermal Differentiation ◽  
Basal Keratinocytes

scholarly journals PKK deletion in basal keratinocytes promotes tumorigenesis after chemical carcinogenesis

2017 ◽  
Vol 39 (3) ◽  
pp. 418-428 ◽  
Author(s):  
Luojing Chen ◽  
Matthew S Hayden ◽  
Elaine S Gilmore ◽  
Carolina Alexander-Savino ◽  
David Oleksyn ◽  
...  
Keyword(s):  
Chemical Carcinogenesis ◽  
Basal Keratinocytes

A Surface Glycoprotein Complex Related to the Adhesive Receptors of the VLA Family, Shared by Epidermal Langerhans Cells and Basal Keratinocytes.

1989 ◽  
Vol 92 (5) ◽  
pp. 739-745 ◽  
Author(s):  
Marie J. Staquet ◽  
Colette Dezutter-Dambuyant ◽  
Daniel Schmitt ◽  
Martine Amiot ◽  
Laurence Boumsell ◽  
...  
Keyword(s):  
Langerhans Cells ◽  
Surface Glycoprotein ◽  
Basal Keratinocytes ◽  
Glycoprotein Complex ◽  
Epidermal Langerhans Cells

scholarly journals Differential Role of Basal Keratinocytes in UV-Induced Immunosuppression and Skin Cancer

2006 ◽  
Vol 26 (22) ◽  
pp. 8515-8526 ◽  
Author(s):  
Judith Jans ◽  
George A. Garinis ◽  
Wouter Schul ◽  
Adri van Oudenaren ◽  
Michael Moorhouse ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Biological Effects ◽  
Mouse Skin ◽  
Cell Type ◽  
Cell Type Specificity ◽  
Basal Keratinocytes ◽  
Expression Of Genes ◽  
Pyrimidine Dimers ◽  
Response To Stress

ABSTRACT Cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs) comprise major UV-induced photolesions. If left unrepaired, these lesions can induce mutations and skin cancer, which is facilitated by UV-induced immunosuppression. Yet the contribution of lesion and cell type specificity to the harmful biological effects of UV exposure remains currently unclear. Using a series of photolyase-transgenic mice to ubiquitously remove either CPDs or 6-4PPs from all cells in the mouse skin or selectively from basal keratinocytes, we show that the majority of UV-induced acute effects to require the presence of CPDs in basal keratinocytes in the mouse skin. At the fundamental level of gene expression, CPDs induce the expression of genes associated with repair and recombinational processing of DNA damage, as well as apoptosis and a response to stress. At the organismal level, photolyase-mediated removal of CPDs, but not 6-4PPs, from the genome of only basal keratinocytes substantially diminishes the incidence of skin tumors; however, it does not affect the UVB-mediated immunosuppression. Taken together, these findings reveal a differential role of basal keratinocytes in these processes, providing novel insights into the skin's acute and chronic responses to UV in a lesion- and cell-type-specific manner.

scholarly journals Protective Effects of Salicornia europaea on UVB-Induced Misoriented Cell Divisions in Skin Epithelium

Cosmetics ◽  
2020 ◽  
Vol 7 (2) ◽  
pp. 44
Author(s):  
Natsumi Doi ◽  
Hiro Togari ◽  
Kenji Minagi ◽  
Koichi Nakaoji ◽  
Kazuhiko Hamada ◽  
...  
Keyword(s):  
Cell Division ◽  
Protective Effects ◽  
Salicornia Europaea ◽  
Basal Keratinocytes ◽  
Exposed Skin ◽  
Correct Orientation ◽  
Compensatory Proliferation ◽  
Skin Morphogenesis ◽  
Induced Changes

Correct orientation of cell division is extremely important in the maintenance, regeneration, and repair of continuously proliferating tissues, such as the epidermis. Regulation of the axis of division of epidermal cells prevents the apoptosis-induced compensatory proliferation, and eventually the cancer. Thus, the orientation of cell division is critical for maintaining the tissue architecture. In this study, we investigated the effects of S. europaea extract on the texture of human skin and the behavior of these cells during skin morphogenesis. In sun-exposed skin, S. europaea improved the texture. A multilayered, highly differentiated in vitro skin model indicated that, S. europaea extract suppressed the UVB-induced changes in the morphology of basal keratinocytes. Orientation of cell division was determined by measuring the axis of mitosis in the vertical sections of our experimental model. Analyses of the digital images revealed that S. europaea preserved the axis of division of basal keratinocytes from UVB-induced perturbations. Our findings uncover a new mechanism by which S. europaea responds to the spindle misorientation induced by UVB.

scholarly journals Ozone therapy promotes the differentiation of basal keratinocytes via increasing Tp63‐mediated transcription of KRT10 to improve psoriasis

2020 ◽  
Vol 24 (8) ◽  
pp. 4819-4829
Author(s):  
Lihua Gao ◽  
Jianhua Dou ◽  
Bo Zhang ◽  
Jinrong Zeng ◽  
Qingmei Cheng ◽  
...  
Keyword(s):  
Ozone Therapy ◽  
Basal Keratinocytes

scholarly journals Skin Retinoid Concentrations Are Modulated by CYP26AI Expression Restricted to Basal Keratinocytes in Normal Human Skin and Differentiated 3D Skin Models

2006 ◽  
Vol 126 (11) ◽  
pp. 2473-2480 ◽  
Author(s):  
Ruth Heise ◽  
Jörg Mey ◽  
Mark M. Neis ◽  
Yvonne Marquardt ◽  
Sylvia Joussen ◽  
...  
Keyword(s):  
Human Skin ◽  
Normal Human Skin ◽  
Basal Keratinocytes ◽  
Normal Human ◽  
3D Skin
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