scholarly journals Understanding morphogenesis in Drosophila oogenesis: Role of insulin signaling in border cell migration

2017 ◽  
Vol 145 ◽  
pp. S21
Author(s):  
Aditi Sharma ◽  
Mohit Prasad
Keyword(s):  
Cell Migration ◽  
Insulin Signaling ◽  
Drosophila Oogenesis ◽  
Border Cell ◽  
Border Cell Migration

scholarly journals Denise Montell: Lighting the way in border cell migration

2011 ◽  
Vol 195 (4) ◽  
pp. 540-541
Author(s):  
Caitlin Sedwick
Keyword(s):  
Cell Migration ◽  
Border Cells ◽  
Collective Migration ◽  
Drosophila Oogenesis ◽  
Border Cell ◽  
Border Cell Migration ◽  
The Way

Montell studies Drosophila oogenesis, focusing primarily on the collective migration of border cells.

New slbo-Gal4 driver lines for the analysis of border cell migration during Drosophila oogenesis

Chromosoma ◽  
2018 ◽  
Vol 127 (4) ◽  
pp. 475-487 ◽  
Author(s):  
Anna A. Ogienko ◽  
Lyubov A. Yarinich ◽  
Elena V. Fedorova ◽  
Mikhail O. Lebedev ◽  
Evgeniya N. Andreyeva ◽  
...  
Keyword(s):  
Cell Migration ◽  
Gal4 Driver ◽  
Drosophila Oogenesis ◽  
Border Cell ◽  
Border Cell Migration

scholarly journals The JAK/STAT pathway is required for border cell migration during Drosophila oogenesis

2002 ◽  
Vol 111 (1-2) ◽  
pp. 115-123 ◽  
Author(s):  
Simone Beccari ◽  
Luı́s Teixeira ◽  
Pernille Rørth
Keyword(s):  
Cell Migration ◽  
Drosophila Oogenesis ◽  
Border Cell ◽  
Border Cell Migration ◽  
Stat Pathway

scholarly journals On the Role of PDZ Domain-Encoding Genes in Drosophila Border Cell Migration

2012 ◽  
Vol 2 (11) ◽  
pp. 1379-1391 ◽  
Author(s):  
George Aranjuez ◽  
Elizabeth Kudlaty ◽  
Michelle S. Longworth ◽  
Jocelyn A. McDonald
Keyword(s):  
Cell Migration ◽  
Pdz Domain ◽  
Border Cell ◽  
Border Cell Migration ◽  
Encoding Genes

scholarly journals Fascin regulates protrusions and delamination to mediate invasive, collective cell migration in vivo

2019 ◽  
Author(s):  
Maureen C. Lamb ◽  
Kelsey K. Anliker ◽  
Tina L. Tootle
Keyword(s):  
Cell Migration ◽  
Cancer Metastasis ◽  
Collective Cell Migration ◽  
Nurse Cells ◽  
Border Cells ◽  
Border Cell ◽  
Migration Data ◽  
Border Cell Migration

AbstractFascin is an actin bundling protein that is essential for developmental cell migrations and promotes cancer metastasis. In addition to bundling actin, Fascin has several actin-independent roles. Border cell migration during Drosophila oogenesis provides an excellent model to study Fascin’s various roles during invasive, collective cell migration. Border cell migration requires Fascin. Fascin functions not only within the migrating border cells, but also within the nurse cells, the substrate for this migration. Loss of Fascin results in increased, shorter and mislocalized protrusions during migration. Data supports the model that Fascin promotes the activity of Enabled, an actin elongating factor, to regulate migration. Additionally, loss of Fascin inhibits border cell delamination. These defects are partially due to altered E-cadherin localization in the border cells; this is predicted to be an actin-independent role of Fascin. Overall, Fascin is essential for multiple aspects of this invasive, collective cell migration, and functions in both actin-dependent and -independent manners. These findings have implications beyond Drosophila, as border cell migration has emerged as a model to study mechanisms mediating cancer metastasis.

scholarly journals Hypoxia response pathway in border cell migration

2010 ◽  
Vol 4 (3) ◽  
pp. 391-395 ◽  
Author(s):  
Inna Djagaeva ◽  
Sergey Doronkin
Keyword(s):  
Cell Migration ◽  
Hypoxia Response ◽  
Border Cell ◽  
Border Cell Migration

The breathless FGF receptor homolog, a downstream target of Drosophila C/EBP in the developmental control of cell migration

Development ◽  
1995 ◽  
Vol 121 (8) ◽  
pp. 2255-2263 ◽  
Author(s):  
A.M. Murphy ◽  
T. Lee ◽  
C.M. Andrews ◽  
B.Z. Shilo ◽  
D.J. Montell
Keyword(s):  
Cell Migration ◽  
Molecular Mechanisms ◽  
Follicle Cells ◽  
Border Cells ◽  
Timely Initiation ◽  
Fgf Receptor ◽  
Border Cell ◽  
Downstream Target ◽  
Border Cell Migration ◽  
Factor C

To investigate the molecular mechanisms responsible for the temporal and spatial control of cell movements during development, we have been studying the migration of a small group of follicle cells, called the border cells, in the Drosophila ovary. Timely initiation of border cell migration requires the product of the slow border cells (slbo) locus, which encodes the Drosophila homolog of the transcription factor C/EBP. Here we report evidence that one target of C/EBP in the control of border cell migration is the FGF receptor homolog encoded by the breathless (btl) locus. btl expression in the ovary was border cell-specific, beginning just prior to the migration, and this expression was reduced in slbo mutants. btl mutations dominantly enhanced the border cell migration defects found in weak slbo alleles. Furthermore, C/EBP-independent btl expression was able to rescue the migration defects of hypomorphic slbo alleles. Purified Drosophila C/EBP bound eight sites in the btl 5′ flanking region by DNAse I footprinting. Taken together these results suggest that btl is a key, direct target for C/EBP in the regulation of border cell migration.

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