scholarly journals Non-Smad-Dependent BMP signaling Determines the size of Germline Stem Cell Pool via the Soma

2017 ◽  
Vol 145 ◽  
pp. S174
Author(s):  
Chen-Yuan Tseng ◽  
Yu-Han Su ◽  
Hwei-Jan Hsu
Keyword(s):  
Stem Cell ◽  
Bmp Signaling ◽  
Germline Stem Cell ◽  
Cell Pool ◽  
Stem Cell Pool

scholarly journals Smad-Independent BMP Signaling in Somatic Cells Limits the Size of the Germline Stem Cell Pool

2018 ◽  
Vol 11 (3) ◽  
pp. 811-827 ◽  
Author(s):  
Chen-Yuan Tseng ◽  
Yu-Han Su ◽  
Shun-Min Yang ◽  
Kun-Yang Lin ◽  
Chun-Ming Lai ◽  
...  
Keyword(s):  
Stem Cell ◽  
Somatic Cells ◽  
Bmp Signaling ◽  
Germline Stem Cell ◽  
Cell Pool ◽  
Stem Cell Pool

scholarly journals JNK signaling triggers spermatogonial dedifferentiation during chronic stress to maintain the germline stem cell pool in the Drosophila testis

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Salvador C Herrera ◽  
Erika A Bach
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Chronic Stress ◽  
Germline Stem Cell ◽  
Germline Stem Cells ◽  
Jnk Signaling ◽  
Cell Pool ◽  
Drosophila Testis ◽  
Bag Of Marbles ◽  
Stem Cell Pool

Exhaustion of stem cells is a hallmark of aging. In the Drosophila testis, dedifferentiated germline stem cells (GSCs) derived from spermatogonia increase during lifespan, leading to the model that dedifferentiation counteracts the decline of GSCs in aged males. To test this, we blocked dedifferentiation by mis-expressing the differentiation factor bag of marbles (bam) in spermatogonia while lineage-labeling these cells. Strikingly, blocking bam-lineage dedifferentiation under normal conditions in virgin males has no impact on the GSC pool. However, in mated males or challenging conditions, inhibiting bam-lineage dedifferentiation markedly reduces the number of GSCs and their ability to proliferate and differentiate. We find that bam-lineage derived GSCs have significantly higher proliferation rates than sibling GSCs in the same testis. We determined that Jun N-terminal kinase (JNK) activity is autonomously required for bam-lineage dedifferentiation. Overall, we show that dedifferentiation provides a mechanism to maintain the germline and ensure fertility under chronically stressful conditions.

scholarly journals Aging germline stem cells in C. elegans

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 740-740
Author(s):  
E Jane Hubbard
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell System ◽  
Cell Aging ◽  
Germline Stem Cell ◽  
Germline Stem Cells ◽  
C Elegans ◽  
Cell Pool ◽  
Stem Cell System ◽  
Stem Cell Pool

Abstract Failure to maintain stem cells with age is associated with conditions such as tissue degeneration and increased susceptibility to tissue damage. We use the C. elegans germline stem cell system as a model to study stem cell aging. This system combines a well-established model for aging with an accessible stem cell system, providing a unique opportunity to understand how aging influences stem cell dynamics. The germline stem/progenitor pool in in C. elegans becomes depleted over time. At the cellular level, aging influences both the size of the stem cell pool and the proliferation rate of stem cells. The flux of differentiated cells also affects how aging impacts the pool. This depletion is partially alleviated in mutants with reduced insulin/IGF-like signaling via inhibition of the transcription factor DAF-16/FOXO. In this role, DAF-16 does not act in the germ line, and its anatomical requirements are different from its previously described roles in larval germline proliferation, dauer control, and lifespan regulation. We found that DAF-16/FOXO is required in certain somatic cells in the proximal part of the reproductive system to regulate the stem cell pool. We also find that the degree to which various age-defying perturbations affect lifespan does not correlate with their effect on germline stem cell maintenance. We are investigating additional aspects of aging germline stem cells using this system.

Analysis of the C. elegans Germline Stem Cell Pool

2016 ◽  
pp. 1-33 ◽  
Author(s):  
Sarah L. Crittenden ◽  
Hannah S. Seidel ◽  
Judith Kimble
Keyword(s):  
Stem Cell ◽  
Germline Stem Cell ◽  
C Elegans ◽  
Cell Pool ◽  
Stem Cell Pool

scholarly journals A DTC Niche Plexus Surrounds the Germline Stem Cell Pool in Caenorhabditis elegans

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88372 ◽  
Author(s):  
Dana T. Byrd ◽  
Karla Knobel ◽  
Katharyn Affeldt ◽  
Sarah L. Crittenden ◽  
Judith Kimble
Keyword(s):  
Stem Cell ◽  
Caenorhabditis Elegans ◽  
Germline Stem Cell ◽  
Cell Pool ◽  
Stem Cell Pool
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