scholarly journals Regulation of the adult muscle stem cell niche by Notch and extracellular matrix signalling

2017 ◽  
Vol 145 ◽  
pp. S173
Author(s):  
Meryem Baghdadi ◽  
David Castel ◽  
So-ichiro Fukada ◽  
David Birk ◽  
Frederic Relaix ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Muscle Stem Cell ◽  
Adult Muscle ◽  
Cell Niche

scholarly journals Extracellular matrix and the neural stem cell niche

2011 ◽  
Vol 71 (11) ◽  
pp. 1006-1017 ◽  
Author(s):  
Ilias Kazanis ◽  
Charles ffrench-Constant
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Stem Cell Niche ◽  
Neural Stem Cell Niche ◽  
Cell Niche

The Muscle Stem Cell Niche in Health and Disease

2018 ◽  
pp. 23-65 ◽  
Author(s):  
Omid Mashinchian ◽  
Addolorata Pisconti ◽  
Emmeran Le Moal ◽  
C. Florian Bentzinger
Keyword(s):  
Stem Cell ◽  
Stem Cell Niche ◽  
Muscle Stem Cell ◽  
Health And Disease ◽  
Cell Niche

scholarly journals Telocytes within human skeletal muscle stem cell niche

2011 ◽  
Vol 15 (10) ◽  
pp. 2269-2272 ◽  
Author(s):  
Florina M. Bojin ◽  
Oana I. Gavriliuc ◽  
Mirabela I. Cristea ◽  
Gabriela Tanasie ◽  
Carmen S. Tatu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Human Skeletal Muscle ◽  
Muscle Stem Cell ◽  
Cell Niche

scholarly journals Visualization of the Skeletal Muscle Stem Cell Niche in Fiber Bundles

2021 ◽  
Vol 1 (10) ◽  
Author(s):  
Svenja C. Schüler ◽  
Simon Dumontier ◽  
Jonathan Rigaux ◽  
C. Florian Bentzinger
Keyword(s):  
Skeletal Muscle ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Fiber Bundles ◽  
Muscle Stem Cell ◽  
Cell Niche

scholarly journals Fractone bulbs derive from ependymal cells and their laminin composition influence the stem cell niche in the subventricular zone

2016 ◽  
Author(s):  
Marcos Assis Nascimento ◽  
Lydia Sorokin ◽  
Tatiana Coelho-Sampaio
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Stem Cell ◽  
Neural Stem Cells ◽  
Neural Stem Cell ◽  
Adult Neurogenesis ◽  
Subventricular Zone ◽  
Stem Cell Niche ◽  
Ependymal Cells ◽  
Cell Niche

AbstractFractones are extracellular matrix structures in the neural stem cell niche of the subventricular zone (SVZ), where they appear as round deposits named bulbs or thin branching lines called stems. Their cellular origin and what determines their localization at this site is poorly studied and it remains unclear whether they influence neural stem and progenitor cells formation, proliferation and/or maintenance. To address these questions, we analyzed whole mount preparations of the lateral ventricle by confocal microscopy using different extracellular matrix and cell markers. We found that bulbs are rarely connected to stems and that they contain laminin α5 and α2 chains, respectively. Fractone bulbs were profusely distributed throughout the SVZ and appeared associated with the center of pinwheels, a critical site for adult neurogenesis. We demonstrate that bulbs appear at the apical membrane of ependymal cells at the end of the first week after birth. The use of transgenic mice lacking laminin α5 gene expression (Lama5) in endothelium and in FoxJ1-expressing ependymal cells, revealed ependymal cells as the source of laminin α5-containing fractone bulbs. Loss of laminin α5 from bulbs correlated with a 60% increase in cell proliferation, as determined by PH3 staining, and with a selective reduction in the number of quiescent neural stem cells in the SVZ. These results indicate that fractones are a key component of the SVZ and suggest that laminin α5 modulates the physiology of the neural stem cell niche.Significance StatementOur work unveils key aspects of fractones, extracellular matrix structures present in the SVZ that still lack a comprehensive characterization. We show that fractones extensively interact with neural stem cells, whereas some of them are located precisely at pinwheel centers, which are hotspots for adult neurogenesis. Our results also demonstrate that fractones increase in size during aging and that their interactions with NSPCs become more complex in old mice. Lastly, we show that fractone bulbs are produced by ependymal cells and that their laminin content regulates neural stem cells.

Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche

2012 ◽  
Vol 24 (5) ◽  
pp. 645-651 ◽  
Author(s):  
Maria Felice Brizzi ◽  
Guido Tarone ◽  
Paola Defilippi
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Growth Factors ◽  
Stem Cell Niche ◽  
Cell Niche
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