scholarly journals Importin α1 is required for maintaining germline stem cells in Drosophila melanogaster testes

2017 ◽  
Vol 145 ◽  
pp. S163-S164
Author(s):  
James Heaney ◽  
Franca Casagranda ◽  
Gary Hime
Keyword(s):  
Stem Cells ◽  
Drosophila Melanogaster ◽  
Germline Stem Cells

scholarly journals Endocrine regulation of female germline stem cells in the fruit fly Drosophila melanogaster

2019 ◽  
Vol 31 ◽  
pp. 14-19 ◽  
Author(s):  
Yuto Yoshinari ◽  
Yoshitomo Kurogi ◽  
Tomotsune Ameku ◽  
Ryusuke Niwa
Keyword(s):  
Stem Cells ◽  
Drosophila Melanogaster ◽  
Fruit Fly ◽  
Endocrine Regulation ◽  
Germline Stem Cells ◽  
Female Germline

The germline stem cells of Drosophila melanogaster partition DNA non-randomly

2009 ◽  
Vol 88 (7) ◽  
pp. 397-408 ◽  
Author(s):  
Phillip Karpowicz ◽  
Milena Pellikka ◽  
Evelyn Chea ◽  
Dorothea Godt ◽  
Ulrich Tepass ◽  
...  
Keyword(s):  
Stem Cells ◽  
Drosophila Melanogaster ◽  
Germline Stem Cells

scholarly journals Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster

2021 ◽  
Vol 12 ◽  
Author(s):  
Ryo Hoshino ◽  
Ryusuke Niwa
Keyword(s):  
Stem Cells ◽  
Drosophila Melanogaster ◽  
Energy Demand ◽  
Seminal Fluid ◽  
Fruit Fly ◽  
Egg Laying ◽  
Germline Stem Cells ◽  
Humoral Factors ◽  
Mating Response ◽  
Sex Peptide

In many insect species, mating stimuli can lead to changes in various behavioral and physiological responses, including feeding, mating refusal, egg-laying behavior, energy demand, and organ remodeling, which are collectively known as the post-mating response. Recently, an increase in germline stem cells (GSCs) has been identified as a new post-mating response in both males and females of the fruit fly, Drosophila melanogaster. We have extensively studied mating-induced increase in female GSCs of D. melanogaster at the molecular, cellular, and systemic levels. After mating, the male seminal fluid peptide [e.g. sex peptide (SP)] is transferred to the female uterus. This is followed by binding to the sex peptide receptor (SPR), which evokes post-mating responses, including increase in number of female GSCs. Downstream of SP-SPR signaling, the following three hormones and neurotransmitters have been found to act on female GSC niche cells to regulate mating-induced increase in female GSCs: (1) neuropeptide F, a peptide hormone produced in enteroendocrine cells; (2) octopamine, a monoaminergic neurotransmitter synthesized in ovary-projecting neurons; and (3) ecdysone, a steroid hormone produced in ovarian follicular cells. These humoral factors are secreted from each organ and are received by ovarian somatic cells and regulate the strength of niche signaling in female GSCs. This review provides an overview of the latest findings on the inter-organ relationship to regulate mating-induced female GSC increase in D. melanogaster as a model. We also discuss the remaining issues that should be addressed in the future.

scholarly journals Ballchen is required for self-renewal of germline stem cells in Drosophila melanogaster

Biology Open ◽  
2014 ◽  
Vol 3 (6) ◽  
pp. 510-521 ◽  
Author(s):  
B. Herzig ◽  
T. A. Yakulov ◽  
K. Klinge ◽  
U. Gunesdogan ◽  
H. Jackle ◽  
...  
Keyword(s):  
Stem Cells ◽  
Drosophila Melanogaster ◽  
Germline Stem Cells ◽  
Self Renewal

scholarly journals The impact of genetic background and gender on the increase in mitotic index in response to mating of Drosophila melanogaster

2020 ◽  
Author(s):  
Manashree Malpe ◽  
Cordula Schulz
Keyword(s):  
Stem Cells ◽  
Drosophila Melanogaster ◽  
Stem Cell ◽  
Mitotic Activity ◽  
Genetic Background ◽  
Control Specimen ◽  
Germline Stem Cells ◽  
And Gender ◽  
And Control ◽  
The Impact

SUMMARYThe replenishment of specialized cells depends on the activity of stem cells. Recent advances in stem cell research have shown that the germline stem cells (GSCs) in Drosophila melanogaster can increase their mitotic activity in response to mating. Here, we show that this ability to respond to mating is eliminated if the males are mutant for the ABC transporter, White, the genetic background for a plethora of fly lines. Furthermore, we were not able to reproduce previous findings that female flies increase their GSC numbers and mitotic activity upon mating. Our findings underline the importance of careful experimental design and control specimen.

scholarly journals Adaptive Evolution of Genes Involved in the Regulation of Germline Stem Cells in Drosophila melanogaster and D. simulans

2015 ◽  
Vol 5 (4) ◽  
pp. 583-592 ◽  
Author(s):  
Heather A. Flores ◽  
Vanessa L. Bauer DuMont ◽  
Aalya Fatoo ◽  
Diana Hubbard ◽  
Mohammed Hijji ◽  
...  
Keyword(s):  
Stem Cells ◽  
Drosophila Melanogaster ◽  
Adaptive Evolution ◽  
Germline Stem Cells

The shut-down Gene of Drosophila melanogaster Encodes a Novel FK506-Binding Protein Essential for the Formation of Germline Cysts During Oogenesis

Genetics ◽  
2000 ◽  
Vol 156 (1) ◽  
pp. 245-256
Author(s):  
Kirsteen Munn ◽  
Ruth Steward
Keyword(s):  
Stem Cells ◽  
Drosophila Melanogaster ◽  
Stem Cell ◽  
Positional Cloning ◽  
Binding Protein ◽  
Protein Domain ◽  
Germline Stem Cell ◽  
Germline Stem Cells ◽  
Fk506 Binding Protein ◽  
Cell Divisions

Abstract In Drosophila melanogaster, the process of oogenesis is initiated with the asymmetric division of a germline stem cell. This division results in the self-renewal of the stem cell and the generation of a daughter cell that undergoes four successive mitotic divisions to produce a germline cyst of 16 cells. Here, we show that shut-down is essential for the normal function of the germline stem cells. Analysis of weak loss-of-function alleles confirms that shut-down is also required at later stages of oogenesis. Clonal analysis indicates that shut-down functions autonomously in the germline. Using a positional cloning approach, we have isolated the shut-down gene. Consistent with its function, the RNA and protein are strongly expressed in the germline stem cells and in 16-cell cysts. The RNA is also present in the germ cells throughout embryogenesis. shut-down encodes a novel Drosophila protein similar to the heat-shock protein-binding immunophilins. Like immunophilins, Shut-down contains an FK506-binding protein domain and a tetratricopeptide repeat. In plants, high-molecular-weight immunophilins have been shown to regulate cell divisions in the root meristem in response to extracellular signals. Our results suggest that shut-down may regulate germ cell divisions in the germarium.

Sign in / Sign up

Export Citation Format

Share Document