scholarly journals Wnt/B-catenin signalling facilitates cell fate decision making in the early mouse embryo

2017 ◽  
Vol 145 ◽  
pp. S159 ◽  
Author(s):  
Elena Corujo-Simon ◽  
Joaquin Lilao-Garzon ◽  
Silvia Muñoz-Descalzo
Keyword(s):  
Decision Making ◽  
Cell Fate ◽  
Mouse Embryo ◽  
Cell Fate Decision ◽  
Early Mouse Embryo ◽  
Fate Decision ◽  
Early Mouse

LncRNAs and paraspeckles predict cell fate in early mouse embryo†

2019 ◽  
Vol 100 (5) ◽  
pp. 1129-1131
Author(s):  
Ying Zhang ◽  
Enkui Duan
Keyword(s):  
Cell Fate ◽  
Mouse Embryo ◽  
Early Mouse Embryo ◽  
Early Mouse

scholarly journals Anatomy of a blastocyst: Cell behaviors driving cell fate choice and morphogenesis in the early mouse embryo

genesis ◽  
2013 ◽  
Vol 51 (4) ◽  
pp. 219-233 ◽  
Author(s):  
Nadine Schrode ◽  
Panagiotis Xenopoulos ◽  
Anna Piliszek ◽  
Stephen Frankenberg ◽  
Berenika Plusa ◽  
...  
Keyword(s):  
Cell Fate ◽  
Mouse Embryo ◽  
Early Mouse Embryo ◽  
Cell Behaviors ◽  
Early Mouse

scholarly journals A hydraulic instability drives the cell death decision in the nematode germline

2020 ◽  
Author(s):  
N. T. Chartier ◽  
A. Mukherjee ◽  
J. Pfanzelter ◽  
S. Fürthauer ◽  
B. T. Larson ◽  
...  
Keyword(s):  
Decision Making ◽  
Cell Death ◽  
Cell Fate ◽  
Germ Cells ◽  
Cell Fate Decision ◽  
Homogeneous Population ◽  
C Elegans ◽  
The Common ◽  
Fate Decision ◽  
Cell Volumes

AbstractOocytes are large and resourceful. During oogenesis some germ cells grow, typically at the expense of others that undergo apoptosis. How germ cells are selected to live or die out of a homogeneous population remains unclear. Here we show that this cell fate decision in C. elegans is mechanical and related to tissue hydraulics. Germ cells become inflated when the pressure inside them is lower than in the common cytoplasmic pool. This condition triggers a hydraulic instability which amplifies volume differences and causes some germ cells to grow and others to shrink. Shrinking germ cells are extruded and die, as we demonstrate by reducing germ cell volumes via thermoviscous pumping. Together, this reveals a robust mechanism of mechanochemical cell fate decision making in the germline.

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