scholarly journals Charting cell migration dynamics during lateral plate mesoderm patterning in zebrafish using lightsheet microscopy

2017 ◽  
Vol 145 ◽  
pp. S79-S80
Author(s):  
Karin Dorien Prummel ◽  
Christopher Hess ◽  
Eline Brombacher ◽  
Anastasia Felker ◽  
Christian Mosimann
Keyword(s):  
Cell Migration ◽  
Lateral Plate Mesoderm ◽  
Lateral Plate ◽  
Migration Dynamics ◽  
Mesoderm Patterning

scholarly journals In vivo MRI of neural cell migration dynamics in the mouse brain

NeuroImage ◽  
2010 ◽  
Vol 50 (2) ◽  
pp. 456-464 ◽  
Author(s):  
Brian J. Nieman ◽  
Jeffrey Y. Shyu ◽  
Joe J. Rodriguez ◽  
A. Denise Garcia ◽  
Alexandra L. Joyner ◽  
...  
Keyword(s):  
Cell Migration ◽  
Mouse Brain ◽  
Neural Cell ◽  
Migration Dynamics

scholarly journals FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors

2018 ◽  
Vol 10 (1) ◽  
pp. 87-100 ◽  
Author(s):  
Charles Yoon ◽  
Hannah Song ◽  
Ting Yin ◽  
Damaris Bausch-Fluck ◽  
Andreas P. Frei ◽  
...  
Keyword(s):  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Lateral Plate Mesoderm ◽  
Lateral Plate ◽  
Cardiac Progenitors

scholarly journals Loss of Abdominal Muscle in Pitx2 Mutants Associated with Altered Axial Specification of Lateral Plate Mesoderm

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e42228 ◽  
Author(s):  
Diana Eng ◽  
Hsiao-Yen Ma ◽  
Jun Xu ◽  
Hung-Ping Shih ◽  
Michael K. Gross ◽  
...  
Keyword(s):  
Abdominal Muscle ◽  
Lateral Plate Mesoderm ◽  
Lateral Plate ◽  
Axial Specification

scholarly journals Antagonistic interactions in the zebrafish midline prior to the emergence of asymmetric gene expression are important for left–right patterning

2016 ◽  
Vol 371 (1710) ◽  
pp. 20150402 ◽  
Author(s):  
Rebecca D. Burdine ◽  
Daniel T. Grimes
Keyword(s):  
Gene Expression ◽  
Lateral Plate Mesoderm ◽  
Internal Organs ◽  
Lateral Plate ◽  
Left Right Asymmetry ◽  
Antagonistic Interactions

Left–right (L-R) asymmetry of the internal organs of vertebrates is presaged by domains of asymmetric gene expression in the lateral plate mesoderm (LPM) during somitogenesis. Ciliated L-R coordinators (LRCs) are critical for biasing the initiation of asymmetrically expressed genes, such as nodal and pitx2 , to the left LPM. Other midline structures, including the notochord and floorplate, are then required to maintain these asymmetries. Here we report an unexpected role for the zebrafish EGF-CFC gene one-eyed pinhead ( oep ) in the midline to promote pitx2 expression in the LPM. Late zygotic oep (LZ oep ) mutants have strongly reduced or absent pitx2 expression in the LPM, but this expression can be rescued to strong levels by restoring oep in midline structures only. Furthermore, removing midline structures from LZ oep embryos can rescue pitx2 expression in the LPM, suggesting the midline is a source of an LPM pitx2 repressor that is itself inhibited by oep . Reducing lefty1 activity in LZ oep embryos mimics removal of the midline, implicating lefty1 in the midline-derived repression. Together, this suggests a model where Oep in the midline functions to overcome a midline-derived repressor, involving lefty1 , to allow for the expression of left side-specific genes in the LPM. This article is part of the themed issue ‘Provocative questions in left–right asymmetry’.

scholarly journals Primary cilium polarity: morphogenetic consequences.

2018 ◽  
Author(s):  
Marco Regolini
Keyword(s):  
Primary Cilia ◽  
Break Symmetry ◽  
Otic Vesicle ◽  
Nodal Signaling ◽  
Lateral Plate Mesoderm ◽  
Cell Orientation ◽  
Lateral Plate ◽  
Situs Solitus ◽  
Left And Right ◽  
Breaking Symmetry

In zebrafish inner ear, hair cell orientation in anterior and posterior maculae of the embryonic otic vesicle is different (about 30-40 degrees): this is rather unusual in planar polarity mechanism of action, instead suggests that kinocilia may be rotationally polarized. In mice node, the innermost monociliated cells generate a left-ward fluid flow sensed by the immotile primary cilia of Left peri-nodal cells: the Nodal signaling pathway is then expressed asymmetrically, in the Left lateral plate mesoderm, breaking symmetry in visceral organs (situs solitus); however, Right peri-nodal cells also, if artificially excited by a right-ward flow, break symmetry and activate the Nodal cascade, though inverting visceral organ asymmetry (situs inversus); surprisingly, peri-nodal cells prove to be adept at distinguishing flow directionality. Recently, in the Kupffer vesicle (the zebrafish laterality organ), chiral primary cilia orientation has been described: primary cilia, in the left and right side, are symmetrically oriented, showing a mirror average divergence of about 15-20 degrees from the midline. This finding, taken together with the mirror behavior of mouse perinodal cells and zebrafish hair cells, champions the idea of primary cilia enantiomerism.

scholarly journals CelltrackR: an R package for fast and flexible analysis of immune cell migration data

2019 ◽  
Author(s):  
Inge M. N. Wortel ◽  
Katharina Dannenberg ◽  
Jeffrey C. Berry ◽  
Mark J. Miller ◽  
Johannes Textor
Keyword(s):  
Cell Migration ◽  
Immune Cell ◽  
Time Lapse ◽  
R Package ◽  
Management Quality ◽  
Analysis Methods ◽  
Migration Dynamics ◽  
Immune Cell Migration ◽  
Imaging Artifacts ◽  
Track Analysis

AbstractSummaryVisualization of cell migration via time-lapse microscopy has greatly advanced our understanding of the immune system. However, subtle differences in migration dynamics are easily obscured by biases and imaging artifacts. While several analysis methods have been suggested to address these issues, an integrated tool implementing them is currently lacking. Here, we present CelltrackR, an R package containing a diverse set of state-of-the-art analysis methods for (immune) cell tracks. CelltrackR supports the complete pipeline for track analysis by providing methods for data management, quality control, extracting and visualizing migration statistics, clustering tracks, and simulating cell migration.Availability and ImplementationCelltrackR is an open-source package released under the GPL-2 license, and is freely available on GitHub at https://github.com/ingewortel/[email protected], [email protected]

scholarly journals The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature

Development ◽  
2010 ◽  
Vol 137 (17) ◽  
pp. 2961-2971 ◽  
Author(s):  
S. Theis ◽  
K. Patel ◽  
P. Valasek ◽  
A. Otto ◽  
Q. Pu ◽  
...  
Keyword(s):  
Lateral Plate Mesoderm ◽  
Lateral Plate ◽  
Neck Musculature
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