scholarly journals Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system

2010 ◽  
Vol 127 (1-2) ◽  
pp. 137-145 ◽  
Author(s):  
Ramakrishnan Kannan ◽  
Christian Berger ◽  
Sudharani Myneni ◽  
Gerhard M. Technau ◽  
L.S. Shashidhara
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Fate ◽  
Cyclin E ◽  
Cell Fate Specification ◽  
Fate Specification

Ectopic expression of either the Drosophila gooseberry-distal or proximal gene causes alterations of cell fate in the epidermis and central nervous system

Development ◽  
1994 ◽  
Vol 120 (5) ◽  
pp. 1151-1161 ◽  
Author(s):  
Y. Zhang ◽  
A. Ungar ◽  
C. Fresquez ◽  
R. Holmgren
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Fate ◽  
Ectopic Expression ◽  
Cell Fate Specification ◽  
Single Function ◽  
Independent Functions ◽  
Segment Polarity ◽  
The Central Nervous System ◽  
The Common

Previous studies have shown that the segment polarity locus gooseberry, which contains two closely related transcripts gooseberry-proximal and gooseberry-distal, is required for proper development in both the epidermis and the central nervous system of Drosophila. In this study, the roles of the gooseberry proteins in the process of cell fate specification have been examined by generating two fly lines in which either gooseberry-distal or gooseberry-proximal expression is under the control of an hsp70 promoter. We have found that ectopic expression of either gooseberry protein causes cell fate transformations that are reciprocal to those of a gooseberry deletion mutant. Our results suggest that the gooseberry-distal protein is required for the specification of naked cuticle in the epidermis and specific neuroblasts in the central nervous system. These roles may reflect independent functions in neuroblasts and epidermal cells or a single function in the common ectodermal precursor cells. The gooseberry-proximal protein is also found in the same neuroblasts as gooseberry-distal and in the descendants of these cells.

scholarly journals Drosophila Embryonic CNS Development: Neurogenesis, Gliogenesis, Cell Fate, and Differentiation

Genetics ◽  
2019 ◽  
Vol 213 (4) ◽  
pp. 1111-1144 ◽  
Author(s):  
Stephen T. Crews
Keyword(s):  
Nervous System ◽  
Cell Fate ◽  
Molecular Genetic ◽  
Cell Fate Specification ◽  
Cns Development ◽  
Fate Specification ◽  
The Past ◽  
New Concepts ◽  
Embryonic Cns ◽  
Complex Organ

The Drosophila embryonic central nervous system (CNS) is a complex organ consisting of ∼15,000 neurons and glia that is generated in ∼1 day of development. For the past 40 years, Drosophila developmental neuroscientists have described each step of CNS development in precise molecular genetic detail. This has led to an understanding of how an intricate nervous system emerges from a single cell. These studies have also provided important, new concepts in developmental biology, and provided an essential model for understanding similar processes in other organisms. In this article, the key genes that guide Drosophila CNS development and how they function is reviewed. Features of CNS development covered in this review are neurogenesis, gliogenesis, cell fate specification, and differentiation.

A critical role for Cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster

2004 ◽  
Vol 7 (1) ◽  
pp. 56-62 ◽  
Author(s):  
Christian Berger ◽  
S. K. Pallavi ◽  
Mohit Prasad ◽  
L. S. Shashidhara ◽  
Gerhard M. Technau
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drosophila Melanogaster ◽  
Cell Fate ◽  
Cyclin E ◽  
Critical Role ◽  
Cell Fate Determination ◽  
Fate Determination ◽  
The Central Nervous System

scholarly journals Cyclin E Acts under the Control of Hox-Genes as a Cell Fate Determinant in the Developing Central Nervous System

Cell Cycle ◽  
2005 ◽  
Vol 4 (3) ◽  
pp. 422-425 ◽  
Author(s):  
Christian Berger ◽  
S.K. Pallavi ◽  
Mohit Prasad ◽  
L.S. Shashidhara ◽  
Gerhard M. Technau
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Fate ◽  
Hox Genes ◽  
Cyclin E ◽  
Cell Fate Determinant ◽  
A Cell

scholarly journals cnd-1/NeuroD1 Functions with the Homeobox Gene ceh-5/Vax2 and Hox Gene ceh-13/labial To Specify Aspects of RME and DD Neuron Fate in Caenorhabditis elegans

2020 ◽  
Vol 10 (9) ◽  
pp. 3071-3085
Author(s):  
Wendy Aquino-Nunez ◽  
Zachery E Mielko ◽  
Trae Dunn ◽  
Elise M Santorella ◽  
Ciara Hosea ◽  
...  
Keyword(s):  
Nervous System ◽  
Transcription Factor ◽  
Caenorhabditis Elegans ◽  
Cell Fate ◽  
Neural Development ◽  
Nervous System Development ◽  
Cell Fate Specification ◽  
Hox Gene ◽  
Fate Specification

Abstract Identifying the mechanisms behind neuronal fate specification are key to understanding normal neural development in addition to neurodevelopmental disorders such as autism and schizophrenia. In vivo cell fate specification is difficult to study in vertebrates. However, the nematode Caenorhabditis elegans, with its invariant cell lineage and simple nervous system of 302 neurons, is an ideal organism to explore the earliest stages of neural development. We used a comparative transcriptome approach to examine the role of cnd-1/NeuroD1 in C. elegans nervous system development and function. This basic helix-loop-helix transcription factor is deeply conserved across phyla and plays a crucial role in cell fate specification in both the vertebrate nervous system and pancreas. We find that cnd-1 controls expression of ceh-5, a Vax2-like homeobox class transcription factor, in the RME head motorneurons and PVQ tail interneurons. We also show that cnd-1 functions redundantly with the Hox gene ceh-13/labial in defining the fate of DD1 and DD2 embryonic ventral nerve cord motorneurons. These data highlight the utility of comparative transcriptomes for identifying transcription factor targets and understanding gene regulatory networks.

Cell fate specification by even-skipped expression in the Drosophila nervous system is coupled to cell cycle progression

Development ◽  
1995 ◽  
Vol 121 (11) ◽  
pp. 3713-3721 ◽  
Author(s):  
K. Weigmann ◽  
C.F. Lehner
Keyword(s):  
Cell Cycle ◽  
Nervous System ◽  
Cell Fate ◽  
Mother Cell ◽  
Cell Cycle Progression ◽  
S Phase ◽  
Cell Fate Specification ◽  
Cycle Progression ◽  
Fate Specification ◽  
Ganglion Mother Cell

The correct specification of defined neurons in the Drosophila central nervous system is dependent on even-skipped. During CNS development, even-skipped expression starts in the ganglion mother cell resulting from the first asymmetric division of neuroblast NB 1–1. This first division of NB 1–1 (and of the other early neuroblasts as well) is temporally controlled by the transcriptional regulation of string expression, which we have manipulated experimentally, even-skipped expression still occurs if the first neuroblast division is delayed, but not if the division is prohibited. Moreover, even-skipped expression is also dependent on progression through S phase which follows immediately after the first division. However, cytokinesis during the first NB division is not required for even-skipped expression as revealed by observations in pebble mutant embryos. Our results demonstrate therefore that even-skipped expression is coupled to cell cycle progression, presumably in order to prevent a premature activation of expression by a positive regulator which is produced already in the neuroblast during G2 and segregated asymmetrically into the ganglion mother cell during mitosis.

scholarly journals Cell cycle independent role of Cyclin E during neural cell fate specification in Drosophila is mediated by its regulation of Prospero function

2010 ◽  
Vol 337 (2) ◽  
pp. 415-424 ◽  
Author(s):  
Christian Berger ◽  
Ramakrishnan Kannan ◽  
Sudharani Myneni ◽  
Simone Renner ◽  
L.S. Shashidhara ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Fate ◽  
Cyclin E ◽  
Neural Cell ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Neural Cell Fate
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