scholarly journals 13-P081 Distinct dynamics of Sonic Hedgehog signaling are required to specify floor plate and ventral neuronal identities in the vertebrate spinal cord

2009 ◽  
Vol 126 ◽  
pp. S219
Author(s):  
Vanessa Ribes ◽  
Nikolaos Balaskas ◽  
Noriaki Sasai ◽  
Eric Dessaud ◽  
Catarina Cruz ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Floor Plate ◽  
Sonic Hedgehog Signaling

Sonic hedgehog-dependent emergence of oligodendrocytes in the telencephalon: evidence for a source of oligodendrocytes in the olfactory bulb that is independent of PDGFRα signaling

Development ◽  
2001 ◽  
Vol 128 (24) ◽  
pp. 4993-5004
Author(s):  
Nathalie Spassky ◽  
Katharina Heydon ◽  
Arnaud Mangatal ◽  
Alexandar Jankovski ◽  
Christelle Olivier ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Olfactory Bulb ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Molecular Mechanisms ◽  
Cell Contact ◽  
Sonic Hedgehog Signaling ◽  
Oligodendrocyte Progenitors

Most studies on the origin of oligodendrocyte lineage have been performed in the spinal cord. By contrast, molecular mechanisms that regulate the appearance of the oligodendroglial lineage in the brain have not yet attracted much attention. We provide evidence for three distinct sources of oligodendrocytes in the mouse telencephalon. In addition to two subpallial ventricular foci, the anterior entopeduncular area and the medial ganglionic eminence, the rostral telencephalon also gives rise to oligodendrocytes. We show that oligodendrocytes in the olfactory bulb are generated within the rostral pallium from ventricular progenitors characterized by the expression of Plp. We provide evidence that these Plp oligodendrocyte progenitors do not depend on signal transduction mediated by platelet-derived growth factor receptors (PDGFRs), and therefore propose that they belong to a different lineage than the PDGFRα-expressing progenitors. Moreover, induction of oligodendrocytes in the telencephalon is dependent on sonic hedgehog signaling, as in the spinal cord. In all these telencephalic ventricular territories, oligodendrocyte progenitors were detected at about the same developmental stage as in the spinal cord. However, both in vivo and in vitro, the differentiation into O4-positive pre-oligodendrocytes was postponed by 4-5 days in the telencephalon in comparison with the spinal cord. This delay between determination and differentiation appears to be intrinsic to telencephalic oligodendrocytes, as it was not shortened by diffusible or cell-cell contact factors present in the spinal cord.

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice

Development ◽  
1998 ◽  
Vol 125 (14) ◽  
pp. 2533-2543 ◽  
Author(s):  
Q. Ding ◽  
J. Motoyama ◽  
S. Gasca ◽  
R. Mo ◽  
H. Sasaki ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Motor Neurons ◽  
Neural Tube ◽  
Hedgehog Signaling ◽  
Zinc Finger Protein ◽  
Floor Plate ◽  
Mutant Mice ◽  
Sonic Hedgehog Signaling ◽  
Cubitus Interruptus ◽  
High Level

Floor plate cells at the midline of the neural tube are specified by high-level activity of Sonic hedgehog (Shh) secreted by notochord, whereas motor neurons are thought to be specified by a lower level activity of Shh secreted in turn by floor plate cells. In Drosophila, the Gli zinc finger protein Cubitus interruptus functions as a transcription factor activating Hedgehog-responsive genes. We report that the expression of known Shh-responsive genes such as Ptc and Gli1 is downregulated in mutant mice lacking Gli2 function. Gli2 mutants fail to develop a floor plate yet still develop motor neurons, which occupy the ventral midline of the neural tube. Our results imply that Gli2 is required to mediate high level but not low level Shh activity and show that the development of motor neurons can occur in the absence of floor plate induction.

scholarly journals Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube

2010 ◽  
Vol 24 (11) ◽  
pp. 1186-1200 ◽  
Author(s):  
V. Ribes ◽  
N. Balaskas ◽  
N. Sasai ◽  
C. Cruz ◽  
E. Dessaud ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Neural Tube ◽  
Hedgehog Signaling ◽  
Floor Plate ◽  
Sonic Hedgehog Signaling ◽  
Neuronal Progenitors ◽  
Signaling Dynamics

scholarly journals Dynamics of Sonic hedgehog signaling in the ventral spinal cord are controlled by intrinsic changes in source cells requiring Sulfatase 1

Development ◽  
2014 ◽  
Vol 141 (6) ◽  
pp. 1392-1403 ◽  
Author(s):  
A. A. Oustah ◽  
C. Danesin ◽  
N. Khouri-Farah ◽  
M.-A. Farreny ◽  
N. Escalas ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
Sonic Hedgehog Signaling ◽  
Ventral Spinal Cord
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