scholarly journals 13-P063 Expression of Fibroblast growth factor 10 (Fgf10) in the developing mouse spinal cord is restricted to motor neurons

2009 ◽  
Vol 126 ◽  
pp. S213
Author(s):  
Niels Haan ◽  
Andrew Moore ◽  
Mohammad K Hajihosseini
Keyword(s):  
Spinal Cord ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Motor Neurons ◽  
Fibroblast Growth ◽  
Mouse Spinal Cord ◽  
Fibroblast Growth Factor 10

Motor neurons in human and rat spinal cord synthesize fibroblast growth factor-9

1997 ◽  
Vol 221 (2-3) ◽  
pp. 181-184 ◽  
Author(s):  
Satoshi Nakamura ◽  
Tomoki Todo ◽  
Seiichi Haga ◽  
Takako Aizawa ◽  
Yumiko Motoi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Motor Neurons ◽  
Fibroblast Growth ◽  
Rat Spinal Cord

scholarly journals Systemic Administration of Fibroblast Growth Factor 21 Improves the Recovery of Spinal Cord Injury (SCI) in Rats and Attenuates SCI-Induced Autophagy

2021 ◽  
Vol 11 ◽  
Author(s):  
Sipin Zhu ◽  
Yibo Ying ◽  
Lin Ye ◽  
Weiyang Ying ◽  
Jiahui Ye ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Functional Recovery ◽  
Nerve Cells ◽  
Systemic Administration ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Cord Injury

Protecting the death of nerve cells is an essential tactic for spinal cord injury (SCI) repair. Recent studies show that nerve growth factors can reduce the death of nerve cells and promote the healing of nerve injury. To investigate the conducive effect of fibroblast growth factor 21 (FGF21) on SCI repair. FGF21 proteins were systemically delivered into rat model of SCI via tail vein injection. We found that administration of FGF21 significantly promoted the functional recovery of SCI as assessed by BBB scale and inclined plane test, and attenuated cell death in the injured area by histopathological examination with Nissl staining. This was accompanied with increased expression of NeuN, GAP43 and NF200, and deceased expression of GFAP. Interestingly, FGF21 was found to attenuate the elevated expression level of the autophagy marker LC3-II (microtubules associated protein 1 light chain 3-II) induced by SCI in a dose-dependent manner. These data show that FGF21 promotes the functional recovery of SCI via restraining injury-induced cell autophagy, suggesting that systemic administration of FGF21 could have a therapeutic potential for SCI repair.

Increased Basic Fibroblast Growth Factor Expression Following Contusive Spinal Cord Injury

1996 ◽  
Vol 141 (1) ◽  
pp. 154-164 ◽  
Author(s):  
Italo Mocchetti ◽  
Stuart J. Rabin ◽  
Anna M. Colangelo ◽  
Scott R. Whittemore ◽  
Jean R. Wrathall
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Cord Injury ◽  
Factor Expression ◽  
Growth Factor Expression ◽  
Contusive Spinal Cord Injury

Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung

Development ◽  
1997 ◽  
Vol 124 (23) ◽  
pp. 4867-4878 ◽  
Author(s):  
S. Bellusci ◽  
J. Grindley ◽  
H. Emoto ◽  
N. Itoh ◽  
B.L. Hogan
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Lung Development ◽  
Expression Patterns ◽  
Branching Morphogenesis ◽  
Mouse Lung ◽  
Fibroblast Growth ◽  
Embryonic Mouse ◽  
Fibroblast Growth Factor 10

During mouse lung morphogenesis, the distal mesenchyme regulates the growth and branching of adjacent endoderm. We report here that fibroblast growth factor 10 (Fgf10) is expressed dynamically in the mesenchyme adjacent to the distal buds from the earliest stages of lung development. The temporal and spatial pattern of gene expression suggests that Fgf10 plays a role in directional outgrowth and possibly induction of epithelial buds, and that positive and negative regulators of Fgf10 are produced by the endoderm. In transgenic lungs overexpressing Shh in the endoderm, Fgf10 transcription is reduced, suggesting that high levels of SHH downregulate Fgf10. Addition of FGF10 to embryonic day 11.5 lung tissue (endoderm plus mesenchyme) in Matrigel or collagen gel culture elicits a cyst-like expansion of the endoderm after 24 hours. In Matrigel, but not collagen, this is followed by extensive budding after 48–60 hours. This response involves an increase in the rate of endodermal cell proliferation. The activity of FGF1, FGF7 and FGF10 was also tested directly on isolated endoderm in Matrigel culture. Under these conditions, FGF1 elicits immediate endodermal budding, while FGF7 and FGF10 initially induce expansion of the endoderm. However, within 24 hours, samples treated with FGF10 give rise to multiple buds, while FGF7-treated endoderm never progresses to bud formation, at all concentrations of factor tested. Although exogenous FGF1, FGF7 and FGF10 have overlapping activities in vitro, their in vivo expression patterns are quite distinct in relation to early branching events. We conclude that, during early lung development, localized sources of FGF10 in the mesoderm regulate endoderm proliferation and bud outgrowth.

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