scholarly journals 09-P019 The role of the non-canonical Wnt signalling pathway in branching morphogenesis

2009 ◽  
Vol 126 ◽  
pp. S156
Author(s):  
Laura L. Yates ◽  
Carsten Schnatwinkel ◽  
Jennifer N. Murdoch ◽  
Debora Bogani ◽  
Caroline J. Formstone ◽  
...  
Keyword(s):  
Branching Morphogenesis ◽  
Wnt Signalling ◽  
Signalling Pathway ◽  
Wnt Signalling Pathway ◽  
Canonical Wnt

scholarly journals Roles of Non-Canonical Wnt Signalling Pathways in Bone Biology

2021 ◽  
Vol 22 (19) ◽  
pp. 10840
Author(s):  
Jasna Lojk ◽  
Janja Marc
Keyword(s):  
Bone Tissue ◽  
Wnt Signalling ◽  
Signalling Pathway ◽  
Signalling Pathways ◽  
Bone Biology ◽  
Mineral Density ◽  
Wnt Signalling Pathway ◽  
Wnt Ligands ◽  
Canonical Wnt

The Wnt signalling pathway is one of the central signalling pathways in bone development, homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands, receptors and co-receptors, which ensure tight spatiotemporal regulation of Wnt signalling pathway activity and thus tight regulation of bone tissue homeostasis. This enables maintenance of optimal mineral density, tissue healing and adaptation to changes in bone loading. While the role of the canonical/β-catenin Wnt signalling pathway in bone homeostasis is relatively well researched, Wnt ligands can also activate several non-canonical, β-catenin independent signalling pathways with important effects on bone tissue. In this review, we will provide a thorough overview of the current knowledge on different non-canonical Wnt signalling pathways involved in bone biology, focusing especially on the pathways that affect bone cell differentiation, maturation and function, processes involved in bone tissue structure regulation. We will describe the role of the two most known non-canonical pathways (Wnt/planar cell polarity pathways and Wnt/Ca2+ pathway), as well as other signalling pathways with a strong role in bone biology that communicate with the Wnt signalling pathway through non-canonical Wnt signalling. Our goal is to bring additional attention to these still not well researched but important pathways in the regulation of bone biology in the hope of prompting additional research in the area of non-canonical Wnt signalling pathways.

Glucose induces an autocrine activation of the Wnt/β-catenin pathway in macrophage cell lines

2008 ◽  
Vol 416 (2) ◽  
pp. 211-218 ◽  
Author(s):  
Sasha H. Anagnostou ◽  
Peter R. Shepherd
Keyword(s):  
Cell Lines ◽  
Nuclear Translocation ◽  
Wnt Signalling ◽  
Signalling Pathway ◽  
Macrophage Cell ◽  
Glucose Levels ◽  
Wnt Signalling Pathway ◽  
Hexosamine Pathway ◽  
Number Of Genes ◽  
Canonical Wnt

The canonical Wnt signalling pathway acts by slowing the rate of ubiquitin-mediated β-catenin degradation. This results in the accumulation and subsequent nuclear translocation of β-catenin, which induces the expression of a number of genes involved in growth, differentiation and metabolism. The mechanisms regulating the Wnt signalling pathway in the physiological context is still not fully understood. In the present study we provide evidence that changes in glucose levels within the physiological range can acutely regulate the levels of β-catenin in two macrophage cell lines (J774.2 and RAW264.7 cells). In particular we find that glucose induces these effects by promoting an autocrine activation of Wnt signalling that is mediated by the hexosamine pathway and changes in N-linked glycosylation of proteins. These studies reveal that the Wnt/β-catenin system is a glucose-responsive signalling system and as such is likely to play a role in pathways involved in sensing changes in metabolic status.

Role of the Wnt Signalling Pathway in Cancer

2016 ◽  
pp. 1-8
Author(s):  
Rubin S Baskir ◽  
Amanda G Hansen ◽  
Ethan Lee
Keyword(s):  
Wnt Signalling ◽  
Signalling Pathway ◽  
Wnt Signalling Pathway

Wnt10b promotes growth of hair follicles via a canonical Wnt signalling pathway

2011 ◽  
Vol 36 (5) ◽  
pp. 534-540 ◽  
Author(s):  
Y.-H. Li ◽  
K. Zhang ◽  
J.-X. Ye ◽  
X.-H. Lian ◽  
T. Yang
Keyword(s):  
Hair Follicles ◽  
Wnt Signalling ◽  
Signalling Pathway ◽  
Wnt Signalling Pathway ◽  
Canonical Wnt
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