scholarly journals Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality

2008 ◽  
Vol 125 (5-6) ◽  
pp. 441-450 ◽  
Author(s):  
Yasunari Yamanaka ◽  
Toshio Heike ◽  
Tomohiro Kumada ◽  
Minoru Shibata ◽  
Yuki Takaoka ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Embryonic Lethality ◽  
Early Embryonic Lethality

scholarly journals Heterozygous loss of ZBTB38 leads to early embryonic lethality in mice via suppressing Nanog and Sox2

2021 ◽  
Author(s):  
Eishou Matsuda ◽  
Miki Nishio ◽  
Takuya Matsuura ◽  
Shunya Hibi ◽  
Shiomi Ohta ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cell Proliferation ◽  
Gene Expression Regulation ◽  
Epigenetic Modification ◽  
Embryonic Lethality ◽  
Biological Processes ◽  
Es Cell ◽  
Nanog Expression ◽  
Early Embryonic Lethality ◽  
Single Allele

Mammalian DNA methylation is an epigenetic modification which is involved in various biological processes, including gene expression regulation. In mice, methyltransferases are responsible for DNA methylation, which are critical for early embryogenesis. However, the significance of methyl-CpG binding proteins (MBPs) that bind methylated CpG remains largely unknown. We previously demonstrated that ZBTB38/CIBZ-a zinc finger type of MBP-is required for ES cell proliferation by positively regulating Nanog expression. However, the physiological function of ZBTB38 remains unclear. In this study, we generated conditional ZBTB38 knockout mice using Cre-loxP technology. Unexpectedly, our results showed that germline loss of the ZBTB38 single allele resulted in decreased epiblast cell proliferation and increased apoptosis shortly after implantation, leading to early embryonic lethality. We found that heterozygous loss of ZBTB38 reduced the expression of Nanog, Sox2, and the genes responsible for epiblast proliferation, differentiation, and cell viability. Despite this lethal phenotype, ZBTB38 is dispensable for ES cell establishment and identity. Together, these findings indicate that ZBTB38 is essential for early embryonic development, providing new insights into the roles of MBP in implantation.

scholarly journals p53 Accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101

2001 ◽  
Vol 98 (4) ◽  
pp. 1859-1864 ◽  
Author(s):  
J. Ruland ◽  
C. Sirard ◽  
A. Elia ◽  
D. MacPherson ◽  
A. Wakeham ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Embryonic Lethality ◽  
Early Embryonic Lethality

scholarly journals Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene

2010 ◽  
Vol 54 (8-9) ◽  
pp. 1259-1266 ◽  
Author(s):  
Pawel Grzmil ◽  
Zanabazar Enkhbaatar ◽  
Batjargal Gundsambuu ◽  
Odgerel Oidovsambuu ◽  
Safak Yalcin ◽  
...  
Keyword(s):  
Gene Trap ◽  
Embryonic Lethality ◽  
Early Embryonic Lethality

scholarly journals Targeted disruption of the mouse phospholipase C β3 gene results in early embryonic lethality

FEBS Letters ◽  
1998 ◽  
Vol 441 (2) ◽  
pp. 261-265 ◽  
Author(s):  
Shu Wang ◽  
Samuel Gebre-Medhin ◽  
Christer Betsholtz ◽  
Peter Stålberg ◽  
Yinghua Zhou ◽  
...  
Keyword(s):  
Phospholipase C ◽  
Embryonic Lethality ◽  
Targeted Disruption ◽  
Early Embryonic Lethality

scholarly journals Deregulated expression of ΔNp73α causes early embryonic lethality

2005 ◽  
Vol 13 (1) ◽  
pp. 170-173 ◽  
Author(s):  
S Erster ◽  
G Palacios ◽  
T Rosenquist ◽  
C Chang ◽  
U M Moll
Keyword(s):  
Embryonic Lethality ◽  
Early Embryonic Lethality
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