scholarly journals Evidence for a cooperative role of gelatinase A and membrane type-1 matrix metalloproteinase during Xenopus laevis development

2007 ◽  
Vol 124 (1) ◽  
pp. 11-22 ◽  
Author(s):  
Takashi Hasebe ◽  
Rebecca Hartman ◽  
Liezhen Fu ◽  
Tosikazu Amano ◽  
Yun-Bo Shi
Keyword(s):  
Xenopus Laevis ◽  
Matrix Metalloproteinase ◽  
Gelatinase A ◽  
Membrane Type

scholarly journals Piezo1 mediates angiogenesis through activation of MT1-MMP signaling

2019 ◽  
Vol 316 (1) ◽  
pp. C92-C103 ◽  
Author(s):  
Hojin Kang ◽  
Zhigang Hong ◽  
Ming Zhong ◽  
Jennifer Klomp ◽  
Kayla J. Bayless ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Sprouting Angiogenesis ◽  
Sphingosine 1 Phosphate ◽  
Wall Shear ◽  
Membrane Type

Angiogenesis is initiated in response to a variety of external cues, including mechanical and biochemical stimuli; however, the underlying signaling mechanisms remain unclear. Here, we investigated the proangiogenic role of the endothelial mechanosensor Piezo1. Genetic deletion and pharmacological inhibition of Piezo1 reduced endothelial sprouting and lumen formation induced by wall shear stress and proangiogenic mediator sphingosine 1-phosphate, whereas Piezo1 activation by selective Piezo1 activator Yoda1 enhanced sprouting angiogenesis. Similarly to wall shear stress, sphingosine 1-phosphate functioned by activating the Ca2+ gating function of Piezo1, which in turn signaled the activation of the matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase during sprouting angiogenesis. Studies in mice in which Piezo1 was conditionally deleted in endothelial cells demonstrated the requisite role of sphingosine 1-phosphate-dependent activation of Piezo1 in mediating angiogenesis in vivo. These results taken together suggest that both mechanical and biochemical stimuli trigger Piezo1-mediated Ca2+ influx and thereby activate matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase and synergistically facilitate sprouting angiogenesis.

Gelatinase A and Membrane-type 1 Matrix Metalloproteinase mRNA: Expressed in Adrenocortical Cancers but Not in Adenomas

1999 ◽  
Vol 23 (3) ◽  
pp. 237-242 ◽  
Author(s):  
Magnus Kjellman ◽  
Ulla Enberg ◽  
Anders Höög ◽  
Catharina Larsson ◽  
Mikael Holst ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Gelatinase A ◽  
Membrane Type

scholarly journals Cell surface binding and activation of gelatinase A induced by expression of membrane-type-1-matrix metalloproteinase (MT1-MMP)

FEBS Letters ◽  
1996 ◽  
Vol 385 (3) ◽  
pp. 238-240 ◽  
Author(s):  
Hiroshi Sato ◽  
Takahisa Takino ◽  
Takeshi Kinoshita ◽  
Kazushi Imai ◽  
Yasunori Okada ◽  
...  
Keyword(s):  
Cell Surface ◽  
Matrix Metalloproteinase ◽  
Gelatinase A ◽  
Surface Binding ◽  
Cell Surface Binding ◽  
Membrane Type

scholarly journals Conversion of Stationary to Invasive Tumor Initiating Cells (TICs): Role of Hypoxia in Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) Trafficking

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e38403 ◽  
Author(s):  
Jian Li ◽  
Stanley Zucker ◽  
Ashleigh Pulkoski-Gross ◽  
Cem Kuscu ◽  
Mihriban Karaayvaz ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Tumor Initiating Cells ◽  
Invasive Tumor ◽  
Membrane Type

scholarly journals Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis

Oncotarget ◽  
2016 ◽  
Vol 8 (2) ◽  
pp. 2781-2799 ◽  
Author(s):  
Albert G. Remacle ◽  
Piotr Cieplak ◽  
Dong Hyun Nam ◽  
Sergey A. Shiryaev ◽  
Xin Ge ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Human Antibody ◽  
Membrane Type

scholarly journals Membrane type 1 matrix metalloproteinase and gelatinase A synergistically degrade type 1 collagen in a cell model

FEBS Letters ◽  
2001 ◽  
Vol 491 (3) ◽  
pp. 222-226 ◽  
Author(s):  
Susan J. Atkinson ◽  
Margaret L. Patterson ◽  
Michael J. Butler ◽  
Gillian Murphy
Keyword(s):  
Matrix Metalloproteinase ◽  
Cell Model ◽  
Gelatinase A ◽  
A Cell ◽  
Membrane Type
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