scholarly journals emc has a role in dorsal appendage fate formation in Drosophila oogenesis

2005 ◽  
Vol 122 (9) ◽  
pp. 961-974 ◽  
Author(s):  
Sofia Papadia ◽  
George Tzolovsky ◽  
Debiao Zhao ◽  
Kevin Leaper ◽  
Dorothy Clyde ◽  
...  
Keyword(s):  
Drosophila Oogenesis ◽  
Dorsal Appendage

scholarly journals Cad74A is regulated by BR and is required for robust dorsal appendage formation in Drosophila oogenesis

2008 ◽  
Vol 322 (2) ◽  
pp. 289-301 ◽  
Author(s):  
Jeremiah J. Zartman ◽  
Nir Yakoby ◽  
Christopher A. Bristow ◽  
Xiaofeng Zhou ◽  
Karin Schlichting ◽  
...  
Keyword(s):  
Drosophila Oogenesis ◽  
Dorsal Appendage ◽  
Appendage Formation

scholarly journals A late phase of germ plasm accumulation during Drosophila oogenesis requires Lost and Rumpelstiltskin

Development ◽  
2011 ◽  
Vol 138 (16) ◽  
pp. 3431-3440 ◽  
Author(s):  
Kristina S. Sinsimer ◽  
Roshan A. Jain ◽  
Seema Chatterjee ◽  
Elizabeth R. Gavis
Keyword(s):  
Germ Plasm ◽  
Late Phase ◽  
Drosophila Oogenesis

fringeandNotchspecify polar cell fate duringDrosophilaoogenesis

Development ◽  
2001 ◽  
Vol 128 (12) ◽  
pp. 2243-2253 ◽  
Author(s):  
Muriel Grammont ◽  
Kenneth D. Irvine
Keyword(s):  
Cell Fate ◽  
Null Allele ◽  
Somatic Cells ◽  
Ectopic Expression ◽  
Notch Receptor ◽  
Drosophila Oogenesis ◽  
Early Stages ◽  
Polar Cell ◽  
Hypomorphic Alleles ◽  
Notch Activation

fringe encodes a glycosyltransferase that modulates the ability of the Notch receptor to be activated by its ligands. We describe studies of fringe function during early stages of Drosophila oogenesis. Animals mutant for hypomorphic alleles of fringe contain follicles with an incorrect number of germline cells, which are separated by abnormally long and disorganized stalks. Analysis of clones of somatic cells mutant for a null allele of fringe localizes the requirement for fringe in follicle formation to the polar cells, and demonstrates that fringe is required for polar cell fate. Clones of cells mutant for Notch also lack polar cells and the requirement for Notch in follicle formation appears to map to the polar cells. Ectopic expression of fringe or of an activated form of Notch can generate an extra polar cell. Our results indicate that fringe plays a key role in positioning Notch activation during early oogenesis, and establish a function for the polar cells in separating germline cysts into individual follicles.

scholarly journals Extracellular spreading of Wingless is required for Drosophila oogenesis

PLoS Genetics ◽  
2021 ◽  
Vol 17 (4) ◽  
pp. e1009469
Author(s):  
Xiaoxi Wang ◽  
Kimberly S. LaFever ◽  
Indrayani Waghmare ◽  
Andrea Page-McCaw
Keyword(s):  
Stem Cells ◽  
Wnt Signaling ◽  
Long Range ◽  
Wing Disc ◽  
Secreted Protein ◽  
Loss Of Function ◽  
Drosophila Oogenesis ◽  
Central Source ◽  
Follicle Stem Cells

Recent studies have investigated whether the Wnt family of extracellular ligands can signal at long range, spreading from their source and acting as morphogens, or whether they signal only in a juxtacrine manner to neighboring cells. The original evidence for long-range Wnt signaling arose from studies of Wg, a Drosophila Wnt protein, which patterns the wing disc over several cell diameters from a central source of Wg ligand. However, the requirement of long-range Wg for patterning was called into question when it was reported that replacing the secreted protein Wg with a membrane-tethered version, NRT-Wg, results in flies with normally patterned wings. We and others previously reported that Wg spreads in the ovary about 50 μm or 5 cell diameters, from the cap cells to the follicle stem cells (FSCs) and that Wg stimulates FSC proliferation. We used the NRT-wg flies to analyze the consequence of tethering Wg to the cap cells. NRT-wg homozygous flies are sickly, but we found that hemizygous NRT-wg/null flies, carrying only one copy of tethered Wingless, were significantly healthier. Despite their overall improved health, these hemizygous flies displayed dramatic reductions in fertility and in FSC proliferation. Further, FSC proliferation was nearly undetectable when the wg locus was converted to NRT-wg only in adults, and the resulting germarium phenotype was consistent with a previously reported wg loss-of-function phenotype. We conclude that Wg protein spreads from its source cells in the germarium to promote FSC proliferation.

scholarly journals A two-step Notch-dependant mechanism controls the selection of the polar cell pair in Drosophila oogenesis

Development ◽  
2010 ◽  
Vol 137 (16) ◽  
pp. 2703-2711 ◽  
Author(s):  
C. Vachias ◽  
J.-L. Couderc ◽  
M. Grammont
Keyword(s):  
Drosophila Oogenesis ◽  
Cell Pair ◽  
Polar Cell ◽  
Selection Of
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