scholarly journals Functional analysis of seven genes encoding eight translation initiation factor 4E (eIF4E) isoforms in Drosophila

2005 ◽  
Vol 122 (4) ◽  
pp. 529-543 ◽  
Author(s):  
Greco Hernández ◽  
Michael Altmann ◽  
José Manuel Sierra ◽  
Henning Urlaub ◽  
Ruth Diez del Corral ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Translation Initiation ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Genes Encoding

scholarly journals Crystal structure of the MIF4G domain of the Trypanosoma cruzi translation initiation factor EIF4G5

2019 ◽  
Vol 75 (12) ◽  
pp. 738-743
Author(s):  
Lucca Pietro Camillo dos Santos ◽  
Bruno Moisés de Matos ◽  
Brenda Cecilia de Maman Ribeiro ◽  
Nilson Ivo Tonin Zanchin ◽  
Beatriz Gomes Guimarães
Keyword(s):  
Crystal Structure ◽  
Translation Initiation ◽  
Specific Interaction ◽  
Three Dimensional ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Dimensional Structure ◽  
Initiation Factors ◽  
Genes Encoding ◽  
Rna Complexes

Kinetoplastida, a class of early-diverging eukaryotes that includes pathogenic Trypanosoma and Leishmania species, display key differences in their translation machinery compared with multicellular eukaryotes. One of these differences involves a larger number of genes encoding eIF4E and eIF4G homologs and the interaction pattern between the translation initiation factors. eIF4G is a scaffold protein which interacts with the mRNA cap-binding factor eIF4E, the poly(A)-binding protein, the RNA helicase eIF4A and the eIF3 complex. It contains the so-called middle domain of eIF4G (MIF4G), a multipurpose adaptor involved in different protein–protein and protein–RNA complexes. Here, the crystal structure of the MIF4G domain of T. cruzi EIF4G5 is described at 2.4 Å resolution, which is the first three-dimensional structure of a trypanosomatid MIF4G domain to be reported. Structural comparison with IF4G homologs from other eukaryotes and other MIF4G-containing proteins reveals differences that may account for the specific interaction mechanisms of MIF4G despite its highly conserved overall fold.

Functional analysis of homologs of translation initiation factor 2γ in yeast

1997 ◽  
Vol 253 (6) ◽  
pp. 711-719 ◽  
Author(s):  
F. L. Erickson ◽  
L. D. Harding ◽  
D. R. Dorris ◽  
E. M. Hannig
Keyword(s):  
Functional Analysis ◽  
Translation Initiation ◽  
Translation Initiation Factor ◽  
Initiation Factor
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