scholarly journals Myosin VI plays a role in cell–cell adhesion during epithelial morphogenesis

2004 ◽  
Vol 121 (11) ◽  
pp. 1335-1351 ◽  
Author(s):  
Hadas Millo ◽  
Kevin Leaper ◽  
Vasiliki Lazou ◽  
Mary Bownes
Keyword(s):  
Cell Adhesion ◽  
Epithelial Morphogenesis ◽  
Myosin Vi ◽  
Cell Cell

scholarly journals Epithelial Morphogenesis Driven by Cell-Matrix vs. Cell-Cell Adhesion

2020 ◽  
Author(s):  
Shaohe Wang ◽  
Kazue Matsumoto ◽  
Kenneth M. Yamada
Keyword(s):  
Cell Adhesion ◽  
Single Cell ◽  
Cell Sheet ◽  
Branching Morphogenesis ◽  
Epithelial Morphogenesis ◽  
Epithelial Surface ◽  
Matrix Adhesion ◽  
Cell Matrix ◽  
Cell Matrix Adhesion ◽  
Cell Cell

SUMMARYMany embryonic organs undergo epithelial morphogenesis to form tree-like hierarchical structures. However, it remains unclear what drives the budding and branching of stratified epithelia, such as in embryonic salivary gland and pancreas. Here, we performed live-organ imaging of mouse embryonic salivary glands at single-cell resolution to reveal that budding morphogenesis is driven by expansion and folding of a distinct epithelial surface cell sheet characterized by strong cell-matrix adhesions and weak cell-cell adhesions. Profiling of single-cell transcriptomes of this epithelium revealed spatial patterns of transcription underlying these cell adhesion differences. We then synthetically reconstituted budding morphogenesis by experimentally suppressing E-cadherin expression and inducing basement membrane formation in 3D spheroid cultures of engineered cells, which required β1 integrin-mediated cell-matrix adhesion for successful budding. Thus, stratified epithelial budding, the key first step of branching morphogenesis, is driven by an overall combination of strong cell-matrix adhesion and weak cell-cell adhesion by peripheral epithelial cells.

scholarly journals Heterophilic cell–cell adhesion of atypical cadherins Fat and Dachsous regulate epithelial cell size dynamics during Drosophila thorax morphogenesis

2020 ◽  
Vol 31 (7) ◽  
pp. 546-560
Author(s):  
Amit Kumar ◽  
Mohd Suhail Rizvi ◽  
Thamarailingam Athilingam ◽  
Saurabh Singh Parihar ◽  
Pradip Sinha
Keyword(s):  
Cell Adhesion ◽  
Epithelial Cell ◽  
Mathematical Simulation ◽  
Cell Size ◽  
Epithelial Morphogenesis ◽  
Dynamic Changes ◽  
Size Regulation ◽  
Genetic Techniques ◽  
Cell Cell

Epithelial morphogenesis is marked by dynamic changes in cell sizes until the final adult organ is formed. Using a combination of quantitative, mathematical simulation and genetic techniques, this paper reveals a novel mechanism of epithelial cell size regulation based on heterophilic cell–cell adhesion between two atypical cadherins, Ft and Ds.

scholarly journals Budding epithelial morphogenesis driven by cell-matrix versus cell-cell adhesion

Cell ◽  
2021 ◽  
Author(s):  
Shaohe Wang ◽  
Kazue Matsumoto ◽  
Samantha R. Lish ◽  
Alexander X. Cartagena-Rivera ◽  
Kenneth M. Yamada
Keyword(s):  
Cell Adhesion ◽  
Epithelial Morphogenesis ◽  
Matrix Versus ◽  
Cell Matrix ◽  
Cell Cell

622: Von Hippel-Lindau Inactivation Downregulates the Cell-Cell Adhesion Molecule E Cadherin in Renal Cancer Cells

2005 ◽  
Vol 173 (4S) ◽  
pp. 170-170
Author(s):  
Maxine G. Tran ◽  
Miguel A. Esteban ◽  
Peter D. Hill ◽  
Ashish Chandra ◽  
Tim S. O'Brien ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Cancer Cells ◽  
Renal Cancer ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Von Hippel Lindau ◽  
E Cadherin ◽  
Cell Cell
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