Influence of treatment-induced changes in tissue absorption on treatment volume during interstitial photodynamic therapy

2006 ◽  
Vol 21 (4) ◽  
pp. 261-270 ◽  
Author(s):  
Ann Johansson ◽  
Niels Bendsoe ◽  
Katarina Svanberg ◽  
Sune Svanberg ◽  
Stefan Andersson-Engels
Keyword(s):  
Photodynamic Therapy ◽  
Interstitial Photodynamic Therapy ◽  
Treatment Volume ◽  
Induced Changes

scholarly journals CTIM-16. INTERSTITIAL PHOTODYNAMIC THERAPY WITH 5-ALA FOR MALIGNANT GLIOMA RECURRENCES

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii36-ii36
Author(s):  
Stefanie Lietke ◽  
Michael Schmutzer ◽  
Christoph Schwartz ◽  
Jonathan Weller ◽  
Maximilian Aumiller ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Prognostic Factors ◽  
Malignant Glioma ◽  
Treatment Response ◽  
Risk Profile ◽  
Who Grade ◽  
Outcome Measurements ◽  
Interstitial Photodynamic Therapy ◽  
Treatment Volume ◽  
Permanent Morbidity

Abstract Interstitial photodynamic therapy (iPDT) using 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX (PPIX) as a cytotoxic photosensitizer has been shown to be a feasible treatment option for malignant gliomas. We present outcome measures and a risk profile analysis of salvage iPDT in a large monocentric cohort with local tumor recurrence following standard therapy. This study included consecutive adult patients undergoing salvage iPDT for small, circumscribed, biopsy-proven malignant glioma recurrences not deemed eligible for safe complete resection of contrast enhancing tumor. A modified 3-D treatment-planning software was used to calculate the treatment-volume and the position of the stereotactic light diffusers within the lesion. Outcome measurements included estimated time-to-treatment-failure (TTF), post-recurrence survival (PRS) and the risk profile of iPDT. Prognostic factors were obtained from logistic regression models. The institutional review board approved the study. A total of 44 patients (median age: 49.4 years, range 33.4–87.0 years, 17 female) were included. Recurrent tumors included 37/44 glioblastomas WHO grade IV and 7/44 anaplastic astrocytomas WHO grade III. Thirty (68.2%) tumors were MGMT methylated. Median treatment volume was 3.3 ccm (range, 0.5–22.8 ccm). A median number of 4 (range: 3–8) laser fibers were used. Median illumination time was 60min (range: 60–167 min). Symptomatic edema (8/44) or intratumoral hemorrhagic imbibition (7/44) did not result in any permanent morbidity. Median TTF was 7.1 months and median PRS was 13.0 months. The 2- and 5-years PRS rates were 25.0% and 4.5%. Treatment response was heterogeneous and not significantly associated with patient characteristics, treatment-related factors or molecular markers. In conclusion, iPDT was associated with promising outcome measurements in local malignant glioma recurrences in highly selected patients. Transient neurologic deterioration did not lead to any permanent morbidity. The procedure deserves further prospective evaluation particularly to identify mechanisms of favorable treatment response and prognostic factors associated with long-term survival.

scholarly journals Treatment-Induced Changes in Tumor Oxygenation Predict Photodynamic Therapy Outcome

2004 ◽  
Vol 64 (20) ◽  
pp. 7553-7561 ◽  
Author(s):  
Hsing-Wen Wang ◽  
Mary E. Putt ◽  
Michael J. Emanuele ◽  
Daniel B. Shin ◽  
Eli Glatstein ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Oxygenation ◽  
Therapy Outcome ◽  
Induced Changes

Optimizing interstitial photodynamic therapy with custom cylindrical diffusers

2018 ◽  
Vol 12 (1) ◽  
pp. e201800153 ◽  
Author(s):  
Abdul-Amir Yassine ◽  
Lothar Lilge ◽  
Vaughn Betz
Keyword(s):  
Photodynamic Therapy ◽  
Interstitial Photodynamic Therapy

mTHPC mediated interstitial photodynamic therapy of recurrent nonmetastatic base of tongue cancers: Development of a new method

Head & Neck ◽  
2012 ◽  
Vol 34 (11) ◽  
pp. 1597-1606 ◽  
Author(s):  
Baris Karakullukcu ◽  
Heike J. Nyst ◽  
Robert L. van Veen ◽  
Frank J. P. Hoebers ◽  
Olga Hamming-Vrieze ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
New Method ◽  
Base Of Tongue ◽  
Interstitial Photodynamic Therapy

Interstitial photodynamic therapy: Light fractionation effects on a preclinical model of glioblastoma

2015 ◽  
Vol 12 (3) ◽  
pp. 347 ◽  
Author(s):  
Henri-Arthur Leroy ◽  
Maximilien Vermandel ◽  
Bertrand Leroux ◽  
Serge Mordon ◽  
Nicolas Reyns
Keyword(s):  
Photodynamic Therapy ◽  
Preclinical Model ◽  
Interstitial Photodynamic Therapy

Integrated system for interstitial photodynamic therapy

2003 ◽  
Author(s):  
Stefan Andersson-Engels ◽  
Niels Bendsoe ◽  
Ann Johansson ◽  
Thomas Johansson ◽  
Sara Pǻlsson ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Integrated System ◽  
Interstitial Photodynamic Therapy
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