Mitochondrial disease activates transcripts of the unfolded protein response and cell cycle and inhibits vesicular secretion and oligodendrocyte-specific transcripts

Mitochondrion ◽  
2006 ◽  
Vol 6 (4) ◽  
pp. 161-175 ◽  
Author(s):  
Gino Cortopassi ◽  
Steven Danielson ◽  
Mansour Alemi ◽  
Shan Shan Zhan ◽  
Warren Tong ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Unfolded Protein Response ◽  
Mitochondrial Disease ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response ◽  
Vesicular Secretion

scholarly journals A novel role in cytokinesis reveals a housekeeping function for the unfolded protein response

2007 ◽  
Vol 177 (6) ◽  
pp. 1017-1027 ◽  
Author(s):  
Alicia A. Bicknell ◽  
Anna Babour ◽  
Christine M. Federovitch ◽  
Maho Niwa
Keyword(s):  
Cell Cycle ◽  
Unfolded Protein Response ◽  
Normal Cell ◽  
Growth Conditions ◽  
Unfolded Protein ◽  
Functional Capabilities ◽  
Cellular Events ◽  
The Unfolded Protein Response ◽  
Protein Response ◽  
Upr Pathway

The unfolded protein response (UPR) pathway helps cells cope with endoplasmic reticulum (ER) stress by activating genes that increase the ER's functional capabilities. We have identified a novel role for the UPR pathway in facilitating budding yeast cytokinesis. Although other cell cycle events are unaffected by conditions that disrupt ER function, cytokinesis is sensitive to these conditions. Moreover, efficient cytokinesis requires the UPR pathway even during unstressed growth conditions. UPR-deficient cells are defective in cytokinesis, and cytokinesis mutants activate the UPR. The UPR likely achieves its role in cytokinesis by sensing small changes in ER load and making according changes in ER capacity. We propose that cytokinesis is one of many cellular events that require a subtle increase in ER function and that the UPR pathway has a previously uncharacterized housekeeping role in maintaining ER plasticity during normal cell growth.

The unfolded protein response affects neuronal cell cycle protein expression: Implications for Alzheimer's disease pathogenesis

2006 ◽  
Vol 41 (4) ◽  
pp. 380-386 ◽  
Author(s):  
Jeroen J.M. Hoozemans ◽  
Jens Stieler ◽  
Elise S. van Haastert ◽  
Robert Veerhuis ◽  
Annemieke J.M. Rozemuller ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cell Cycle ◽  
Protein Expression ◽  
Unfolded Protein Response ◽  
Neuronal Cell ◽  
Cell Cycle Protein ◽  
Disease Pathogenesis ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

Cell cycle arrest mediated by WEE1 is involved in the unfolded protein response in plants

2018 ◽  
Vol 12 (5) ◽  
pp. 315-328
Author(s):  
Ki Seong Ko ◽  
Jae Yong Yoo ◽  
Nirmal Kumar Ramasamy ◽  
Rikno Harmoko ◽  
Bích Ngọc Thị Vũ ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
Cycle Arrest ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals Ribosomal Stress Couples the Unfolded Protein Response to p53-dependent Cell Cycle Arrest

2006 ◽  
Vol 281 (40) ◽  
pp. 30036-30045 ◽  
Author(s):  
Fang Zhang ◽  
Robert B. Hamanaka ◽  
Ekaterina Bobrovnikova-Marjon ◽  
John D. Gordan ◽  
Mu-Shui Dai ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
Cycle Arrest ◽  
Dependent Cell ◽  
The Unfolded Protein Response ◽  
Protein Response ◽  
Ribosomal Stress

Oestrogen-driven changes in the bovine uterus are associated with activation of the unfolded protein response

2014 ◽  
Author(s):  
Mohammed A Alfattah ◽  
Paul Anthony McGettigan ◽  
John Arthur Browne ◽  
Khalid M Alkhodair ◽  
Katarzyna Pluta ◽  
...  
Keyword(s):  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response
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