Introduction of non-invasive prenatal testing as a first-tier aneuploidy screening test: A survey among Dutch midwives about their role as counsellors

Midwifery ◽  
2018 ◽  
Vol 56 ◽  
pp. 1-8 ◽  
Author(s):  
Linda Martin ◽  
Janneke T. Gitsels-van der Wal ◽  
Marjon A. de Boer ◽  
Meredith Vanstone ◽  
Lidewij Henneman
Keyword(s):  
Screening Test ◽  
Prenatal Testing ◽  
Aneuploidy Screening ◽  
Non Invasive

scholarly journals TRIDENT-2: National Implementation of Genome-wide Non-invasive Prenatal Testing as a First-Tier Screening Test in the Netherlands

2019 ◽  
Vol 105 (6) ◽  
pp. 1091-1101 ◽  
Author(s):  
Karuna R.M. van der Meij ◽  
Erik A. Sistermans ◽  
Merryn V.E. Macville ◽  
Servi J.C. Stevens ◽  
Caroline J. Bax ◽  
...  
Keyword(s):  
The Netherlands ◽  
Screening Test ◽  
Prenatal Testing ◽  
Non Invasive ◽  
Genome Wide ◽  
National Implementation

scholarly journals Non-invasive prenatal testing for aneuploidy screening

BMJ ◽  
2020 ◽  
pp. m3930
Author(s):  
Rebecca Spencer ◽  
Hilary Hewitt ◽  
Laura McCarthy ◽  
Ruwan Wimalasundera ◽  
Pranav Pandya
Keyword(s):  
Prenatal Testing ◽  
Aneuploidy Screening ◽  
Non Invasive

scholarly journals The Knowledge, Attitude, Practices, and Satisfaction of Non-Invasive Prenatal Testing among Chinese Pregnant Women under Different Payment Schemes: A Comparative Study

2020 ◽  
Vol 17 (19) ◽  
pp. 7187
Author(s):  
Wenjun Zhu ◽  
XiaoXiao Ling ◽  
Wenru Shang ◽  
Jiayan Huang
Keyword(s):  
Genetic Counseling ◽  
Pregnant Women ◽  
Insurance Coverage ◽  
Prenatal Testing ◽  
Chi Square ◽  
Aneuploidy Screening ◽  
Logistic Regression Models ◽  
Non Invasive ◽  
Payment Schemes ◽  
Chi Square Test

Non-invasive prenatal testing (NIPT) for aneuploidy screening has been widely applied across China, and costs can affect Chinese pregnant women’s choices. This study aims to assess the knowledge, attitude, practices (KAP) and satisfaction regarding NIPT among pregnant women in China, and to further explore the relationship between payment schemes and women’s acceptability of and satisfaction with NIPT. A questionnaire survey was performed in Shenzhen and Zhengzhou, China, which separately applied “insurance coverage” and “out-of-pocket” payment scheme for NIPT. The major differences between the two cities were compared using chi-square test, Wilcoxon rank sum test, and propensity score matched analysis. Logistic regression models were applied to explore predictors for women’s acceptability and satisfaction. Compared with Zhengzhou participants, a higher proportion of Shenzhen women had heard of NIPT (87.30% vs. 64.03%), were willing to receive NIPT (91.80% vs. 80.43%) and had taken NIPT (83.12% vs. 54.54%), while their satisfaction level was lower. Having NIPT-related knowledge was associated with higher acceptability, and receiving genetic counseling helped to improve satisfaction. Besides, women with higher annual household incomes were more likely to take and be satisfied with NIPT. In conclusion, more attention should be paid to health education, subsidies for NIPT, and genetic counseling.

scholarly journals Women’s choices in non-invasive prenatal testing for aneuploidy screening: results from a single centre prior to introduction in England

2019 ◽  
Vol 105 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Adalina Sacco ◽  
Hilary Hewitt ◽  
Pranav Pandya
Keyword(s):  
Trisomy 21 ◽  
Prenatal Testing ◽  
First Trimester ◽  
Routine Care ◽  
Singleton Pregnancy ◽  
Aneuploidy Screening ◽  
Non Invasive ◽  
Contingency Model ◽  
The Uk ◽  
High Chance

ObjectiveTo evaluate patient choices and uptake of non-invasive prenatal testing (NIPT) for aneuploidy screening offered in a contingency model as part of routine care.MethodWe retrospectively reviewed data for all women with a singleton pregnancy attending for routine first trimester screening over an 18-month period. Women with a ‘high-chance’ of trisomy 21, 18 or 13 (≥1:150) were offered the choice of no further testing, NIPT or invasive testing, in line with the screening pathway recommended by the UK National Screening Committee.ResultsOf 9342 women attending for a first trimester ultrasound scan, 7939 women were included in this study. Of these, 352 had a high-chance screening result for trisomy 21, and 291 (82.7%) opted for NIPT. The proportion of women opting for NIPT decreased as the chance of trisomy 21 increased: uptake was 93.2%, 90.0%, 77.1% and 47.2% for women with a chance of 1:100–150, 1:50–99, 1:10–49 and >1:10, respectively. 516 women (5.5%) accessed primary NIPT screening in the private sector, and 638 women (6.8%) declined any aneuploidy screening or testing.ConclusionImplementation of NIPT testing in a contingency model has a high uptake in a non-research National Health Service setting; the rate of uptake is related to the combined test risk result.

Non-invasive Prenatal Testing (NIPT)

2019 ◽  
Author(s):  
Courtney Manning ◽  
Mary-Alice Abbott
Keyword(s):  
High Risk ◽  
Screening Test ◽  
Sex Chromosome ◽  
Diagnostic Testing ◽  
Prenatal Testing ◽  
Trisomy 18 ◽  
Trisomy 13 ◽  
Non Invasive ◽  
Risk Result ◽  
Cell Free Fetal Dna

Non-invasive prenatal testing (NIPT) is a screening test that can determine if a pregnancy is at high risk for the common aneuploidies by analyzing cell-free fetal DNA in the maternal bloodstream. The screening includes trisomy 21, trisomy 18, and trisomy 13, with the option of screening for sex chromosome aneuploidy and fetal sex. Traditionally this testing is offered to women that are at high risk for these aneuploidies, most commonly women of advanced maternal age. Individuals that receive a high risk result on NIPT should be offered diagnostic testing to confirm the result. New forms of NIPT have recently emerged, however the use of this technology as a screening test for other genetic conditions is not currently recommended by national professional society guidelines. Patients should be counseled and consented for NIPT, as this is an optional screening test. This review contains 2 tables, and 39 references. Keywords: NIPT, non-invasive prenatal testing, aneuploidy, Down syndrome, trisomy 18, trisomy 13, Turner syndrome, microdeletions, diagnostic testing

scholarly journals Aneuploidy screening by non-invasive prenatal testing in twin pregnancy

2017 ◽  
Vol 49 (4) ◽  
pp. 470-477 ◽  
Author(s):  
L. Fosler ◽  
P. Winters ◽  
K. W. Jones ◽  
K. J. Curnow ◽  
A. J. Sehnert ◽  
...  
Keyword(s):  
Twin Pregnancy ◽  
Prenatal Testing ◽  
Aneuploidy Screening ◽  
Non Invasive
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