Simultaneous determination of third-generation synthetic cannabinoids in oral fluids using cyclodextrin-silica porous sorbents

2021 ◽  
pp. 106915
Author(s):  
Carolina Belenguer-Sapiña ◽  
Roberto Sáez-Hernández ◽  
Enric Pellicer-Castell ◽  
Sergio Armenta ◽  
Adela.R. Mauri-Aucejo
Keyword(s):  
Simultaneous Determination ◽  
Synthetic Cannabinoids ◽  
Third Generation ◽  
Oral Fluids ◽  
Porous Sorbents

Determination of Third-Generation Synthetic Cannabinoids in Oral Fluids

2020 ◽  
Author(s):  
Aitor Sorribes-Soriano ◽  
Josep Verdeguer ◽  
Agustín Pastor ◽  
Sergio Armenta ◽  
Francesc A Esteve-Turrillas
Keyword(s):  
Oral Fluid ◽  
Synthetic Cannabinoids ◽  
High Sensitivity ◽  
Gas Chromatography Mass Spectrometry ◽  
Third Generation ◽  
Model Compounds ◽  
Oral Fluids ◽  
Sensitive Determination ◽  
Packed Sorbent

Abstract A procedure has been developed for the determination of third-generation synthetic cannabinoids in oral fluid samples by using a semi-automated microextraction by packed sorbent (MEPS) procedure and gas chromatography–mass spectrometry (GC–MS) determination. Five synthetic cannabinoids were employed as model compounds 5F-ADB, MMB-CHMICA, THJ-2201, CUMYL-4CN-BINACA and MDMB-CHMCZCA. The most adequate operative conditions for MEPS were evaluated giving quantitative recoveries, from 89 to 124%, in synthetic and field saliva samples spiked with 125 and 250 μg/L of the studied cannabinoids, with the exception of MDMB-CHMCZCA in field saliva samples that provided slightly lower recoveries from 62 to 66%. A high sensitivity was obtained for the proposed MEPS-GC–MS procedure with limits of detection from 10 to 20 μg/L. The obtained results demonstrate the high potential of MEPS-GC–MS combination for semi-automated, selective and sensitive determination of synthetic cannabinoids in oral fluid samples.

Simultaneous determination of synthetic cannabinoids and their metabolites in human hair using LC-MS/MS and application to human hair

2020 ◽  
Vol 306 ◽  
pp. 110058 ◽  
Author(s):  
Byungsuk Cho ◽  
Han Soo Cho ◽  
Junghyun Kim ◽  
Juhyun Sim ◽  
Ilung Seol ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Human Hair ◽  
Synthetic Cannabinoids

A general computer program for the extended plate overlap algorithm

1978 ◽  
Vol 48 ◽  
pp. 287-293 ◽  
Author(s):  
Chr. de Vegt ◽  
E. Ebner ◽  
K. von der Heide
Keyword(s):  
Computer Program ◽  
Simultaneous Determination ◽  
General Computer Program ◽  
General Computer

In contrast to the adjustment of single plates a block adjustment is a simultaneous determination of all unknowns associated with many overlapping plates (star positions and plate constants etc. ) by one large adjustment. This plate overlap technique was introduced by Eichhorn and reviewed by Googe et. al. The author now has developed a set of computer programmes which allows the adjustment of any set of contemporaneous overlapping plates. There is in principle no limit for the number of plates, the number of stars, the number of individual plate constants for each plate, and for the overlapping factor.

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