Development of an analytical method based on citric acid coated magnetite nanoparticles assisted dispersive magnetic solid-phase extraction for the enrichment and extraction of sildenafil, tadalafil, vardenafil and avanafil in human plasma and urine prior to determination by LC-MS/MS

2019 ◽  
Vol 147 ◽  
pp. 269-276 ◽  
Author(s):  
Elif Öztürk Er ◽  
Erhan Akkaya ◽  
Belma Özbek ◽  
Sezgin Bakırdere
Keyword(s):  
Citric Acid ◽  
Solid Phase Extraction ◽  
Human Plasma ◽  
Magnetite Nanoparticles ◽  
Analytical Method ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
Phase Extraction ◽  
Human Plasma And Urine ◽  
Magnetic Solid

Magnetic solid-phase extraction based on a trimethylstearylammonium bromide coated Fe3O4/SiO2 composite for determination of adriamycin hydrochloride in human plasma and urine by HPLC-FLD

2014 ◽  
Vol 6 (17) ◽  
pp. 6736-6744 ◽  
Author(s):  
Nengxuan Ma ◽  
Lin Zhang ◽  
Ruijin Li ◽  
Yehong Zhou ◽  
Zongwei Cai ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Human Plasma ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
Phase Extraction ◽  
Human Plasma And Urine ◽  
Magnetic Solid

A novel TSAB coated Fe3O4/SiO2 MNP was fabricated and used as the adsorbent for magnetic solid-phase extraction of ADR with HPLC-FLD.

Magnetic Solid-Phase Extraction of Drugs and Pesticides from Human Plasma using COOH-mMWCNTs

2020 ◽  
Author(s):  
Heesung Moon ◽  
Jiwon Park ◽  
Jinwoo Hwang ◽  
Heesun Chung
Keyword(s):  
Carbon Nanotubes ◽  
Carboxylic Acid ◽  
Solid Phase Extraction ◽  
Human Plasma ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
University Hospital ◽  
Phase Extraction ◽  
National University ◽  
Magnetic Solid

Abstract Carbon nanotubes (CNT) are useful for extracting chemical compounds due to their properties, such as surface area and the potential for chemical modification. Especially the formation of carbon nanotubes with carboxylic acid functional group makes them disperse in water-based samples and have strong interaction forces with cationizable analytes. Based on these features, carboxylic acid functionalized multi-walled carbon nanotubes (COOH-MWCNTs) have been used as extraction sorbents. CNT also can be gathered using an external magnet by forming complex with iron oxide (Fe3O4) magnetic nanoparticles (MNPs). In this study, COOH-MWCNTs with MNPs were subjected to magnetic solid phase extraction (mSPE) in order to extract the targeted substances such as diphenhydramine, doxylamine, tramadol, escitalopram, zolpidem, diphenamid, paclobutrazol, hexaconazole, cyproconazole, and mepronil from human plasma samples. The following five factors were optimized: [1] the ratio of COOH-MWCNTs to MNPs as a sorbent from 1: 1 to 1: 4; [2] sorbent amount starting from 12.5% to 75%; [3] sample pH tested pH 2 to pH 10 with 1 N hydrochloride and 1 N sodium hydroxide; [4] agitating time from 0 min to 4 min; [5] elution solvent. LOD of 10 targeted substances in human plasma were in the range of 0.1 to 0.4 mg/L. The recovery of targeted substances (except diphenamid) in human plasma was 73.06–110.28% for intra-day, 83.00–107.70% for inter-day and the precision (RSD, %) in human plasma was 0.3–13.3% for intra-day, 2.9–15.6%. The method was applied to 9 authentic biological samples from overdose patients in the emergency room of Chung-nam National University Hospital. The performance of mSPE was compared with the liquid–liquid extraction (LLE) method using ethyl acetate. The results showed that the newly developed method in this study can be used for screening analysis in forensic and clinical toxicology.

Trace amount determination of Cd(ii), Pb(ii) and Ni(ii) ions in agricultural and seafood samples after magnetic solid phase extraction by MIL-101(Cr)/phenylthiosemicarbazide-functionalized magnetite nanoparticle composite

2018 ◽  
Vol 42 (21) ◽  
pp. 17636-17643 ◽  
Author(s):  
Masoomeh Mehraban ◽  
Mahboobeh Manoochehri ◽  
Faramarz Afshar Taromi
Keyword(s):  
Heavy Metals ◽  
Solid Phase Extraction ◽  
Magnetite Nanoparticles ◽  
Trace Amount ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
Phase Extraction ◽  
Magnetite Nanoparticle ◽  
Magnetic Solid

Herein, a novel nanosorbent consisting of phenylthiosemicarbazide magnetite nanoparticles and MIL-101(Cr) was synthesized, characterized and utilized to magnetic solid phase extraction of some heavy metals in various agricultural and seafood samples.

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