Arsenic speciation based on amine-functionalized bimodal mesoporous silica nanoparticles by ultrasound assisted-dispersive solid-liquid multiple phase microextraction

2017 ◽  
Vol 130 ◽  
pp. 137-146 ◽  
Author(s):  
Hamid Shirkhanloo ◽  
Mehri Ghazaghi ◽  
Alimorad Rashidi ◽  
Amir Vahid
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Arsenic Speciation ◽  
Multiple Phase ◽  
Amine Functionalized ◽  
Ultrasound Assisted ◽  
Solid Liquid

Curcumin-Loaded Amine-Functionalized Mesoporous Silica Nanoparticles Inhibit α-Synuclein Fibrillation and Reduce Its Cytotoxicity-Associated Effects

Langmuir ◽  
2016 ◽  
Vol 32 (50) ◽  
pp. 13394-13402 ◽  
Author(s):  
Nayere Taebnia ◽  
Dina Morshedi ◽  
Soheila Yaghmaei ◽  
Farhang Aliakbari ◽  
Fatemeh Rahimi ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized

scholarly journals Isolation and Quantification of miRNA from the Biomolecular Corona on Mesoporous Silica Nanoparticles

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1196
Author(s):  
Carla Vidaurre-Agut ◽  
Eva María Rivero-Buceta ◽  
Christopher C. Landry ◽  
Pablo Botella
Keyword(s):  
Prostate Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Incubation Temperature ◽  
Mesoporous Silica Nanoparticles ◽  
Nanoparticle Concentration ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized ◽  
Commercial Kit ◽  
Higher Sensitivity

To understand the factors that control the formation of the biomolecular corona, a systematic study of the adsorption of several miRNAs shown to be important in prostate cancer on amine-functionalized mesoporous silica nanoparticles (MSN-NH2) has been performed. Process parameters including miRNA type, nanoparticle concentration, incubation temperature and incubation time were investigated, as well as the potential competition for adsorption between different miRNA molecules. The influence of proteins and particle PEGylation on miRNA adsorption were also explored. We found that low particle concentrations and physiological temperature both led to increased miRNA adsorption. Adsorption of miRNA was also higher when proteins were present in the same solution; reducing or preventing protein adsorption by PEGylating the MSNs hindered adsorption. Finally, the amount of miRNA adsorbed from human serum by MSN-NH2 was compared to a commercial miRNA purification kit (TaqMan®, Life Technologies, Carlsbad, CA, USA). MSN-NH2 adsorbed six times as much miRNA as the commercial kit, demonstrating higher sensitivity to subtle up- and downregulation of circulating miRNA in the blood of patients.

scholarly journals Surface adsorption of Nordic aquatic fulvic acid on amine-functionalized and non-functionalized mesoporous silica nanoparticles

2018 ◽  
Vol 5 (9) ◽  
pp. 2162-2171 ◽  
Author(s):  
Sanjaya Jayalath ◽  
Sarah C. Larsen ◽  
Vicki H. Grassian
Keyword(s):  
Organic Matter ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Fulvic Acid ◽  
Natural Organic Matter ◽  
Mesoporous Silica Nanoparticles ◽  
Surface Adsorption ◽  
Functionalized Mesoporous Silica ◽  
Amine Functionalized

Mesoporous silica nanoparticles (MSNs) have the potential to be released into the environment and to then adsorb natural organic matter.

scholarly journals Functionalization of Hollow Mesoporous Silica Nanoparticles for Improved 5-FU Loading

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Xiaodong She ◽  
Lijue Chen ◽  
Chengpeng Li ◽  
Canzhong He ◽  
Li He ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Electrostatic Force ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Hollow Structure ◽  
Loading Capacity ◽  
Amine Functionalized ◽  
Alkaline Conditions ◽  
Hollow Mesoporous Silica

Hollow mesoporous silica nanoparticles were successfully fabricated and functionalized with appropriate silanes. After modifications, amine, carboxyl, cyano, and methyl groups were grafted onto the nanoparticles and all functionalized hollow mesoporous silica nanoparticles maintained a spherical and hollow structure with a mean diameter of ~120 nm and a shell thickness of ~10 nm. The loading capacity of the hollow mesoporous silica nanoaprticles to the anticancer drug, 5-fluorouracil, can be controlled via precise functionalization. The presence of amine groups on the surface of nanoparticles resulted in the highest loading capacity of 28.89%, due to the amine functionalized nanoparticles having a similar hydrophilicity but reverse charge to the drug. In addition, the change in pH leads to the variation of the intensity of electrostatic force between nanoparticles and the drug, which finally affects the loading capacity of amine functionalized hollow mesoporous silica nanoparticles to some extent. Higher drug loading was observed at pH of 7.4 and 8.5 as 5-fluorouracil becomes more deprotonated in alkaline conditions. The improved drug loading capacity by amine functionalized hollow mesoporous silica nanoparticles has demonstrated that they can become potential intracellular 5-fluorouracil delivery vehicles for cancers.

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