Antimicrobial activity and biofilm inhibition of riparins I, II and III and ultrastructural changes in multidrug-resistant bacteria of medical importance

2020 ◽  
Vol 149 ◽  
pp. 104529
Author(s):  
Jorge Belém Oliveira-Júnior ◽  
Everton Morais da Silva ◽  
Dyana Leal Veras ◽  
Karla Raíza Cardoso Ribeiro ◽  
Catarina Fernandes de Freitas ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Multidrug Resistant ◽  
Ultrastructural Changes ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Biofilm Inhibition ◽  
Medical Importance

scholarly journals Antimicrobial activity of surfactants produced by Bacillus subtilis R14 against multidrug-resistant bacteria

2007 ◽  
Vol 38 (4) ◽  
pp. 704-709 ◽  
Author(s):  
Paulo André Vicente Fernandes ◽  
Isabel Renata de Arruda ◽  
Antônio Fernando Amatto Botelho dos Santos ◽  
Ana Albertina de Araújo ◽  
Ana Maria Souto Maior ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Bacillus Subtilis ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria

scholarly journals Construction of Zinc Oxide into Different Morphological Structures to Be Utilized as Antimicrobial Agent against Multidrug Resistant Bacteria

2015 ◽  
Vol 2015 ◽  
pp. 1-20 ◽  
Author(s):  
M. F. Elkady ◽  
H. Shokry Hassan ◽  
Elsayed E. Hafez ◽  
Ahmed Fouad
Keyword(s):  
Antimicrobial Activity ◽  
Zinc Oxide ◽  
Surface Area ◽  
High Surface ◽  
Multidrug Resistant ◽  
Annealing Process ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Nano Zno ◽  
Zno Nanotubes

Nano-ZnO has been successfully implemented in particles, rods, and tubes nanostructures via sol-gel and hydrothermal techniques. The variation of the different preparation parameters such as reaction temperature, time, and stabilizer agents was optimized to attain different morphological structures. The influence of the microwave annealing process on ZnO crystallinity, surface area, and morphological structure was monitored using XRD, BET, and SEM techniques, respectively. The antimicrobial activity of zinc oxide produced in nanotubes structure was examined against four different multidrug resistant bacteria: Gram-positive (Staphylococcus aureusandBacillus subtilis) and Gram-negative (Escherichia coliandPseudomonas aeruginosa) strains. The activity of produced nano-ZnO was determined by disc diffusion technique and the results revealed that ZnO nanotubes recorded high activity against the studied strains due to their high surface area equivalent to 17.8 m2/g. The minimum inhibitory concentration (MIC) of ZnO nanotubes showed that the low concentrations of ZnO nanotubes could be a substitution for the commercial antibiotics when approached in suitable formula. Although the annealing process of ZnO improves the degree of material crystallinity, however, it declines its surface area and consequently its antimicrobial activity.

scholarly journals The Spectrum of Design Solutions for Improving the Activity-Selectivity Product of Peptide Antibiotics against Multidrug-Resistant Bacteria and Prostate Cancer PC-3 Cells

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3526
Author(s):  
Davor Juretić ◽  
Anja Golemac ◽  
Denise E. Strand ◽  
Keshi Chung ◽  
Nada Ilić ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Antimicrobial Activity ◽  
Anticancer Activity ◽  
Wide Spectrum ◽  
Multidrug Resistant ◽  
Cell Penetrating Peptides ◽  
Resistant Bacteria ◽  
Peptide Antibiotics ◽  
Multidrug Resistant Bacteria ◽  
Selective Antimicrobial Activity

The link between the antimicrobial and anticancer activity of peptides has long been studied, and the number of peptides identified with both activities has recently increased considerably. In this work, we hypothesized that designed peptides with a wide spectrum of selective antimicrobial activity will also have anticancer activity, and tested this hypothesis with newly designed peptides. The spectrum of peptides, used as partial or full design templates, ranged from cell-penetrating peptides and putative bacteriocin to those from the simplest animals (placozoans) and the Chordata phylum (anurans). We applied custom computational tools to predict amino acid substitutions, conferring the increased product of bacteriostatic activity and selectivity. Experiments confirmed that better overall performance was achieved with respect to that of initial templates. Nine of our synthesized helical peptides had excellent bactericidal activity against both standard and multidrug-resistant bacteria. These peptides were then compared to a known anticancer peptide polybia-MP1, for their ability to kill prostate cancer cells and dermal primary fibroblasts. The therapeutic index was higher for seven of our peptides, and anticancer activity stronger for all of them. In conclusion, the peptides that we designed for selective antimicrobial activity also have promising potential for anticancer applications.

scholarly journals Colistin and Kanamycin Together in Association with Coridothymus capitatus to Enhance their Antimicrobial Activity and Fight Multidrug-Resistance Pathogens

2020 ◽  
Vol 11 (2) ◽  
pp. 8608-8625
Keyword(s):  
Antimicrobial Activity ◽  
Antibiotic Resistance ◽  
Essential Oil ◽  
Pharmaceutical Formulations ◽  
Multidrug Resistant ◽  
Therapeutic Strategies ◽  
Synergistic Action ◽  
Resistant Bacteria ◽  
Synergistic Activity ◽  
Multidrug Resistant Bacteria

It should be remembered that bacteria continue to spread and develop new types of resistance, so further actions are needed to deal with antibiotic resistance. As a result, antibacterial drugs have become less effective, resulting in the accelerated discovery of available alternative treatments, including essential oils. The aim of this work was to intensify and promote the action of two antibiotics, kanamycin, and colistin, to fight antibiotic resistance thanks to the action of essential oil obtained from the flowers of Coridothymus capitatus grown on the Iblei mountains. To this end, a comparison of biological and chemical assays was carried out. The results showed a broad antimicrobial power of the essential oil itself and a great synergistic activity in combination with Kanamycin and Colistin against multidrug-resistant bacteria. These combinations increased the range of antibiotics, leading us to speculate that it could be incorporated into new pharmaceutical formulations for therapies of infections caused by increasingly dangerous bacteria. Antibiotic resistance represents an ever-greater danger to human health. This work re-evaluates the use of colistin and kanamycin thanks to the synergistic action found with the addition of a natural substance to pave the way for new therapeutic strategies.

scholarly journals Synergistic Antimicrobial Activity of Camellia sinensis and Juglans regia against Multidrug-Resistant Bacteria

PLoS ONE ◽  
2015 ◽  
Vol 10 (2) ◽  
pp. e0118431 ◽  
Author(s):  
Amber Farooqui ◽  
Adnan Khan ◽  
Ilaria Borghetto ◽  
Shahana U. Kazmi ◽  
Salvatore Rubino ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Camellia Sinensis ◽  
Juglans Regia ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria

scholarly journals Production of Silver Nanoparticles with Strong and Stable Antimicrobial Activity against Highly Pathogenic and Multidrug Resistant Bacteria

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Amr T. M. Saeb ◽  
Ahmad S. Alshammari ◽  
Hessa Al-Brahim ◽  
Khalid A. Al-Rubeaan
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Zeta Potential ◽  
Pseudomonas Putida ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Visible Spectroscopy ◽  
Multidrug Resistant Bacteria ◽  
Highly Pathogenic ◽  
Particle Stability

Aims. To synthesize, characterize, and analyze antimicrobial activity of AgNPs ofEscherichia hermannii(SHE),Citrobacter sedlakii(S11P), andPseudomonas putida(S5).Methods. The synthesized AgNPs were examined using ultraviolet-visible spectroscopy (UV-vis) and, zeta potential, and the size and the morphology obtained from the three different isolates were also confirmed by TEM.Results. Among the three isolates tested, SHE showed the best antimicrobial activity due to the presence of small (4–12 nm) and stable (−22 mV) AgNPs. Stability of AgNPs was also investigated and found to be dependent on the nature of isolates.Conclusion. Produced AgNPs showed particle stability and antimicrobial efficacy up to 90 days of production. Our AgNPs exhibited greater antimicrobial activity compared with gentamicin againstP. aeruginosaisolates and vancomycin againstS. aureusand MRSA isolates at very low concentration (0.0002 mg per Microliters).

scholarly journals Study of antimicrobial activity of iodine coordination complexes against multidrug resistant bacteria

2018 ◽  
Vol 74 (1) ◽  
pp. 140-151
Author(s):  
A. B. Jumagaziyeva ◽  
◽  
S. T. Кеnesheva ◽  
D. B. Bakytov ◽  
S. B. Berdibay ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Coordination Complexes ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria
Sign in / Sign up

Export Citation Format

Share Document