Novel derivatives of plant monomeric phenolics: act as inhibitors of bacterial cell-to-cell communication

2020 ◽  
Vol 141 ◽  
pp. 103856
Author(s):  
Nishi Srivastava ◽  
Surabhi Tiwari ◽  
Kalpna Bhandari ◽  
Ajaya K Biswal ◽  
A.K.S. Rawat
Keyword(s):  
Bacterial Cell ◽  
Cell Communication ◽  
Derivatives Of

Bacterial cell leakage potential of newly synthesized quinazoline derivatives of 1,5‐benzodiazepines analogue

2020 ◽  
Vol 57 (4) ◽  
pp. 1545-1558
Author(s):  
Apoorva Misra ◽  
Jaya Dwivedi ◽  
Shruti Shukla ◽  
Dharma Kishore ◽  
Swapnil Sharma
Keyword(s):  
Bacterial Cell ◽  
Quinazoline Derivatives ◽  
Derivatives Of ◽  
Cell Leakage

RNAIII Inhibiting Peptide (RIP) and Derivatives as Potential Tools for the Treatment of S. aureus Biofilm Infections

2019 ◽  
Vol 18 (24) ◽  
pp. 2068-2079 ◽  
Author(s):  
Michele Ciulla ◽  
Antonio Di Stefano ◽  
Lisa Marinelli ◽  
Ivana Cacciatore ◽  
Giuseppe Di Biase
Keyword(s):  
Medical Devices ◽  
Biofilm Formation ◽  
Heart Valves ◽  
Cell Communication ◽  
Antibiofilm Activity ◽  
Host Immune System ◽  
Excellent Growth ◽  
Potential Applications ◽  
Novel Strategy ◽  
Derivatives Of

S. aureus under the biofilm mode of growth is often related to several nosocomial infections, more frequently associated with indwelling medical devices (catheters, prostheses, portacaths or heart valves). As a biofilm, the biopolymer matrix provides an excellent growth medium, increasing the tolerance to antibiotics and host immune system. To date, the antimicrobial therapy alone is not effective. A novel strategy to prevent biofilm formation is based on the interference with the bacterial cell–cell communication, a process known as quorum sensing (QS) and mediated by the RNA-III-activating peptide (RAP) and its target protein TRAP (Target of RAP). The RNAIII inhibiting peptide (RIP) is able to inhibit S. aureus pathogenesis by disrupting QS mechanism competing with RAP, thus inhibiting the phosphorylation of TRAP. This alteration leads to a reduced adhesion and to the inhibition of RNAIII synthesis, with the subsequent suppression of toxins synthesis. The present paper will provide an overview on the activity and potential applications of RIP as biofilm inhibiting compound, useful in the management of S. aureus biofilm infections. Moreover, medicinal chemistry strategies have been examined to better understand which modifications and/or structure alterations were able to produce new derivatives of this QS inhibitor with an improved antibiofilm activity.

Prokaryotic multicellularity: a nanopore array for bacterial cell communication

2013 ◽  
Vol 27 (6) ◽  
pp. 2293-2300 ◽  
Author(s):  
Josef Lehner ◽  
Susanne Berendt ◽  
Bastian Dörsam ◽  
Rebeca Pérez ◽  
Karl Forchhammer ◽  
...  
Keyword(s):  
Bacterial Cell ◽  
Cell Communication

scholarly journals A Pro-Drug Approach for Selective Modulation of AI-2-Mediated Bacterial Cell-to-Cell Communication

Sensors ◽  
2012 ◽  
Vol 12 (3) ◽  
pp. 3762-3772 ◽  
Author(s):  
Min Guo ◽  
Sonja Gamby ◽  
Shizuka Nakayama ◽  
Jacqueline Smith ◽  
Herman O. Sintim
Keyword(s):  
Bacterial Cell ◽  
Cell Communication ◽  
Selective Modulation

scholarly journals Derivatives of Ribosome-Inhibiting Antibiotic Chloramphenicol Inhibit the Biosynthesis of Bacterial Cell Wall

2018 ◽  
Vol 4 (7) ◽  
pp. 1121-1129 ◽  
Author(s):  
Sivan Louzoun Zada ◽  
Keith D. Green ◽  
Sanjib K. Shrestha ◽  
Ido M. Herzog ◽  
Sylvie Garneau-Tsodikova ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Derivatives Of

Microfabricated ratchet structure integrated concentrator arrays for synthetic bacterial cell-to-cell communication assays

Lab on a Chip ◽  
2012 ◽  
Vol 12 (20) ◽  
pp. 3914 ◽  
Author(s):  
Seongyong Park ◽  
Xiaoqiang Hong ◽  
Woon Sun Choi ◽  
Taesung Kim
Keyword(s):  
Bacterial Cell ◽  
Cell Communication
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