Exploring T & B-cell epitopes and designing multi-epitope subunit vaccine targeting integration step of HIV-1 lifecycle using immunoinformatics approach

2019 ◽  
Vol 137 ◽  
pp. 103791 ◽  
Author(s):  
Faruq Abdulla ◽  
Utpal Kumar Adhikari ◽  
M. Kamal Uddin
Keyword(s):  
B Cell ◽  
Subunit Vaccine ◽  
Integration Step ◽  
B Cell Epitopes ◽  
Hiv 1

A synergistic effect of a combined bivalent DNA–protein anti-HIV-1 vaccine containing multiple T- and B-cell epitopes of HIV-1 proteins

2008 ◽  
Vol 45 (3) ◽  
pp. 661-669 ◽  
Author(s):  
Sergei I. Bazhan ◽  
Larisa I. Karpenko ◽  
Leonid R. Lebedev ◽  
Roman V. Uzhachenko ◽  
Pavel A. Belavin ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
B Cell ◽  
B Cell Epitopes ◽  
Anti Hiv ◽  
Hiv 1

Sequence Uniqueness as a Molecular Signature of HIV-1-Derived B-Cell Epitopes

2009 ◽  
Vol 22 (3) ◽  
pp. 639-646 ◽  
Author(s):  
A. Lucchese ◽  
R. Serpico ◽  
V. Crincoli ◽  
Y. Shoenfeld ◽  
D. Kanduc
Keyword(s):  
B Cell ◽  
Molecular Signature ◽  
B Cell Epitopes ◽  
Hiv 1

B-cell epitopes in HIV-1 Tat and Rev proteins colocalize with T-cell epitopes and with functional domains

1997 ◽  
Vol 51 (10) ◽  
pp. 480-487 ◽  
Author(s):  
M Tähtinen ◽  
A Ranki ◽  
S-L Valle ◽  
V Ovod ◽  
K Krohn
Keyword(s):  
T Cell ◽  
B Cell ◽  
Functional Domains ◽  
T Cell Epitopes ◽  
B Cell Epitopes ◽  
Hiv 1

Two B cell epitopes of HIV-1 Tat protein have limited antigenic polymorphism in geographically diverse HIV-1 strains

Vaccine ◽  
2001 ◽  
Vol 19 (13-14) ◽  
pp. 1738-1746 ◽  
Author(s):  
Gideon Goldstein ◽  
Gordon Tribbick ◽  
Kelledy Manson
Keyword(s):  
B Cell ◽  
Tat Protein ◽  
B Cell Epitopes ◽  
Hiv 1

Map of Sequential B Cell Epitopes of the HIV-1 Transmembrane Protein Using Human Antibodies as Probe

Intervirology ◽  
1990 ◽  
Vol 31 (6) ◽  
pp. 327-338 ◽  
Author(s):  
Jaap Goudsmit ◽  
Rob H. Meloen ◽  
Robert Brasseur
Keyword(s):  
B Cell ◽  
Transmembrane Protein ◽  
B Cell Epitopes ◽  
Human Antibodies ◽  
Hiv 1

scholarly journals CD4+ T Cells Induced by Tuberculosis Subunit Vaccine H1 Can Improve the HIV-1 Env Humoral Response by Intrastructural Help

Vaccines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 604
Author(s):  
Stephan Klessing ◽  
Vladimir Temchura ◽  
Pierre Tannig ◽  
Antonia Sophia Peter ◽  
Dennis Christensen ◽  
...  
Keyword(s):  
B Cell ◽  
Subunit Vaccine ◽  
Plasma Cells ◽  
Neutralizing Antibody ◽  
B Cell Differentiation ◽  
T Helper ◽  
Th Cells ◽  
Gag Protein ◽  
Helper Epitope ◽  
Hiv 1

The induction of a potent and long-lasting, broadly neutralizing antibody response is one of the most promising approaches in HIV-1 vaccination. Recently, we demonstrated that Gag-specific T helper cells induced by DNA priming can enhance and modulate the HIV Env-specific B cell response upon virus-like particle (VLP) boost by intrastructural help (ISH). In order to minimize the induction of potentially harmful HIV specific TH cells, we explored the possibility to harness the heterologous TH cells induced by a recombinant tuberculosis subunit vaccine H1, which contains a fusion protein of Ag85B and ESAT-6 antigens in combination with the liposomal adjuvant CAF01. To provide ISH, immunodominant MHC-II restricted peptides from the H1 vaccine were genetically incorporated into the HIV 1 Gag protein and used for HIV VLP production. ISH effects on Env-specific antibody levels and B cell differentiation were analyzed in mice primed against H1 and boosted with VLPs. In contrast to non-primed mice, a significant increase of Env-specific IgG levels for up to 26 weeks after the last immunization was observed. This increase was largely caused by elevated IgG2b and IgG2c levels in mice that received H1 priming. Additionally, ISH enhanced the frequency of Env-specific long-lived plasma cells in the bone marrow. In this study, we were able to demonstrate that a heterologous prime-boost regimen consisting of the H1 tuberculosis subunit vaccine and T helper epitope modified HIV-1 VLPs resulted in enhanced HIV Env antibody and B cell responses, mediated by intrastructural help.

Mapping of B-cell epitopes in rabbits immunised with various gag antigens for the production of HIV-1 gag capture ELISA reagents

2000 ◽  
Vol 238 (1-2) ◽  
pp. 69-80 ◽  
Author(s):  
Claudia Devito ◽  
Michael Levi ◽  
Kristina Broliden ◽  
Jorma Hinkula
Keyword(s):  
B Cell ◽  
B Cell Epitopes ◽  
Capture Elisa ◽  
Hiv 1

Mapping of two new human B-cell epitopes on HIV-1 gp120

AIDS ◽  
1992 ◽  
Vol 6 (12) ◽  
pp. 1451-1456 ◽  
Author(s):  
Philip Kusk ◽  
Kenn Holmbäck ◽  
Bjarneø Lindhardt ◽  
Egil F. Hulgaard ◽  
Thomas H. Bugge
Keyword(s):  
B Cell ◽  
B Cell Epitopes ◽  
Hiv 1 ◽  
Human B Cell
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