Association between the mannose-binding lectin (MBL)-2 gene variants and serum MBL with pulmonary tuberculosis: An update meta-analysis and systematic review

2019 ◽  
Vol 132 ◽  
pp. 374-380 ◽  
Author(s):  
Xiang Tong ◽  
Qunfang Wan ◽  
Zhenzhen Li ◽  
Sitong Liu ◽  
Jizhen Huang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pulmonary Tuberculosis ◽  
Meta Analysis ◽  
Mannose Binding Lectin ◽  
Gene Variants ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Mannose-Binding Lectin Promoter Polymorphisms and Gene Variants in Pulmonary Tuberculosis Patients from Cantabria (Northern Spain)

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
J.-Gonzalo Ocejo-Vinyals ◽  
Lucía Lavín-Alconero ◽  
Pablo Sánchez-Velasco ◽  
M.-Ángeles Guerrero-Alonso ◽  
Fernando Ausín ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Convincing Evidence ◽  
Mannose Binding Lectin ◽  
Gene Variants ◽  
Northern Spain ◽  
Promoter Polymorphisms ◽  
Increased Risk ◽  
Mannose Binding ◽  
Lectin Promoter ◽  
Binding Lectin

Mannose-binding lectin is a central molecule of the innate immune system. Mannose-binding lectin 2 promoter polymorphisms and structural variants have been associated with susceptibility to tuberculosis. However, contradictory results among different populations have been reported, resulting in no convincing evidence of association between mannose-binding lectin 2 and susceptibility to tuberculosis. For this reason, we conducted a study in a well genetically conserved Spanish population in order to shed light on this controversial association. We analysed the six promoter and structural mannose-binding lectin 2 gene variants in 107 patients with pulmonary tuberculosis and 441 healthy controls. Only D variant and HYPD haplotype were significantly more frequents in controls which would indicate that this allele could confer protection against pulmonary tuberculosis, but this difference disappeared after statistical correction. Neither the rest of alleles nor the haplotypes were significantly associated with the disease. These results would indicate that mannose-binding lectin promoter polymorphisms and gene variants would not be associated with an increased risk to pulmonary tuberculosis. Despite the slight trend of the D allele and HYPD haplotype in conferring protection against pulmonary tuberculosis, susceptibility to this disease would probably be due to other genetic factors, at least in our population.

scholarly journals Role of mannose binding lectin gene variants on its protein levels and macrophage phagocytosis with liveMycobacterium tuberculosisin pulmonary tuberculosis

2006 ◽  
Vol 46 (3) ◽  
pp. 433-437 ◽  
Author(s):  
Paramasivam Selvaraj ◽  
Mohideen S. Jawahar ◽  
Dhanushkodi N. Rajeswari ◽  
Kalichamy Alagarasu ◽  
Mohankumar Vidyarani ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Mannose Binding Lectin ◽  
Gene Variants ◽  
Lectin Gene ◽  
Protein Levels ◽  
Macrophage Phagocytosis ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Mannose-Binding Lectin Codon 54 Gene Polymorphism and Vulvovaginal Candidiasis: A Systematic Review and Meta-Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Bojan Nedovic ◽  
Brunella Posteraro ◽  
Emanuele Leoncini ◽  
Alberto Ruggeri ◽  
Rosarita Amore ◽  
...  
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Meta Analysis ◽  
Vulvovaginal Candidiasis ◽  
Mannose Binding Lectin ◽  
Innate Immune ◽  
Host Susceptibility ◽  
Wild Type ◽  
Mannose Binding ◽  
Binding Lectin

Mannose-binding lectin (MBL) plays a key role in the human innate immune response. It has been shown that polymorphisms in theMBL2gene, particularly at codon 54 (variant alleleB; wild-type allele designated asA), impact upon host susceptibility toCandidainfection. This systematic review and meta-analysis were performed to assess the association betweenMBL2codon 54 genotype and vulvovaginal candidiasis (VVC) or recurrent VVC (RVVC). Studies were searched in MEDLINE, SCOPUS, and ISI Web of Science until April 2013. Five studies including 704 women (386 cases and 318 controls) were part of the meta-analysis, and pooled ORs were calculated using the random effects model. For subjects with RVVC, ORs ofABversusAAand ofBBversusAAwere 4.84 (95% CI 2.10–11.15;Pfor heterogeneity=0.013;I2=68.6%) and 12.68 (95% CI 3.74–42.92;Pfor heterogeneity=0.932,I2=0.0%), respectively. For subjects with VVC, OR ofABversusAAwas 2.57 (95% CI 1.29–5.12;Pfor heterogeneity=0.897;I2=0.0%). This analysis indicates that heterozygosity for theMBL2alleleBincreases significantly the risk for both diseases, suggesting that MBL may influence the women’s innate immunity in response toCandida.

Lack of association between Mannose Binding Lectin-2 gene polymorphisms and periodontitis: A meta-analysis

Meta Gene ◽  
2020 ◽  
Vol 26 ◽  
pp. 100757
Author(s):  
Felipe Rodolfo Pereira da Silva ◽  
Alessandro Luiz Araújo Bentes Leal ◽  
Luigi Nibali ◽  
Jae Il Shin ◽  
Marcelo Diniz Carvalho ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Evaluation of Mannose Binding Lectin Gene Variants in Pediatric Influenza Virus-Related Critical Illness

2019 ◽  
Vol 10 ◽  
Author(s):  
Emily R. Levy ◽  
Wai-Ki Yip ◽  
Michael Super ◽  
Jill M. Ferdinands ◽  
Anushay J. Mistry ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Critical Illness ◽  
Mannose Binding Lectin ◽  
Gene Variants ◽  
Lectin Gene ◽  
Mannose Binding ◽  
Binding Lectin
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