Virulence factor genotyping of Helicobacter pylori isolated from Costa Rican dyspeptic patients

2019 ◽  
Vol 128 ◽  
pp. 276-280 ◽  
Author(s):  
Silvia Molina-Castro ◽  
Jerson Garita-Cambronero ◽  
Wendy Malespín-Bendaña ◽  
Clas Une ◽  
Vanessa Ramírez
Keyword(s):  
Helicobacter Pylori ◽  
Virulence Factor ◽  
Costa Rican

Inhibition of low-density lipoprotein uptake by Helicobacter pylori virulence factor CagA

2021 ◽  
Vol 556 ◽  
pp. 192-198
Author(s):  
Ryo Ninomiya ◽  
Shuichi Kubo ◽  
Takehiro Baba ◽  
Tooru Kajiwara ◽  
Akinori Tokunaga ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Virulence Factor ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Uptake

scholarly journals Molecular Characterization of a Flagellar Export Locus of Helicobacter pylori

1999 ◽  
Vol 67 (5) ◽  
pp. 2060-2070 ◽  
Author(s):  
Steffen Porwollik ◽  
Brian Noonan ◽  
Paul W. O’Toole
Keyword(s):  
Helicobacter Pylori ◽  
Virulence Factor ◽  
Housekeeping Genes ◽  
Reading Frame ◽  
Reverse Transcription Pcr ◽  
Mutant Strains ◽  
H Pylori ◽  
Export Protein ◽  
Successful Colonization

ABSTRACT Motility of Helicobacter species has been shown to be essential for successful colonization of the host. We have investigated the organization of a flagellar export locus in Helicobacter pylori. A 7-kb fragment of the H. pylori CCUG 17874 genome was cloned and sequenced, revealing an operon comprising an open reading frame of unknown function (ORF03), essential housekeeping genes (ileS and murB), flagellar export genes (fliI and fliQ), and a homolog to a gene implicated in virulence factor transport in other pathogens (virB11). A promoter for this operon, showing similarity to the Escherichia coli ς70 consensus, was identified by primer extension. Cotranscription of the genes in the operon was demonstrated by reverse transcription-PCR, and transcription of virB11, fliI, fliQ, andmurB was detected in human or mouse biopsies obtained from infected hosts. The genetic organization of this locus was conserved in a panel of H. pylori clinical isolates. EngineeredfliI and fliQ mutant strains were completely aflagellate and nonmotile, whereas a virB11 mutant still produced flagella. The fliI and fliQ mutant strains produced reduced levels of flagellin and the hook protein FlgE. Production of OMP4, a member of the outer membrane protein family identified in H. pylori 26695, was reduced in both thevirB11 mutant and the fliI mutant, suggesting related functions of the virulence factor export protein (VirB11) and the flagellar export component (FliI).

scholarly journals γ-Glutamyltransferase Is a Helicobacter pylori Virulence Factor but Is Not Essential for Colonization

2001 ◽  
Vol 69 (6) ◽  
pp. 4168-4173 ◽  
Author(s):  
K. J. McGovern ◽  
T. G. Blanchard ◽  
J. A. Gutierrez ◽  
S. J. Czinn ◽  
S. Krakowka ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Virulence Factor ◽  
Bacterial Load ◽  
H Pylori ◽  
Glutamyl Transpeptidase ◽  
Isogenic Strains

ABSTRACT The contribution of glutamyl transpeptidase (GGT) (γ-glutamyltransferase [EC 2. 3. 2. 2]) to Helicobacter pylori virulence was investigated in piglets and mice using GGT-deficient isogenic strains. All animals became colonized. However, the bacterial load was significantly lower for mutant bacteria than for parent strains. These results suggest that GGT activity provides an advantage to H. pylori in colonization.

Helicobacter pylori Virulence Factor Genotyping

2021 ◽  
pp. 93-106
Author(s):  
Rebecca FitzGerald ◽  
Chavi Sinha ◽  
Abbas Yadegar ◽  
Sinéad M. Smith
Keyword(s):  
Helicobacter Pylori ◽  
Virulence Factor

Helicobacter pylori in a costa rican dyspeptic patient population

1994 ◽  
Vol 13 (3) ◽  
pp. 253-257 ◽  
Author(s):  
B. Morera-Brenes ◽  
R. Sierra ◽  
R. Barrantes ◽  
J. Jonasson ◽  
C. E. Nord
Keyword(s):  
Helicobacter Pylori ◽  
Patient Population ◽  
Costa Rican ◽  
Dyspeptic Patient

scholarly journals Helicobacter pylori patient isolates from South Africa and Nigeria differ in virulence factor pathogenicity profile and associated gastric disease outcome

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Pia Palamides ◽  
Tolulope Jolaiya ◽  
Ayodeji Idowu ◽  
Eva Loell ◽  
Charles Onyekwere ◽  
...  
Keyword(s):  
South Africa ◽  
Helicobacter Pylori ◽  
Virulence Factor ◽  
Disease Outcome ◽  
Gastric Disease
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