Isolation and characterization of a broad-spectrum phage of multiple drug resistant Salmonella and its therapeutic utility in mice

2019 ◽  
Vol 126 ◽  
pp. 193-198 ◽  
Author(s):  
Fang Tang ◽  
Peng Zhang ◽  
Qingmei Zhang ◽  
Feng Xue ◽  
Jianluan Ren ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Isolation And Characterization ◽  
Multiple Drug Resistant ◽  
Therapeutic Utility

scholarly journals Isolation and Characterization of Multiple Drug Resistant Human Enteric Pathogens from Sewage Water of Delhi

2021 ◽  
Vol 20 (2) ◽  
Author(s):  
Rudrangshu Chatterjee ◽  
Dushyant Singh ◽  
Swati Tripathi ◽  
Abhishek Chauhan ◽  
M.L Aggarwal ◽  
...  
Keyword(s):  
Sewage Water ◽  
Enteric Pathogens ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Isolation And Characterization ◽  
Multiple Drug Resistant

Characterization of Two Clinical, Multiple-Drug-Resistant Isolates of Enterobacter cloacae

Chemotherapy ◽  
1984 ◽  
Vol 30 (5) ◽  
pp. 308-321 ◽  
Author(s):  
Walter H. Traub ◽  
Rolf Hüberle ◽  
Dierk Bauer
Keyword(s):  
Enterobacter Cloacae ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Multiple Drug Resistant

scholarly journals Isolation and Characterization of VceC Gain-of-Function Mutants That Can Function with the AcrAB Multiple-Drug-Resistant Efflux Pump of Escherichia coli

2006 ◽  
Vol 188 (11) ◽  
pp. 3757-3762 ◽  
Author(s):  
Govindsamy Vediyappan ◽  
Tatyana Borisova ◽  
Joe A. Fralick
Keyword(s):  
Escherichia Coli ◽  
Outer Membrane ◽  
Efflux Pump ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Membrane Component ◽  
Gain Of Function ◽  
Isolation And Characterization ◽  
Multiple Drug Resistant ◽  
Major Facilitator

ABSTRACT VceC is the outer membrane component of the major facilitator (MF) VceAB-VceC multiple-drug-resistant (MDR) efflux pump of Vibrio cholerae. TolC is the outer membrane component of the resistance-nodulation-division AcrAB-TolC efflux pump of Escherichia coli. Although these proteins share little amino acid sequence identity, their crystal structures can be readily superimposed upon one another. In this study, we have asked if TolC and VceC are interchangeable for the functioning of the AcrAB and VceAB pumps. We have found that TolC can replace VceC to form a functional VceAB-TolC MDR pump, but VceC cannot replace TolC to form a functional AcrAB-VceC pump. However, we have been able to isolate gain-of-function (gof) VceC mutants which can functionally interface with AcrAB. These mutations map to four different amino acids located at the periplasmic tip of VceC. Chemical cross-linkage experiments indicate that both wild-type and gof mutant VceC can physically interact with the AcrAB complex, suggesting that these gof mutations are not affecting the recruitment of VceC to the AcrAB complex but rather its ability to functionally interface with the AcrAB pump.

Characterization of a Nosocomially Significant, Multiple Drug-Resistant Strain of Serratia marcescens

Chemotherapy ◽  
1976 ◽  
Vol 22 (5) ◽  
pp. 297-312 ◽  
Author(s):  
Walter H. Traub ◽  
Ingrid Kleber ◽  
Alfred Pühler ◽  
Hans-Joachim Burkardt
Keyword(s):  
Resistant Strain ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Multiple Drug Resistant
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